FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153754546> ?p ?o ?g. }

• W2153754546 endingPage "818" @default.
• W2153754546 startingPage "812" @default.
• W2153754546 abstract "<h3>Objective</h3> <i>Helicobacter pylori</i> infection and overexpression of cyclo-oxygenase-2 (COX-2) are associated with gastric cancer and its precursors. To evaluate the effect of a selective COX-2 inhibitor alone and combined with <i>H pylori</i> eradication on the evolution of precancerous gastric lesions, a randomised, placebo-controlled trial was conducted in Linqu County, Shandong Province, China. <h3>Methods</h3> A total of 1024 participants aged 35–64 years with <i>H pylori</i> infection and advanced gastric lesions were randomly assigned in a factorial design to two interventions or placebo: anti-<i>H pylori</i> treatment for 7 days, and a COX-2 inhibitor (celecoxib) for 24 months. The effects of the interventions were evaluated by the regression or progression of advanced gastric lesions. <h3>Results</h3> Of the 1024 participants who received anti-<i>H pylori</i> treatment or placebo, 919 completed a subsequent 24-month treatment with celecoxib or placebo. The <i>H pylori</i> eradication rate by per-protocol analysis was 78.2%. Compared with placebo, the proportions of regression of gastric lesions significantly increased in the celecoxib treatment (52.8% vs 41.2%) and anti-<i>H pylori</i> treatment (59.3% vs 41.2%) group, and OR by per-protocol analysis was 1.72 (95% CI 1.07 to 2.76) for celecoxib and 2.19 (95% CI 1.32 to 3.64) for <i>H pylori</i> eradication. No statistically significant effect was found for <i>H pylori</i> eradication followed by celecoxib on the regression of advanced gastric lesions (OR 1.48, 95% CI 0.91 to 2.40). <h3>Conclusion</h3> This population-based intervention trial revealed that celecoxib treatment or <i>H pylori</i> eradication alone had beneficial effects on the regression of advanced gastric lesions. No favourable effects were seen for <i>H pylori</i> eradication followed by celecoxib treatment. <h3>Trial registration</h3> HARECCTR0500053 in accordance with WHO ICTRP requirements." @default.
• W2153754546 created "2016-06-24" @default.
• W2153754546 creator A5015798048 @default.
• W2153754546 creator A5018544690 @default.
• W2153754546 creator A5023986637 @default.
• W2153754546 creator A5035804461 @default.
• W2153754546 creator A5042015617 @default.
• W2153754546 creator A5042643943 @default.
• W2153754546 creator A5052474448 @default.
• W2153754546 creator A5059392900 @default.
• W2153754546 creator A5068252474 @default.
• W2153754546 creator A5070450933 @default.
• W2153754546 creator A5071057751 @default.
• W2153754546 creator A5073498218 @default.
• W2153754546 creator A5076594495 @default.
• W2153754546 creator A5084008211 @default.
• W2153754546 date "2011-09-13" @default.
• W2153754546 modified "2023-10-18" @default.
• W2153754546 title "Effects of selective COX-2 inhibitor and<i>Helicobacter pylori</i>eradication on precancerous gastric lesions" @default.
• W2153754546 cites W13136302 @default.
• W2153754546 cites W1786623082 @default.
• W2153754546 cites W1830830895 @default.
• W2153754546 cites W1975604533 @default.
• W2153754546 cites W1977811669 @default.
• W2153754546 cites W1979451045 @default.
• W2153754546 cites W1984265481 @default.
• W2153754546 cites W1997447221 @default.
• W2153754546 cites W1999390822 @default.
• W2153754546 cites W2001127864 @default.
• W2153754546 cites W2005143903 @default.
• W2153754546 cites W2017478434 @default.
• W2153754546 cites W2020830322 @default.
• W2153754546 cites W2023292042 @default.
• W2153754546 cites W2037980392 @default.
• W2153754546 cites W2040604645 @default.
• W2153754546 cites W2082580119 @default.
• W2153754546 cites W2082764531 @default.
• W2153754546 cites W2092120209 @default.
• W2153754546 cites W2104406460 @default.
• W2153754546 cites W2106787323 @default.
• W2153754546 cites W2116013694 @default.
• W2153754546 cites W2123393009 @default.
• W2153754546 cites W2129783761 @default.
• W2153754546 cites W2134234269 @default.
• W2153754546 cites W2142278204 @default.
• W2153754546 cites W2145653414 @default.
• W2153754546 cites W2146602272 @default.
• W2153754546 cites W2146686201 @default.
• W2153754546 cites W2154924098 @default.
• W2153754546 cites W2160504871 @default.
• W2153754546 cites W2160738204 @default.
• W2153754546 cites W2167250718 @default.
• W2153754546 cites W2171165592 @default.
• W2153754546 cites W2182856073 @default.
• W2153754546 cites W2406089649 @default.
• W2153754546 cites W2531077334 @default.
• W2153754546 cites W2948387191 @default.
• W2153754546 doi "https://doi.org/10.1136/gutjnl-2011-300154" @default.
• W2153754546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21917649" @default.
• W2153754546 hasPublicationYear "2011" @default.
• W2153754546 type Work @default.
• W2153754546 sameAs 2153754546 @default.
• W2153754546 citedByCount "126" @default.
• W2153754546 countsByYear W21537545462012 @default.
• W2153754546 countsByYear W21537545462013 @default.
• W2153754546 countsByYear W21537545462014 @default.
• W2153754546 countsByYear W21537545462015 @default.
• W2153754546 countsByYear W21537545462016 @default.
• W2153754546 countsByYear W21537545462017 @default.
• W2153754546 countsByYear W21537545462018 @default.
• W2153754546 countsByYear W21537545462019 @default.
• W2153754546 countsByYear W21537545462020 @default.
• W2153754546 countsByYear W21537545462021 @default.
• W2153754546 countsByYear W21537545462022 @default.
• W2153754546 countsByYear W21537545462023 @default.
• W2153754546 crossrefType "journal-article" @default.
• W2153754546 hasAuthorship W2153754546A5015798048 @default.
• W2153754546 hasAuthorship W2153754546A5018544690 @default.
• W2153754546 hasAuthorship W2153754546A5023986637 @default.
• W2153754546 hasAuthorship W2153754546A5035804461 @default.
• W2153754546 hasAuthorship W2153754546A5042015617 @default.
• W2153754546 hasAuthorship W2153754546A5042643943 @default.
• W2153754546 hasAuthorship W2153754546A5052474448 @default.
• W2153754546 hasAuthorship W2153754546A5059392900 @default.
• W2153754546 hasAuthorship W2153754546A5068252474 @default.
• W2153754546 hasAuthorship W2153754546A5070450933 @default.
• W2153754546 hasAuthorship W2153754546A5071057751 @default.
• W2153754546 hasAuthorship W2153754546A5073498218 @default.
• W2153754546 hasAuthorship W2153754546A5076594495 @default.
• W2153754546 hasAuthorship W2153754546A5084008211 @default.
• W2153754546 hasConcept C121608353 @default.
• W2153754546 hasConcept C126322002 @default.
• W2153754546 hasConcept C142724271 @default.
• W2153754546 hasConcept C204787440 @default.
• W2153754546 hasConcept C27081682 @default.
• W2153754546 hasConcept C2776409635 @default.
• W2153754546 hasConcept C2776467144 @default.
• W2153754546 hasConcept C2777498785 @default.

• next