FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153757400> ?p ?o ?g. }

• W2153757400 abstract "Objective: To investigate the impact of intravenous immunoglobulins (IVIg) on T cell (TC) activation and differentiation in TC-receptor (TCR) restricted TC in chronic inflammatory demyelinating polyneuropathy (CIDP).Background: CIDP is an acquired chronic autoimmune disease of the peripheral nervous system, which can be successfully treated with IVIg. Many efforts have been made to elucidate IVIg’s therapeutical mechanisms. Although T-cells mediate the link between humoral und cellular immunity, profound data on IVIg actions on TC in CIDP remain sparse.Design/Methods: PBL from n=30 patients with CIDP were analyzed longitudinally by FACS-Immunophenotyping, CDR3-Spectratyping and Cytokine-ELISA after initiation and during maintenance IVIg treatment.Results: We found a recovery of individually expanded T-cell-receptor repertoire after IVIg-treatment initiation. Providing a deeper insight into immunomodulation our data indicate that these suppressive actions are accompanied by a shift from a pro-inflammatory TH1 to an anti-inflammatory TH2 cytokine milieu (FACS, ELISA). We here provide evidence, that a mature (CD45RO+CD45RA-CD62lowCD28low) and highly activated (LFA-1highVLA-4high) TH1 cell (CCR4highCCR5low) subpopulation, which carries a single patient-specific TCR-vβ chain, is suppressed during IVIg-therapy. As correlated with a significant increase in serum TH2 index cytokine IL-4 levels 2 weeks after IVIg-initiation, this might contribute to therapeutic effects regarding anti- inflammation and clinical restitution in CIDP. In addition, deviations in serum cytokine milieu refer also to TH1 and TH17 index cytokines INF-γ and IL-17.Conclusions: As IL-4 serum levels are found to be markedly high only in short intervals (2 weeks) after IVIg-administration, correlating with patients’ clinical improvement, and then decrease until the next, therapeutical benefits might be due to a pulsatile TH2 induction. This TH2 shift might lead to a short-term restitution of serum milieu and cellular immunehomeostasis, that, in contrast, cannot overcome pathological autoimmunity, necessitating maintenance therapy, as seen in clinical practice. To our knowledge, this TC subset characterization is the first to contribute to functional relevance of TCR repertoire recovery by IVIg. Disclosure: Dr. Russwurm has nothing to disclose. Dr. Putz has nothing to disclose. Dr. Hoft has nothing to disclose. Dr. Schlegel has nothing to disclose. Dr. Happel has nothing to disclose. Dr Eienbroker has received personal compensation for activities with Biogen Idec, Novartis, and Temmler Pharma. Dr Seipelt has received personal compensation for activities with Biogen Idec, Genzyme Corp. and Novartis. Dr. Tackenberg has received personal compensation for activities with Bayer Pharmaceuticals Corp., Biogen Idec, Merck Serono, Novartis, and Teva Neuroscience. Dr. Tackenberg has received research support from Bayer Pharmaceuticals Corp., Biogen Idec, and Novartis." @default.
• W2153757400 created "2016-06-24" @default.
• W2153757400 creator A5007260575 @default.
• W2153757400 creator A5008484778 @default.
• W2153757400 creator A5012090226 @default.
• W2153757400 creator A5015918322 @default.
• W2153757400 creator A5022758228 @default.
• W2153757400 creator A5023701418 @default.
• W2153757400 creator A5055205557 @default.
• W2153757400 creator A5059328086 @default.
• W2153757400 date "2014-04-08" @default.
• W2153757400 modified "2023-09-29" @default.
• W2153757400 title "Pulsatile TH2 Shift Of Recovering TCR-Vβ Expanded T-Helper Effector Cells After Initiation Of IVIG Treatment in CIDP (P1.074)" @default.
• W2153757400 hasPublicationYear "2014" @default.
• W2153757400 type Work @default.
• W2153757400 sameAs 2153757400 @default.
• W2153757400 citedByCount "0" @default.
• W2153757400 crossrefType "journal-article" @default.
• W2153757400 hasAuthorship W2153757400A5007260575 @default.
• W2153757400 hasAuthorship W2153757400A5008484778 @default.
• W2153757400 hasAuthorship W2153757400A5012090226 @default.
• W2153757400 hasAuthorship W2153757400A5015918322 @default.
• W2153757400 hasAuthorship W2153757400A5022758228 @default.
• W2153757400 hasAuthorship W2153757400A5023701418 @default.
• W2153757400 hasAuthorship W2153757400A5055205557 @default.
• W2153757400 hasAuthorship W2153757400A5059328086 @default.
• W2153757400 hasConcept C154317977 @default.
• W2153757400 hasConcept C159654299 @default.
• W2153757400 hasConcept C202751555 @default.
• W2153757400 hasConcept C203014093 @default.
• W2153757400 hasConcept C2776090121 @default.
• W2153757400 hasConcept C2778690821 @default.
• W2153757400 hasConcept C2779234475 @default.
• W2153757400 hasConcept C2779867792 @default.
• W2153757400 hasConcept C39347974 @default.
• W2153757400 hasConcept C55493867 @default.
• W2153757400 hasConcept C71924100 @default.
• W2153757400 hasConcept C86803240 @default.
• W2153757400 hasConcept C8891405 @default.
• W2153757400 hasConceptScore W2153757400C154317977 @default.
• W2153757400 hasConceptScore W2153757400C159654299 @default.
• W2153757400 hasConceptScore W2153757400C202751555 @default.
• W2153757400 hasConceptScore W2153757400C203014093 @default.
• W2153757400 hasConceptScore W2153757400C2776090121 @default.
• W2153757400 hasConceptScore W2153757400C2778690821 @default.
• W2153757400 hasConceptScore W2153757400C2779234475 @default.
• W2153757400 hasConceptScore W2153757400C2779867792 @default.
• W2153757400 hasConceptScore W2153757400C39347974 @default.
• W2153757400 hasConceptScore W2153757400C55493867 @default.
• W2153757400 hasConceptScore W2153757400C71924100 @default.
• W2153757400 hasConceptScore W2153757400C86803240 @default.
• W2153757400 hasConceptScore W2153757400C8891405 @default.
• W2153757400 hasLocation W21537574001 @default.
• W2153757400 hasOpenAccess W2153757400 @default.
• W2153757400 hasPrimaryLocation W21537574001 @default.
• W2153757400 hasRelatedWork W1500359438 @default.
• W2153757400 hasRelatedWork W1584496237 @default.
• W2153757400 hasRelatedWork W1979492332 @default.
• W2153757400 hasRelatedWork W1991863290 @default.
• W2153757400 hasRelatedWork W2052739550 @default.
• W2153757400 hasRelatedWork W2074653986 @default.
• W2153757400 hasRelatedWork W2222638418 @default.
• W2153757400 hasRelatedWork W2260666658 @default.
• W2153757400 hasRelatedWork W2329347983 @default.
• W2153757400 hasRelatedWork W2539063465 @default.
• W2153757400 hasRelatedWork W2553513103 @default.
• W2153757400 hasRelatedWork W2564362989 @default.
• W2153757400 hasRelatedWork W2602697026 @default.
• W2153757400 hasRelatedWork W2786233742 @default.
• W2153757400 hasRelatedWork W2906090323 @default.
• W2153757400 hasRelatedWork W2953775066 @default.
• W2153757400 hasRelatedWork W2969786563 @default.
• W2153757400 hasRelatedWork W3006665844 @default.
• W2153757400 hasRelatedWork W3090878309 @default.
• W2153757400 hasRelatedWork W3163080462 @default.
• W2153757400 hasVolume "82" @default.
• W2153757400 isParatext "false" @default.
• W2153757400 isRetracted "false" @default.
• W2153757400 magId "2153757400" @default.
• W2153757400 workType "article" @default.