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- W2153811538 abstract "Abstract Enhanced expression levels of integrin αvβ6 have been linked to more aggressive invasive carcinoma cell behavior and poorer clinical prognosis. However, how αvβ6 determines invasion and the dynamics of integrin αvβ6 regulation in tumor cells are poorly understood. We have identified the 35-kDa HS1-associated protein X-1 (HAX-1) protein as a novel binding partner of the β6 cytoplasmic tail using a yeast two-hybrid screen. We show that αvβ6-dependent migration is blocked following small interfering RNA (siRNA)–mediated depletion of HAX-1 in oral squamous cell carcinoma cell lines. Using both siRNA and membrane-permeable peptides, we show that αvβ6-dependent migration and invasion require HAX-1 to bind directly to β6 and thereby regulate clathrin-mediated endocytosis of αvβ6 integrins. Progression of oral cancer is associated with enhanced expression of αvβ6 and HAX-1 proteins in patient tissue. This report establishes that integrin endocytosis is required for αvβ6-dependent carcinoma cell motility and invasion and suggests that this process is an important mechanism in cancer progression. [Cancer Res 2007;67(11):5275–84]" @default.
- W2153811538 created "2016-06-24" @default.
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- W2153811538 date "2007-06-01" @default.
- W2153811538 modified "2023-09-27" @default.
- W2153811538 title "HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6" @default.
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- W2153811538 doi "https://doi.org/10.1158/0008-5472.can-07-0318" @default.
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