FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153831087> ?p ?o ?g. }

• W2153831087 endingPage "215" @default.
• W2153831087 startingPage "199" @default.
• W2153831087 abstract "Communication usually applies feedback loop–based filters and amplifiers to ensure undistorted delivery of messages. Such an amplifier acts during Drosophila melanogaster midoogenesis, when oskar messenger ribonucleic acid (mRNA) anchoring depends on its own locally translated protein product. We find that the motor regulator Klar β mediates a gain-control process that prevents saturation-based distortions in this positive feedback loop. We demonstrate that, like oskar mRNA, Klar β localizes to the posterior pole of oocytes in a kinesin-1–dependent manner. By live imaging and semiquantitative fluorescent in situ hybridization, we show that Klar β restrains oskar ribonucleoprotein motility and decreases the posterior-ward translocation of oskar mRNA, thereby adapting the rate of oskar delivery to the output of the anchoring machinery. This negative regulatory effect of Klar is particularly important for overriding temperature-induced changes in motility. We conclude that by preventing defects in oskar anchoring, this mechanism contributes to the developmental robustness of a poikilothermic organism living in a variable temperature environment." @default.
• W2153831087 created "2016-06-24" @default.
• W2153831087 creator A5002402095 @default.
• W2153831087 creator A5006681896 @default.
• W2153831087 creator A5032410734 @default.
• W2153831087 creator A5060666860 @default.
• W2153831087 creator A5063125822 @default.
• W2153831087 creator A5076973138 @default.
• W2153831087 date "2014-07-21" @default.
• W2153831087 modified "2023-10-03" @default.
• W2153831087 title "Klar ensures thermal robustness of <i>oskar</i> localization by restraining RNP motility" @default.
• W2153831087 cites W1559389849 @default.
• W2153831087 cites W1970161246 @default.
• W2153831087 cites W1979075281 @default.
• W2153831087 cites W1980793772 @default.
• W2153831087 cites W1985687970 @default.
• W2153831087 cites W1997375431 @default.
• W2153831087 cites W1997572381 @default.
• W2153831087 cites W1999691874 @default.
• W2153831087 cites W2000907799 @default.
• W2153831087 cites W2001044160 @default.
• W2153831087 cites W2002256260 @default.
• W2153831087 cites W2005326389 @default.
• W2153831087 cites W2009747268 @default.
• W2153831087 cites W2014725103 @default.
• W2153831087 cites W2015229379 @default.
• W2153831087 cites W2022989270 @default.
• W2153831087 cites W2025439653 @default.
• W2153831087 cites W2028532937 @default.
• W2153831087 cites W2035424802 @default.
• W2153831087 cites W2038443908 @default.
• W2153831087 cites W2046720103 @default.
• W2153831087 cites W2047040065 @default.
• W2153831087 cites W2049517402 @default.
• W2153831087 cites W2063522739 @default.
• W2153831087 cites W2066885869 @default.
• W2153831087 cites W2069939812 @default.
• W2153831087 cites W2081580757 @default.
• W2153831087 cites W2093291036 @default.
• W2153831087 cites W2097179914 @default.
• W2153831087 cites W2098889694 @default.
• W2153831087 cites W2101764488 @default.
• W2153831087 cites W2104650708 @default.
• W2153831087 cites W2104753410 @default.
• W2153831087 cites W2105513224 @default.
• W2153831087 cites W2107291116 @default.
• W2153831087 cites W2110170651 @default.
• W2153831087 cites W2114733852 @default.
• W2153831087 cites W2117595639 @default.
• W2153831087 cites W2120010703 @default.
• W2153831087 cites W2123008200 @default.
• W2153831087 cites W2128427159 @default.
• W2153831087 cites W2139486492 @default.
• W2153831087 cites W2139865462 @default.
• W2153831087 cites W2142606014 @default.
• W2153831087 cites W2153681451 @default.
• W2153831087 cites W2160708064 @default.
• W2153831087 cites W2181461782 @default.
• W2153831087 cites W2395762000 @default.
• W2153831087 cites W4211017114 @default.
• W2153831087 doi "https://doi.org/10.1083/jcb.201310010" @default.
• W2153831087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4107779" @default.
• W2153831087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25049271" @default.
• W2153831087 hasPublicationYear "2014" @default.
• W2153831087 type Work @default.
• W2153831087 sameAs 2153831087 @default.
• W2153831087 citedByCount "26" @default.
• W2153831087 countsByYear W21538310872015 @default.
• W2153831087 countsByYear W21538310872016 @default.
• W2153831087 countsByYear W21538310872017 @default.
• W2153831087 countsByYear W21538310872018 @default.
• W2153831087 countsByYear W21538310872019 @default.
• W2153831087 countsByYear W21538310872021 @default.
• W2153831087 countsByYear W21538310872022 @default.
• W2153831087 countsByYear W21538310872023 @default.
• W2153831087 crossrefType "journal-article" @default.
• W2153831087 hasAuthorship W2153831087A5002402095 @default.
• W2153831087 hasAuthorship W2153831087A5006681896 @default.
• W2153831087 hasAuthorship W2153831087A5032410734 @default.
• W2153831087 hasAuthorship W2153831087A5060666860 @default.
• W2153831087 hasAuthorship W2153831087A5063125822 @default.
• W2153831087 hasAuthorship W2153831087A5076973138 @default.
• W2153831087 hasBestOaLocation W21538310871 @default.
• W2153831087 hasConcept C104317684 @default.
• W2153831087 hasConcept C174353785 @default.
• W2153831087 hasConcept C2780104201 @default.
• W2153831087 hasConcept C54355233 @default.
• W2153831087 hasConcept C58207958 @default.
• W2153831087 hasConcept C63479239 @default.
• W2153831087 hasConcept C6929976 @default.
• W2153831087 hasConcept C86803240 @default.
• W2153831087 hasConcept C95444343 @default.
• W2153831087 hasConceptScore W2153831087C104317684 @default.
• W2153831087 hasConceptScore W2153831087C174353785 @default.
• W2153831087 hasConceptScore W2153831087C2780104201 @default.
• W2153831087 hasConceptScore W2153831087C54355233 @default.
• W2153831087 hasConceptScore W2153831087C58207958 @default.
• W2153831087 hasConceptScore W2153831087C63479239 @default.

• next