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• W2153846543 startingPage "2477" @default.
• W2153846543 abstract "Macrophages (MΦs) colonize tissues during inflammation in two distinct ways: recruitment of monocyte precursors and proliferation of resident cells. We recently revealed a major role for IL-4 in the proliferative expansion of resident MΦs during a Th2-biased tissue nematode infection. We now show that proliferation of MΦs during intestinal as well as tissue nematode infection is restricted to sites of IL-4 production and requires MΦ-intrinsic IL-4R signaling. However, both IL-4Rα–dependent and –independent mechanisms contributed to MΦ proliferation during nematode infections. IL-4R–independent proliferation was controlled by a rise in local CSF-1 levels, but IL-4Rα expression conferred a competitive advantage with higher and more sustained proliferation and increased accumulation of IL-4Rα+ compared with IL-4Rα− cells. Mechanistically, this occurred by conversion of IL-4Rα+ MΦs from a CSF-1–dependent to –independent program of proliferation. Thus, IL-4 increases the relative density of tissue MΦs by overcoming the constraints mediated by the availability of CSF-1. Finally, although both elevated CSF1R and IL-4Rα signaling triggered proliferation above homeostatic levels, only CSF-1 led to the recruitment of monocytes and neutrophils. Thus, the IL-4 pathway of proliferation may have developed as an alternative to CSF-1 to increase resident MΦ numbers without coincident monocyte recruitment." @default.
• W2153846543 created "2016-06-24" @default.
• W2153846543 creator A5003549501 @default.
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• W2153846543 date "2013-10-07" @default.
• W2153846543 modified "2023-10-11" @default.
• W2153846543 title "IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1" @default.
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• W2153846543 doi "https://doi.org/10.1084/jem.20121999" @default.
• W2153846543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3804948" @default.
• W2153846543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24101381" @default.
• W2153846543 hasPublicationYear "2013" @default.
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