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- W2153864165 abstract "In a search for new antihistamines, a series of oximino esters of 2-, 3-, and 4-benzoylpyridine oxime and 2-benzoylthiophene oxime was prepared. The respective ketones were oximinated in pyridine with hydroxylamine hydrochloride. The esterification was conducted in benzene with equimolar quantities of acetyl chloride, oxime, and a basic reagent. Twelve new oximino esters were synthesized and evaluated for their antihistaminic activity. All synthesized compounds exhibited antihistaminic activity with almost no anticholinergic action. The propionyl analogs showed the most significant antihistaminic effectiveness." @default.
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- W2153864165 date "1967-10-01" @default.
- W2153864165 modified "2023-09-26" @default.
- W2153864165 title "Synthesis of ketoximino esters as antihistaminics" @default.
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- W2153864165 doi "https://doi.org/10.1002/jps.2600561033" @default.
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