FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153886170> ?p ?o ?g. }

• W2153886170 endingPage "407" @default.
• W2153886170 startingPage "397" @default.
• W2153886170 abstract "ABSTRACT Bacterial pathogens use virulence strategies to invade epithelial barriers, but active processes of epithelial cells may also contribute to the endocytosis of microbial particles. To focus on the latter, we studied the uptake of fixed and fluorescently labeled bacterial particles in intestinal and bronchoepithelial cell cultures and found it to be enhanced in Caco-2BBe and NCI-H292 cells after treatment with tumor necrosis factor alpha and an agonist antibody against the lymphotoxin beta receptor. Confocal fluorescence microscopy, flow cytometry, and transmission electron microscopy revealed that Staphylococcus aureus and Yersinia enterocolitica were readily endocytosed, although there was scant uptake of Shigella sonnei , Salmonella enterica serovar Typhimurium, and Klebsiella pneumoniae particles. Endocytosed Staphylococcus was often associated with cytoplasmic claudin-4 vesicles; this was not found for Yersinia , suggesting that cytokine treatment upregulated two distinct endocytosis pathways. Interestingly, when Staphylococcus and Yersinia were coincubated with epithelial monolayers, the cells were unlikely to take up Yersinia unless they had also endocytosed large numbers of Staphylococcus particles, although the two bacteria were apparently processed in distinct compartments. Cytokine treatment induced an upregulation and redistribution of β1 integrin to the apical surface of NCI-H292 cells; consistent with this effect, treatment with anti-β1 integrin antibody blocked uptake of both Yersinia and Staphylococcus in NCI-H292 and Caco-2BBe cells. Our results suggest that capture of bacterial particles by mucosal epithelial cells is selective and that different endocytic mechanisms are enhanced by proinflammatory cytokines." @default.
• W2153886170 created "2016-06-24" @default.
• W2153886170 creator A5005174685 @default.
• W2153886170 creator A5010067099 @default.
• W2153886170 creator A5021583072 @default.
• W2153886170 creator A5037853215 @default.
• W2153886170 creator A5091129386 @default.
• W2153886170 date "2009-03-01" @default.
• W2153886170 modified "2023-09-27" @default.
• W2153886170 title "Bacterial Particle Endocytosis by Epithelial Cells Is Selective and Enhanced by Tumor Necrosis Factor Receptor Ligands" @default.
• W2153886170 cites W1486750235 @default.
• W2153886170 cites W1997103512 @default.
• W2153886170 cites W2006194008 @default.
• W2153886170 cites W2009160702 @default.
• W2153886170 cites W2034640788 @default.
• W2153886170 cites W2041791106 @default.
• W2153886170 cites W2049959662 @default.
• W2153886170 cites W2052384425 @default.
• W2153886170 cites W2055222262 @default.
• W2153886170 cites W2072380594 @default.
• W2153886170 cites W2073831807 @default.
• W2153886170 cites W2078519703 @default.
• W2153886170 cites W2078825274 @default.
• W2153886170 cites W2079830553 @default.
• W2153886170 cites W2088194700 @default.
• W2153886170 cites W2092310219 @default.
• W2153886170 cites W2093247535 @default.
• W2153886170 cites W2095076124 @default.
• W2153886170 cites W2099585656 @default.
• W2153886170 cites W2103598274 @default.
• W2153886170 cites W2106345771 @default.
• W2153886170 cites W2106962511 @default.
• W2153886170 cites W2119331847 @default.
• W2153886170 cites W2122039020 @default.
• W2153886170 cites W2126197220 @default.
• W2153886170 cites W2165996003 @default.
• W2153886170 cites W2167503339 @default.
• W2153886170 cites W2167933104 @default.
• W2153886170 doi "https://doi.org/10.1128/cvi.00210-08" @default.
• W2153886170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2650861" @default.
• W2153886170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19129472" @default.
• W2153886170 hasPublicationYear "2009" @default.
• W2153886170 type Work @default.
• W2153886170 sameAs 2153886170 @default.
• W2153886170 citedByCount "14" @default.
• W2153886170 countsByYear W21538861702012 @default.
• W2153886170 countsByYear W21538861702014 @default.
• W2153886170 countsByYear W21538861702015 @default.
• W2153886170 countsByYear W21538861702016 @default.
• W2153886170 countsByYear W21538861702018 @default.
• W2153886170 countsByYear W21538861702019 @default.
• W2153886170 countsByYear W21538861702020 @default.
• W2153886170 crossrefType "journal-article" @default.
• W2153886170 hasAuthorship W2153886170A5005174685 @default.
• W2153886170 hasAuthorship W2153886170A5010067099 @default.
• W2153886170 hasAuthorship W2153886170A5021583072 @default.
• W2153886170 hasAuthorship W2153886170A5037853215 @default.
• W2153886170 hasAuthorship W2153886170A5091129386 @default.
• W2153886170 hasBestOaLocation W21538861701 @default.
• W2153886170 hasConcept C104317684 @default.
• W2153886170 hasConcept C164027704 @default.
• W2153886170 hasConcept C170493617 @default.
• W2153886170 hasConcept C17991360 @default.
• W2153886170 hasConcept C203014093 @default.
• W2153886170 hasConcept C2776234502 @default.
• W2153886170 hasConcept C2776255393 @default.
• W2153886170 hasConcept C2776914184 @default.
• W2153886170 hasConcept C2777353990 @default.
• W2153886170 hasConcept C2779607309 @default.
• W2153886170 hasConcept C2781065037 @default.
• W2153886170 hasConcept C28005876 @default.
• W2153886170 hasConcept C523546767 @default.
• W2153886170 hasConcept C54355233 @default.
• W2153886170 hasConcept C55493867 @default.
• W2153886170 hasConcept C60987743 @default.
• W2153886170 hasConcept C86803240 @default.
• W2153886170 hasConcept C89423630 @default.
• W2153886170 hasConcept C95444343 @default.
• W2153886170 hasConceptScore W2153886170C104317684 @default.
• W2153886170 hasConceptScore W2153886170C164027704 @default.
• W2153886170 hasConceptScore W2153886170C170493617 @default.
• W2153886170 hasConceptScore W2153886170C17991360 @default.
• W2153886170 hasConceptScore W2153886170C203014093 @default.
• W2153886170 hasConceptScore W2153886170C2776234502 @default.
• W2153886170 hasConceptScore W2153886170C2776255393 @default.
• W2153886170 hasConceptScore W2153886170C2776914184 @default.
• W2153886170 hasConceptScore W2153886170C2777353990 @default.
• W2153886170 hasConceptScore W2153886170C2779607309 @default.
• W2153886170 hasConceptScore W2153886170C2781065037 @default.
• W2153886170 hasConceptScore W2153886170C28005876 @default.
• W2153886170 hasConceptScore W2153886170C523546767 @default.
• W2153886170 hasConceptScore W2153886170C54355233 @default.
• W2153886170 hasConceptScore W2153886170C55493867 @default.
• W2153886170 hasConceptScore W2153886170C60987743 @default.
• W2153886170 hasConceptScore W2153886170C86803240 @default.
• W2153886170 hasConceptScore W2153886170C89423630 @default.
• W2153886170 hasConceptScore W2153886170C95444343 @default.
• W2153886170 hasIssue "3" @default.

• next