Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153887456> ?p ?o ?g. }
- W2153887456 endingPage "661" @default.
- W2153887456 startingPage "652" @default.
- W2153887456 abstract "Abstract Hodgkin lymphoma is caused by a minority population of malignant Hodgkin and Reed–Sternberg (HRS) cells that recruit an abundance of inflammatory cells. The long-term survival of HRS cells among the vast majority of immune cells indicates that they have developed potent immune escape mechanisms. We report that the TNF receptor family member CD137 (TNFRSF9) is expressed on HRS cells, while normal B cells, from which HRS cells are most often derived, do not express CD137. In 48 of 53 cases of classical Hodgkin lymphoma, CD137 was detected on HRS cells. Ectopically expressed CD137 transferred by trogocytosis from HRS cells to neighboring HRS and antigen-presenting cells, which constitutively express the CD137 ligand (CD137L and TNFSF9), became associated with CD137L and the CD137–CD137L complex was internalized. Disappearance of CD137L from the surface of HRS and antigen-presenting cells led to reduced costimulation of T cells through CD137, reducing IFN-γ release and proliferation. Our results reveal a new regulatory mechanism for CD137L expression that mediates immune escape by HRS cells, and they identify CD137 as a candidate target for immunotherapy of Hodgkin lymphoma. Cancer Res; 73(2); 652–61. ©2012 AACR." @default.
- W2153887456 created "2016-06-24" @default.
- W2153887456 creator A5005355912 @default.
- W2153887456 creator A5008829054 @default.
- W2153887456 creator A5011237730 @default.
- W2153887456 creator A5026162732 @default.
- W2153887456 creator A5034564322 @default.
- W2153887456 creator A5045088174 @default.
- W2153887456 creator A5063159222 @default.
- W2153887456 creator A5076291129 @default.
- W2153887456 creator A5080640808 @default.
- W2153887456 creator A5088675202 @default.
- W2153887456 creator A5090517327 @default.
- W2153887456 date "2013-01-15" @default.
- W2153887456 modified "2023-10-15" @default.
- W2153887456 title "Expression of CD137 on Hodgkin and Reed–Sternberg Cells Inhibits T-cell Activation by Eliminating CD137 Ligand Expression" @default.
- W2153887456 cites W1483299903 @default.
- W2153887456 cites W1537714877 @default.
- W2153887456 cites W1830102914 @default.
- W2153887456 cites W1870078228 @default.
- W2153887456 cites W1968101362 @default.
- W2153887456 cites W1970866936 @default.
- W2153887456 cites W1976920637 @default.
- W2153887456 cites W1987866336 @default.
- W2153887456 cites W1998006783 @default.
- W2153887456 cites W1999194653 @default.
- W2153887456 cites W2013546754 @default.
- W2153887456 cites W2019665806 @default.
- W2153887456 cites W2027907558 @default.
- W2153887456 cites W2029857486 @default.
- W2153887456 cites W2037231270 @default.
- W2153887456 cites W2046972425 @default.
- W2153887456 cites W2047526240 @default.
- W2153887456 cites W2049794122 @default.
- W2153887456 cites W2051830227 @default.
- W2153887456 cites W2052796707 @default.
- W2153887456 cites W2066015053 @default.
- W2153887456 cites W2067271905 @default.
- W2153887456 cites W2071065868 @default.
- W2153887456 cites W2075061087 @default.
- W2153887456 cites W2075411691 @default.
- W2153887456 cites W2084224223 @default.
- W2153887456 cites W2088218927 @default.
- W2153887456 cites W2092317746 @default.
- W2153887456 cites W2092972513 @default.
- W2153887456 cites W2094798767 @default.
- W2153887456 cites W2097765486 @default.
- W2153887456 cites W2108292466 @default.
- W2153887456 cites W2111842974 @default.
- W2153887456 cites W2112879111 @default.
- W2153887456 cites W2119605929 @default.
- W2153887456 cites W2158216603 @default.
- W2153887456 cites W2166024764 @default.
- W2153887456 cites W2170758122 @default.
- W2153887456 doi "https://doi.org/10.1158/0008-5472.can-12-3849" @default.
- W2153887456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23204227" @default.
- W2153887456 hasPublicationYear "2013" @default.
- W2153887456 type Work @default.
- W2153887456 sameAs 2153887456 @default.
- W2153887456 citedByCount "58" @default.
- W2153887456 countsByYear W21538874562013 @default.
- W2153887456 countsByYear W21538874562014 @default.
- W2153887456 countsByYear W21538874562015 @default.
- W2153887456 countsByYear W21538874562016 @default.
- W2153887456 countsByYear W21538874562017 @default.
- W2153887456 countsByYear W21538874562018 @default.
- W2153887456 countsByYear W21538874562019 @default.
- W2153887456 countsByYear W21538874562020 @default.
- W2153887456 countsByYear W21538874562021 @default.
- W2153887456 countsByYear W21538874562022 @default.
- W2153887456 countsByYear W21538874562023 @default.
- W2153887456 crossrefType "journal-article" @default.
- W2153887456 hasAuthorship W2153887456A5005355912 @default.
- W2153887456 hasAuthorship W2153887456A5008829054 @default.
- W2153887456 hasAuthorship W2153887456A5011237730 @default.
- W2153887456 hasAuthorship W2153887456A5026162732 @default.
- W2153887456 hasAuthorship W2153887456A5034564322 @default.
- W2153887456 hasAuthorship W2153887456A5045088174 @default.
- W2153887456 hasAuthorship W2153887456A5063159222 @default.
- W2153887456 hasAuthorship W2153887456A5076291129 @default.
- W2153887456 hasAuthorship W2153887456A5080640808 @default.
- W2153887456 hasAuthorship W2153887456A5088675202 @default.
- W2153887456 hasAuthorship W2153887456A5090517327 @default.
- W2153887456 hasBestOaLocation W21538874561 @default.
- W2153887456 hasConcept C147483822 @default.
- W2153887456 hasConcept C153911025 @default.
- W2153887456 hasConcept C185592680 @default.
- W2153887456 hasConcept C203014093 @default.
- W2153887456 hasConcept C2777701055 @default.
- W2153887456 hasConcept C2779338263 @default.
- W2153887456 hasConcept C2779390272 @default.
- W2153887456 hasConcept C2780249625 @default.
- W2153887456 hasConcept C2908647359 @default.
- W2153887456 hasConcept C2992779791 @default.
- W2153887456 hasConcept C502942594 @default.
- W2153887456 hasConcept C71924100 @default.
- W2153887456 hasConcept C86803240 @default.
- W2153887456 hasConcept C8891405 @default.