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- W2153907975 abstract "The Notch gene of Drosophila encodes a large transmembrane protein involved in cell-cell interactions and cell fate decisions in the Drosophila embryo. We report here the isolation of cDNA clones encompassing the full-length coding sequence of Notch-1, a mouse homolog of Drosophila Notch. The predicted amino acid sequence of the Notch-1 protein retains all of the conserved amino acid motifs of Notch and the other vertebrate Notch homologs. The cDNA sequence predicts a 2531-amino-acid protein containing a signal peptide, 36 epidermal growth factor-like repeats, 3 Notch/lin-12 repeats, a transmembrane domain, and 6 cdc10/ankyrin repeats. The Notch-1 gene was localized to the proximal portion of mouse chromosome 2 by mapping with an interspecific backcross panel." @default.
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- W2153907975 date "1993-02-01" @default.
- W2153907975 modified "2023-10-15" @default.
- W2153907975 title "Cloning, Analysis, and Chromosomal Localization of Notch-1, a Mouse Homolog of Drosophila Notch" @default.
- W2153907975 doi "https://doi.org/10.1006/geno.1993.1055" @default.
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