FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153914897> ?p ?o ?g. }

• W2153914897 endingPage "9" @default.
• W2153914897 startingPage "433" @default.
• W2153914897 abstract "Human melanoma cells freshly isolated from 20 patients with primary and 73 patients with metastatic melanomas were analyzed by indirect immunofluorescence staining with monoclonal antibodies (MoAb) to class I (HLA-A, -B, and -C) and class II (HLA-DR and -DQ) antigens and to melanoma associated antigen (MAA). The latter included the GD3-MAA and the high molecular weight MAA. HLA class I antigens were present in 91 and 93% of primary and metastatic tumors, respectively. GD3-MAA was detected in 100% of primary and 80% of metastatic tumors. Whereas the high molecular weight MAA was expressed in 75% of tumors. Sixty % of primary and 50% of metastatic melanomas were stained by anti-HLA-DR MoAb, whereas 38 and 21% of cases, respectively, were stained by anti-HLA-DQ MoAb. Marked phenotypic heterogeneity was evident among primary and metastatic tumors, including different metastases from the same patient. Moreover, in vitro culture of melanoma cells isolated from metastases was associated with an increase from 50 to 75% of tumors stained by anti-HLA-DR MoAb but not of tumors positive for HLA class I antigens and MAA. In vitro incubation with partially purified or recombinant human gamma-interferon enhanced the expression of HLA-DR antigens on all short-term cultured melanoma cells tested but induced and/or augmented the expression of HLA-DQ antigens only in 5 of the 8 cases examined. The average increase in antigenic expression was higher for HLA-DQ than for HLA-DR antigens. Flow cytometric measurement of DNA content of melanoma cells treated with gamma-interferon revealed that the increase of HLA-DR and -DQ expression induced by gamma-interferon was independent from the cell cycle of the tumor cells." @default.
• W2153914897 created "2016-06-24" @default.
• W2153914897 creator A5007546821 @default.
• W2153914897 creator A5028028874 @default.
• W2153914897 creator A5028669896 @default.
• W2153914897 creator A5056175990 @default.
• W2153914897 creator A5062210857 @default.
• W2153914897 creator A5083523436 @default.
• W2153914897 date "1986-01-01" @default.
• W2153914897 modified "2023-09-23" @default.
• W2153914897 title "Classes I and II HLA and melanoma-associated antigen expression and modulation on melanoma cells isolated from primary and metastatic lesions." @default.
• W2153914897 cites W1549216397 @default.
• W2153914897 cites W1567654782 @default.
• W2153914897 cites W1589888021 @default.
• W2153914897 cites W1639127570 @default.
• W2153914897 cites W1927697103 @default.
• W2153914897 cites W1964203232 @default.
• W2153914897 cites W1966795694 @default.
• W2153914897 cites W1973028961 @default.
• W2153914897 cites W1975029709 @default.
• W2153914897 cites W1983734302 @default.
• W2153914897 cites W1998239567 @default.
• W2153914897 cites W2004489349 @default.
• W2153914897 cites W2015742067 @default.
• W2153914897 cites W2020183970 @default.
• W2153914897 cites W2037615462 @default.
• W2153914897 cites W2045844687 @default.
• W2153914897 cites W2045917505 @default.
• W2153914897 cites W2059683241 @default.
• W2153914897 cites W2065848252 @default.
• W2153914897 cites W2067615306 @default.
• W2153914897 cites W2068317899 @default.
• W2153914897 cites W2070283658 @default.
• W2153914897 cites W2074775744 @default.
• W2153914897 cites W2076092809 @default.
• W2153914897 cites W2081796665 @default.
• W2153914897 cites W2082605203 @default.
• W2153914897 cites W2106867441 @default.
• W2153914897 cites W2108195399 @default.
• W2153914897 cites W2112848473 @default.
• W2153914897 cites W2122182683 @default.
• W2153914897 cites W2131706101 @default.
• W2153914897 cites W2337157181 @default.
• W2153914897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3079589" @default.
• W2153914897 hasPublicationYear "1986" @default.
• W2153914897 type Work @default.
• W2153914897 sameAs 2153914897 @default.
• W2153914897 citedByCount "38" @default.
• W2153914897 countsByYear W21539148972014 @default.
• W2153914897 countsByYear W21539148972016 @default.
• W2153914897 countsByYear W21539148972018 @default.
• W2153914897 countsByYear W21539148972019 @default.
• W2153914897 countsByYear W21539148972021 @default.
• W2153914897 countsByYear W21539148972022 @default.
• W2153914897 crossrefType "journal-article" @default.
• W2153914897 hasAuthorship W2153914897A5007546821 @default.
• W2153914897 hasAuthorship W2153914897A5028028874 @default.
• W2153914897 hasAuthorship W2153914897A5028669896 @default.
• W2153914897 hasAuthorship W2153914897A5056175990 @default.
• W2153914897 hasAuthorship W2153914897A5062210857 @default.
• W2153914897 hasAuthorship W2153914897A5083523436 @default.
• W2153914897 hasConcept C142724271 @default.
• W2153914897 hasConcept C147483822 @default.
• W2153914897 hasConcept C159654299 @default.
• W2153914897 hasConcept C188280979 @default.
• W2153914897 hasConcept C203014093 @default.
• W2153914897 hasConcept C2777658100 @default.
• W2153914897 hasConcept C2778236600 @default.
• W2153914897 hasConcept C502942594 @default.
• W2153914897 hasConcept C542903549 @default.
• W2153914897 hasConcept C71924100 @default.
• W2153914897 hasConcept C86803240 @default.
• W2153914897 hasConceptScore W2153914897C142724271 @default.
• W2153914897 hasConceptScore W2153914897C147483822 @default.
• W2153914897 hasConceptScore W2153914897C159654299 @default.
• W2153914897 hasConceptScore W2153914897C188280979 @default.
• W2153914897 hasConceptScore W2153914897C203014093 @default.
• W2153914897 hasConceptScore W2153914897C2777658100 @default.
• W2153914897 hasConceptScore W2153914897C2778236600 @default.
• W2153914897 hasConceptScore W2153914897C502942594 @default.
• W2153914897 hasConceptScore W2153914897C542903549 @default.
• W2153914897 hasConceptScore W2153914897C71924100 @default.
• W2153914897 hasConceptScore W2153914897C86803240 @default.
• W2153914897 hasIssue "1" @default.
• W2153914897 hasLocation W21539148971 @default.
• W2153914897 hasOpenAccess W2153914897 @default.
• W2153914897 hasPrimaryLocation W21539148971 @default.
• W2153914897 hasRelatedWork W1977416344 @default.
• W2153914897 hasRelatedWork W1989289676 @default.
• W2153914897 hasRelatedWork W1997795358 @default.
• W2153914897 hasRelatedWork W2009889818 @default.
• W2153914897 hasRelatedWork W2029145496 @default.
• W2153914897 hasRelatedWork W2037509311 @default.
• W2153914897 hasRelatedWork W2073262237 @default.
• W2153914897 hasRelatedWork W2102639438 @default.
• W2153914897 hasRelatedWork W2317962315 @default.
• W2153914897 hasRelatedWork W2476973230 @default.
• W2153914897 hasVolume "46" @default.

• next