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• W2153915474 endingPage "31" @default.
• W2153915474 startingPage "31" @default.
• W2153915474 abstract "To evaluate the potential interference of trunk fat (TF) mass on metabolic and skeletal metabolism.In this cross-sectional study, 340 obese women (mean age: 44.8 ± 14 years; body mass index: 36.0 ± 5.9 kg/m(2)) were included. Patients were evaluated for serum vitamin D, osteocalcin (OSCA), inflammatory markers, lipids, glucose and insulin (homeostasis model assessment of insulin resistance, HOMA-IR) levels, and hormones profile. Moreover, all patients underwent measurements of bone mineral density (BMD; at lumbar and hip site) and body composition (lean mass, total and trunk fat mass) by dual-energy X-ray absorptiometry.Data showed that: (1) high TF mass was inversely correlated with low BMD both at lumbar (P < 0.001) and hip (P < 0.01) sites and with serum vitamin D (P < 0.0005), OSCA (P < 0.0001) and insulin-like growth factor-1 (IGF-1; P < 0.0001) levels; (2) a positive correlation was found between TF and HOMA-IR (P < 0.01), fibrinogen (P < 0.0001) and erythrocyte sedimentation rate (P < 0.0001); (3) vitamin D levels were directly correlated with IGF-1 (P < 0.0005), lumbar (P < 0.006) and hip (P < 0.01) BMD; and (4) inversely with HOMA-IR (P < 0.001) and fibrinogen (P < 0.0005).Multivariate analysis demonstrated that only vitamin D was independent of TF variable.In obese women, TF negatively correlates with BMD independently from vitamin D levels. Reduced IGF-1 and increased inflammatory markers might be some important determinants that account for this relationship." @default.
• W2153915474 created "2016-06-24" @default.
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• W2153915474 date "2013-01-01" @default.
• W2153915474 modified "2023-09-26" @default.
• W2153915474 title "Negative association between trunk fat, insulin resistance and skeleton in obese women" @default.
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• W2153915474 doi "https://doi.org/10.4239/wjd.v4.i2.31" @default.
• W2153915474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627415" @default.
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