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- W2153923118 endingPage "47" @default.
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- W2153923118 abstract "Macrolide antibiotics bind in the nascent peptide exit tunnel of the ribosome and inhibit protein synthesis. The majority of information on the principles of binding and action of these antibiotics comes from studies that employed model organisms. However, there is a growing understanding that the binding of macrolides to their target, as well as the mode of inhibition of translation, can be strongly influenced by variations in ribosome structure between bacterial species. Awareness of the existence of species‐specific differences in drug action and appreciation of the extent of these differences can stimulate future work on developing better macrolide drugs. In this review, representative cases illustrating the organism‐specific binding and action of macrolide antibiotics, as well as species‐specific mechanisms of resistance are analyzed." @default.
- W2153923118 created "2016-06-24" @default.
- W2153923118 creator A5022417892 @default.
- W2153923118 creator A5071330928 @default.
- W2153923118 date "2011-12-01" @default.
- W2153923118 modified "2023-10-18" @default.
- W2153923118 title "Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action" @default.
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- W2153923118 doi "https://doi.org/10.1111/j.1749-6632.2011.06315.x" @default.
- W2153923118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22191525" @default.
- W2153923118 hasPublicationYear "2011" @default.
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