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• W2153930945 endingPage "2381" @default.
• W2153930945 startingPage "2370" @default.
• W2153930945 abstract "ABSTRACT Activation of the two ubiquitous families of protein kinases, protein kinase A (PKA) and protein kinase C (PKC), is thought to be independently coupled to stimulation of Gα s and Gα q , respectively. Live-cell confocal imaging of protein kinase C fluorescent protein fusion constructs revealed that simultaneous activation of Gα s and Gα q resulted in a differential translocation of the conventional PKCα to the plasma membrane while the novel PKCδ was recruited to the membrane of the endoplasmic reticulum (ER). We demonstrate that the PKCδ translocation was driven by a novel Gα s -cyclic AMP-EPAC-RAP-PLCε pathway resulting in specific diacylglycerol production at the membrane of the ER. Membrane-specific phosphorylation sensors revealed that directed translocation resulted in phosphorylation activity confined to the target membrane. Specific stimulation of PKCδ caused phosphorylation of the inositol-1,4,5-trisphosphate receptor and dampening of global Ca 2+ signaling revealed by graded flash photolysis of caged inositol-1,4,5-trisphosphate. Our data demonstrate a novel signaling pathway enabling differential decoding of incoming stimuli into PKC isoform-specific membrane targeting, significantly enhancing the versatility of cyclic AMP signaling, thus demonstrating the possible interconnection between the PKA and PKC pathways traditionally treated independently. We thus provide novel and elementary understanding and insights into intracellular signaling events." @default.
• W2153930945 created "2016-06-24" @default.
• W2153930945 creator A5019040920 @default.
• W2153930945 creator A5071327421 @default.
• W2153930945 creator A5084121398 @default.
• W2153930945 creator A5088837946 @default.
• W2153930945 date "2014-07-01" @default.
• W2153930945 modified "2023-10-14" @default.
• W2153930945 title "Targeted Activation of Conventional and Novel Protein Kinases C through Differential Translocation Patterns" @default.
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• W2153930945 doi "https://doi.org/10.1128/mcb.00040-14" @default.
• W2153930945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4054312" @default.
• W2153930945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24732802" @default.
• W2153930945 hasPublicationYear "2014" @default.
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