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• W2153953669 abstract "Purpose Interstitial brachytherapy (IBT) is a preferred treatment option over partial penectomy in selected patients with T1–T2-stage penile carcinoma because of its organ preservation ability. Literature is mostly based on the use of low-dose-rate IBT, and experience with high-dose-rate (HDR) IBT is extremely limited. We studied the role of HDR-IBT alone in patients with T1–T2-stage penile carcinoma. Methods and Materials Between April 2010 and July 2013, 14 patients with T1–T2-stage penile carcinoma were treated with HDR-IBT at our center. Size of the primary lesion ranged from 1.5 to 4.0 cm. A two-to-four–plane free-hand implant was performed using plastic catheters. The prescribed dose of HDR-IBT was 42–51 Gy in 14–17 fractions using twice-a-day fractionation schedule. Patients were followed up regularly for assessment of local control, survival, toxicity, and sexual function. Results At a median followup of 22 months, 2 patients developed recurrent disease at locoregional site. The 3-year overall survival was 83% with penis preservation rate of 93%. All patients developed acute Grade III skin toxicity that healed during 6–8-weeks time. Urethral stenosis and soft tissue necrosis was not seen in any of the patients. A total of 4 patients experienced mild asymptomatic fibrosis in the implanted area. Around 10 patients had satisfactory sexual function status at the last followup visit. Conclusions Although it was a small sample size, our results have demonstrated excellent local control rate and acceptable toxicity with HDR-IBT in patients with T1–T2-stage penile carcinoma." @default.
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• W2153953669 date "2014-09-01" @default.
• W2153953669 modified "2023-10-16" @default.
• W2153953669 title "High-dose-rate interstitial brachytherapy for T1–T2-stage penile carcinoma: Short-term results" @default.
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• W2153953669 doi "https://doi.org/10.1016/j.brachy.2014.06.003" @default.
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