Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153986287> ?p ?o ?g. }
- W2153986287 endingPage "S104" @default.
- W2153986287 startingPage "S104" @default.
- W2153986287 abstract "Heparin-induced thrombocytopenia (HIT) results from an atypical immune response to platelet factor 4/heparin complexes (PF4/H), with rapid synthesis of platelet-activating IgG antibodies that activate platelets via FcgRIIa receptors. Protein tyrosine kinases (PTKs) and phosphatases (PTPs) are crucial for regulating immune responses and signaling pathways involved during platelet activation induced by collagen or IgG antibodies that crosslink FcgRIIa receptors. Among PTKs, Src family kinases (SFK) play an important role in platelet adhesion, activation, and aggregation. In addition, CD148, a receptor-like PTP, was recently showed to be critical for regulating SKF activation in platelets and positively regulates thrombus formation in mice. We therefore investigated whether an association may exist between 3 single nucleotide polymorphisms (SNPs) of CD148 i.e. Q276P, R326Q and D872E and the development of antibodies to PF4/H and HIT. We also evaluated whether CD148 genotypes may influence platelet aggregation and signaling triggered by collagen and HIT antibodies." @default.
- W2153986287 created "2016-06-24" @default.
- W2153986287 creator A5004622716 @default.
- W2153986287 creator A5013650708 @default.
- W2153986287 creator A5018171524 @default.
- W2153986287 creator A5026280438 @default.
- W2153986287 creator A5029047011 @default.
- W2153986287 creator A5077825698 @default.
- W2153986287 creator A5081552914 @default.
- W2153986287 creator A5083661496 @default.
- W2153986287 creator A5090355780 @default.
- W2153986287 date "2012-10-01" @default.
- W2153986287 modified "2023-10-05" @default.
- W2153986287 title "C0343 Polymorphisms of protein tyrosine phosphatase CD148 influence Fcgammariia-dependent platelet activation and the risk of heparin-induced thrombocytopenia" @default.
- W2153986287 cites W1481807902 @default.
- W2153986287 cites W1536411433 @default.
- W2153986287 cites W1585974360 @default.
- W2153986287 cites W1965875493 @default.
- W2153986287 cites W1969148038 @default.
- W2153986287 cites W1971434385 @default.
- W2153986287 cites W1974119746 @default.
- W2153986287 cites W1974461500 @default.
- W2153986287 cites W1975322052 @default.
- W2153986287 cites W1979438759 @default.
- W2153986287 cites W1990981421 @default.
- W2153986287 cites W1992571105 @default.
- W2153986287 cites W1997890715 @default.
- W2153986287 cites W2000179100 @default.
- W2153986287 cites W2018541786 @default.
- W2153986287 cites W2024305286 @default.
- W2153986287 cites W2026298111 @default.
- W2153986287 cites W2037072202 @default.
- W2153986287 cites W2040663231 @default.
- W2153986287 cites W2041622297 @default.
- W2153986287 cites W2053465902 @default.
- W2153986287 cites W2053593414 @default.
- W2153986287 cites W2063055656 @default.
- W2153986287 cites W2071165514 @default.
- W2153986287 cites W2071961135 @default.
- W2153986287 cites W2072793509 @default.
- W2153986287 cites W2074478484 @default.
- W2153986287 cites W2076599358 @default.
- W2153986287 cites W2082706608 @default.
- W2153986287 cites W2092283128 @default.
- W2153986287 cites W2097221124 @default.
- W2153986287 cites W2117980944 @default.
- W2153986287 cites W2121476395 @default.
- W2153986287 cites W2160241168 @default.
- W2153986287 cites W2164820930 @default.
- W2153986287 cites W2336478335 @default.
- W2153986287 cites W2416296623 @default.
- W2153986287 doi "https://doi.org/10.1016/j.thromres.2012.08.013" @default.
- W2153986287 hasPublicationYear "2012" @default.
- W2153986287 type Work @default.
- W2153986287 sameAs 2153986287 @default.
- W2153986287 citedByCount "1" @default.
- W2153986287 countsByYear W21539862872014 @default.
- W2153986287 crossrefType "journal-article" @default.
- W2153986287 hasAuthorship W2153986287A5004622716 @default.
- W2153986287 hasAuthorship W2153986287A5013650708 @default.
- W2153986287 hasAuthorship W2153986287A5018171524 @default.
- W2153986287 hasAuthorship W2153986287A5026280438 @default.
- W2153986287 hasAuthorship W2153986287A5029047011 @default.
- W2153986287 hasAuthorship W2153986287A5077825698 @default.
- W2153986287 hasAuthorship W2153986287A5081552914 @default.
- W2153986287 hasAuthorship W2153986287A5083661496 @default.
- W2153986287 hasAuthorship W2153986287A5090355780 @default.
- W2153986287 hasConcept C108636557 @default.
- W2153986287 hasConcept C159654299 @default.
- W2153986287 hasConcept C159973064 @default.
- W2153986287 hasConcept C170493617 @default.
- W2153986287 hasConcept C185592680 @default.
- W2153986287 hasConcept C203014093 @default.
- W2153986287 hasConcept C2776472838 @default.
- W2153986287 hasConcept C2777557582 @default.
- W2153986287 hasConcept C3018697912 @default.
- W2153986287 hasConcept C42362537 @default.
- W2153986287 hasConcept C55493867 @default.
- W2153986287 hasConcept C62478195 @default.
- W2153986287 hasConcept C85528070 @default.
- W2153986287 hasConcept C86803240 @default.
- W2153986287 hasConcept C8891405 @default.
- W2153986287 hasConcept C89560881 @default.
- W2153986287 hasConcept C95444343 @default.
- W2153986287 hasConceptScore W2153986287C108636557 @default.
- W2153986287 hasConceptScore W2153986287C159654299 @default.
- W2153986287 hasConceptScore W2153986287C159973064 @default.
- W2153986287 hasConceptScore W2153986287C170493617 @default.
- W2153986287 hasConceptScore W2153986287C185592680 @default.
- W2153986287 hasConceptScore W2153986287C203014093 @default.
- W2153986287 hasConceptScore W2153986287C2776472838 @default.
- W2153986287 hasConceptScore W2153986287C2777557582 @default.
- W2153986287 hasConceptScore W2153986287C3018697912 @default.
- W2153986287 hasConceptScore W2153986287C42362537 @default.
- W2153986287 hasConceptScore W2153986287C55493867 @default.
- W2153986287 hasConceptScore W2153986287C62478195 @default.
- W2153986287 hasConceptScore W2153986287C85528070 @default.
- W2153986287 hasConceptScore W2153986287C86803240 @default.