FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153997364> ?p ?o ?g. }

• W2153997364 endingPage "5095" @default.
• W2153997364 startingPage "5086" @default.
• W2153997364 abstract "Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that FGF19 transgenic tumors have an activated Wnt-pathway phenotype. Wnt signaling is implicated in initiating or promoting FGF signaling in various cell types and organs. In this study, we examined whether FGF19 or inhibition of FGF19 affects the beta-catenin signaling pathway using human colon cancer cell lines (HCT116, Colo201). Our results show that FGF19 increases tyrosine phosphorylation of beta-catenin and causes loss of beta-catenin-E-cadherin binding. FGF19 increases p-GSK3beta and active beta-catenin levels and anti-FGF19 antibody (1A6) treatment abrogates this effect of FGF19. Anti-FGF19 antibody treatment increases S33/S37/T41 phosphorylation and ubiquitination of beta-catenin. Ion-trap mass spectrometric analysis confirmed that 1A6 increases phosphorylation of beta-catenin in the NH(2) terminus. Using HCT116-paired beta-catenin knockout cells, we show that FGF19 induces TCF/LEF reporter activity in parental (WT/Delta45) and in WT/--but not in mutant (-/Delta45) cells, and that inhibition of endogenous FGF19 reduces this reporter activity, indicating that wild-type beta-catenin is accessible for modulation. FGFR4 knockdown using inducible short hairpin RNA significantly reduces the colony-forming ability in vitro and tumor growth in vivo. Although cleaved caspase-3 immunoreactivity remains unchanged, the number of ki67-positive nuclei is reduced in FGFR4 knockdown tumor xenograft tissues. Consistent with the reduced beta-catenin activation, Taqman analyses show that FGF19/FGFR4 inhibition reduced beta-catenin target gene (cyclin D1, CD44, c-jun, Cox-2, UPAR) expression. These findings highlight that FGF19/FGFR4 cross-talk with beta-catenin and that pathway intervention reduces tumor growth." @default.
• W2153997364 created "2016-06-24" @default.
• W2153997364 creator A5039500475 @default.
• W2153997364 creator A5044228668 @default.
• W2153997364 creator A5054567757 @default.
• W2153997364 creator A5069234901 @default.
• W2153997364 creator A5070560575 @default.
• W2153997364 creator A5079200349 @default.
• W2153997364 date "2008-07-01" @default.
• W2153997364 modified "2023-09-24" @default.
• W2153997364 title "Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating β-Catenin Signaling" @default.
• W2153997364 cites W1539520316 @default.
• W2153997364 cites W1777605394 @default.
• W2153997364 cites W1908612571 @default.
• W2153997364 cites W1967137553 @default.
• W2153997364 cites W1970147973 @default.
• W2153997364 cites W1990798651 @default.
• W2153997364 cites W2005865365 @default.
• W2153997364 cites W2013620862 @default.
• W2153997364 cites W2028134580 @default.
• W2153997364 cites W2035252744 @default.
• W2153997364 cites W2040942754 @default.
• W2153997364 cites W2041643931 @default.
• W2153997364 cites W2042055907 @default.
• W2153997364 cites W2048154391 @default.
• W2153997364 cites W2050147020 @default.
• W2153997364 cites W2050642264 @default.
• W2153997364 cites W2052690509 @default.
• W2153997364 cites W2053086049 @default.
• W2153997364 cites W2058212333 @default.
• W2153997364 cites W2062096656 @default.
• W2153997364 cites W2063746351 @default.
• W2153997364 cites W2067318470 @default.
• W2153997364 cites W2071601082 @default.
• W2153997364 cites W2076499218 @default.
• W2153997364 cites W2076892771 @default.
• W2153997364 cites W2077673213 @default.
• W2153997364 cites W2081985759 @default.
• W2153997364 cites W2082387343 @default.
• W2153997364 cites W2091605975 @default.
• W2153997364 cites W2092262813 @default.
• W2153997364 cites W2093423091 @default.
• W2153997364 cites W2093531978 @default.
• W2153997364 cites W2101998219 @default.
• W2153997364 cites W2104490911 @default.
• W2153997364 cites W2107648723 @default.
• W2153997364 cites W2109016302 @default.
• W2153997364 cites W2122892477 @default.
• W2153997364 cites W2124008135 @default.
• W2153997364 cites W2132834292 @default.
• W2153997364 cites W2148294117 @default.
• W2153997364 cites W2148388780 @default.
• W2153997364 cites W2157452165 @default.
• W2153997364 cites W2157467930 @default.
• W2153997364 cites W2239090104 @default.
• W2153997364 cites W2314458206 @default.
• W2153997364 cites W2442275722 @default.
• W2153997364 cites W65155625 @default.
• W2153997364 doi "https://doi.org/10.1158/0008-5472.can-07-2325" @default.
• W2153997364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18593907" @default.
• W2153997364 hasPublicationYear "2008" @default.
• W2153997364 type Work @default.
• W2153997364 sameAs 2153997364 @default.
• W2153997364 citedByCount "110" @default.
• W2153997364 countsByYear W21539973642012 @default.
• W2153997364 countsByYear W21539973642013 @default.
• W2153997364 countsByYear W21539973642014 @default.
• W2153997364 countsByYear W21539973642015 @default.
• W2153997364 countsByYear W21539973642016 @default.
• W2153997364 countsByYear W21539973642017 @default.
• W2153997364 countsByYear W21539973642018 @default.
• W2153997364 countsByYear W21539973642019 @default.
• W2153997364 countsByYear W21539973642020 @default.
• W2153997364 countsByYear W21539973642021 @default.
• W2153997364 countsByYear W21539973642022 @default.
• W2153997364 countsByYear W21539973642023 @default.
• W2153997364 crossrefType "journal-article" @default.
• W2153997364 hasAuthorship W2153997364A5039500475 @default.
• W2153997364 hasAuthorship W2153997364A5044228668 @default.
• W2153997364 hasAuthorship W2153997364A5054567757 @default.
• W2153997364 hasAuthorship W2153997364A5069234901 @default.
• W2153997364 hasAuthorship W2153997364A5070560575 @default.
• W2153997364 hasAuthorship W2153997364A5079200349 @default.
• W2153997364 hasBestOaLocation W21539973641 @default.
• W2153997364 hasConcept C11960822 @default.
• W2153997364 hasConcept C137620995 @default.
• W2153997364 hasConcept C153911025 @default.
• W2153997364 hasConcept C170493617 @default.
• W2153997364 hasConcept C173396325 @default.
• W2153997364 hasConcept C185592680 @default.
• W2153997364 hasConcept C2775936931 @default.
• W2153997364 hasConcept C2777553839 @default.
• W2153997364 hasConcept C502942594 @default.
• W2153997364 hasConcept C54355233 @default.
• W2153997364 hasConcept C55493867 @default.
• W2153997364 hasConcept C62478195 @default.
• W2153997364 hasConcept C66400584 @default.
• W2153997364 hasConcept C74373430 @default.

• next