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• W2154011403 endingPage "212" @default.
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• W2154011403 abstract "The crystal structure of human alpha class glutathione transferass A1-1 has been determined and refined to a resolution of 2·6 Å. There are two copies of the dimeric enzyme in the asymmetric unit. Each monomer is built from two domains. A bound inhibitor, S-benzyl-glutathione, is primarily associated with one of these domains via a network of hydrogen bonds and salt-links. In particular, the sulphur atom of the inhibitor forms a hydrogen bond to the hydroxyl group of Tyr9 and the guanido group of Arg15. The benzyl group of the inhibitor is completely buried in a hydrophobic pocket. The structure shows an overall similarity to the mn and pi class enzymes particularly in the glutathione-binding domain. The main difference concerns the extended C terminus of the alpha class enzyme which forms an extra α-helix that blocks one entrance to the active site and makes up part of the substrate binding site." @default.
• W2154011403 created "2016-06-24" @default.
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• W2154011403 date "1993-07-01" @default.
• W2154011403 modified "2023-10-16" @default.
• W2154011403 title "Structure Determination and Refinement of Human Alpha Class Glutathione Transferase A1-1, and a Comparison with the Mu and Pi Class Enzymes" @default.
• W2154011403 doi "https://doi.org/10.1006/jmbi.1993.1376" @default.
• W2154011403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8331657" @default.
• W2154011403 hasPublicationYear "1993" @default.
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