FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154021171> ?p ?o ?g. }

• W2154021171 endingPage "1698" @default.
• W2154021171 startingPage "1694" @default.
• W2154021171 abstract "BackgroundApproximately 30% of hemophilia A (HA) and 5% of hemophilia B patients develop inhibitors to protein replacement therapy, and this is the major cause of disease‐related morbidity in the developed world. We previously developed zymogen‐like factor Xa (FXa) molecules with impaired active site maturation, enabling a greater half‐life than wild‐type FXa while maintaining full procoagulant function in the prothrombinase complex. Here we evaluated the ability of zymogen‐like FXaI16L to correct whole blood thromboelastometry abnormalities of severe HA subjects with and without inhibitors.MethodsFourteen severe HA subjects without and five with inhibitors were enrolled at baseline (FVIII:C < 1%) > 5 half‐lives from factor or bypass therapy. The subjects' whole blood was evaluated by thromboelastography (ROTEM®) using INTEM analysis with two concentrations of FXaI16L or recombinant factor VIIa (rFVIIa).ResultsWith 0.1 nm FXaI16L, clot time (CT, in minutes [min]) among HA subjects without and with inhibitors (mean = 2.87 min, 95% CI = 2.58–3.15 min, and mean = 2.9 min, 95% CI = 2.07–3.73 min, respectively) did not significantly differ from control CT (mean = 2.73 min, 95% CI = 2.62–2.85 min). Addition of 20 nm rFVIIa, simulating a 90‐μg/kg dose, resulted in significantly prolonged CTs for HA subjects without and with inhibitors (mean = 5.43 min, 95% CI = 4.53–6.35 min, and mean = 4.25 min, 95% CI = 3.32–5.17 min, respectively) relative to controls.ConclusionsFXaI16L restored thromboelastometry CT to control values in severe HA subjects with and without inhibitors. The findings corroborate previous animal data and demonstrate the first evidence of zymogen‐like FXaI16L correcting human HA subjects' whole‐blood abnormalities and support the use of FXaI16L as a novel hemostatic agent." @default.
• W2154021171 created "2016-06-24" @default.
• W2154021171 creator A5013962604 @default.
• W2154021171 creator A5015452205 @default.
• W2154021171 creator A5047366587 @default.
• W2154021171 creator A5052567738 @default.
• W2154021171 creator A5056348530 @default.
• W2154021171 date "2015-09-01" @default.
• W2154021171 modified "2023-10-18" @default.
• W2154021171 title "Correction of human hemophilia A whole blood abnormalities with a novel bypass agent: zymogen‐like FXaI16L" @default.
• W2154021171 cites W1518197977 @default.
• W2154021171 cites W1541829031 @default.
• W2154021171 cites W1603649726 @default.
• W2154021171 cites W1970342224 @default.
• W2154021171 cites W1980229644 @default.
• W2154021171 cites W1985887837 @default.
• W2154021171 cites W1992502443 @default.
• W2154021171 cites W2002041775 @default.
• W2154021171 cites W2005959990 @default.
• W2154021171 cites W2011753037 @default.
• W2154021171 cites W2046550253 @default.
• W2154021171 cites W2067691677 @default.
• W2154021171 cites W2072336447 @default.
• W2154021171 cites W2079074570 @default.
• W2154021171 cites W2102709232 @default.
• W2154021171 cites W2117437723 @default.
• W2154021171 cites W2130322126 @default.
• W2154021171 cites W2134477676 @default.
• W2154021171 cites W2156626655 @default.
• W2154021171 cites W2168251691 @default.
• W2154021171 cites W2169051161 @default.
• W2154021171 cites W2324395680 @default.
• W2154021171 cites W4235028274 @default.
• W2154021171 cites W62994428 @default.
• W2154021171 doi "https://doi.org/10.1111/jth.13059" @default.
• W2154021171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26190406" @default.
• W2154021171 hasPublicationYear "2015" @default.
• W2154021171 type Work @default.
• W2154021171 sameAs 2154021171 @default.
• W2154021171 citedByCount "13" @default.
• W2154021171 countsByYear W21540211712016 @default.
• W2154021171 countsByYear W21540211712017 @default.
• W2154021171 countsByYear W21540211712018 @default.
• W2154021171 countsByYear W21540211712019 @default.
• W2154021171 countsByYear W21540211712020 @default.
• W2154021171 countsByYear W21540211712021 @default.
• W2154021171 countsByYear W21540211712022 @default.
• W2154021171 countsByYear W21540211712023 @default.
• W2154021171 crossrefType "journal-article" @default.
• W2154021171 hasAuthorship W2154021171A5013962604 @default.
• W2154021171 hasAuthorship W2154021171A5015452205 @default.
• W2154021171 hasAuthorship W2154021171A5047366587 @default.
• W2154021171 hasAuthorship W2154021171A5052567738 @default.
• W2154021171 hasAuthorship W2154021171A5056348530 @default.
• W2154021171 hasBestOaLocation W21540211711 @default.
• W2154021171 hasConcept C112516734 @default.
• W2154021171 hasConcept C126322002 @default.
• W2154021171 hasConcept C141071460 @default.
• W2154021171 hasConcept C1621761 @default.
• W2154021171 hasConcept C181199279 @default.
• W2154021171 hasConcept C185592680 @default.
• W2154021171 hasConcept C26809991 @default.
• W2154021171 hasConcept C2777292125 @default.
• W2154021171 hasConcept C2777664302 @default.
• W2154021171 hasConcept C2778382381 @default.
• W2154021171 hasConcept C2778775115 @default.
• W2154021171 hasConcept C2778961111 @default.
• W2154021171 hasConcept C42219234 @default.
• W2154021171 hasConcept C55493867 @default.
• W2154021171 hasConcept C71924100 @default.
• W2154021171 hasConcept C89560881 @default.
• W2154021171 hasConcept C90924648 @default.
• W2154021171 hasConceptScore W2154021171C112516734 @default.
• W2154021171 hasConceptScore W2154021171C126322002 @default.
• W2154021171 hasConceptScore W2154021171C141071460 @default.
• W2154021171 hasConceptScore W2154021171C1621761 @default.
• W2154021171 hasConceptScore W2154021171C181199279 @default.
• W2154021171 hasConceptScore W2154021171C185592680 @default.
• W2154021171 hasConceptScore W2154021171C26809991 @default.
• W2154021171 hasConceptScore W2154021171C2777292125 @default.
• W2154021171 hasConceptScore W2154021171C2777664302 @default.
• W2154021171 hasConceptScore W2154021171C2778382381 @default.
• W2154021171 hasConceptScore W2154021171C2778775115 @default.
• W2154021171 hasConceptScore W2154021171C2778961111 @default.
• W2154021171 hasConceptScore W2154021171C42219234 @default.
• W2154021171 hasConceptScore W2154021171C55493867 @default.
• W2154021171 hasConceptScore W2154021171C71924100 @default.
• W2154021171 hasConceptScore W2154021171C89560881 @default.
• W2154021171 hasConceptScore W2154021171C90924648 @default.
• W2154021171 hasFunder F4320307765 @default.
• W2154021171 hasFunder F4320332161 @default.
• W2154021171 hasIssue "9" @default.
• W2154021171 hasLocation W21540211711 @default.
• W2154021171 hasLocation W21540211712 @default.
• W2154021171 hasOpenAccess W2154021171 @default.
• W2154021171 hasPrimaryLocation W21540211711 @default.
• W2154021171 hasRelatedWork W1563036944 @default.
• W2154021171 hasRelatedWork W1967010985 @default.

• next