FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154022523> ?p ?o ?g. }

• W2154022523 endingPage "475" @default.
• W2154022523 startingPage "459" @default.
• W2154022523 abstract "Protein disulfide isomerase (PDI) is a thiodisulfide oxidoreductase that catalyzes the formation, reduction and rearrangement of disulfide bonds in proteins of eukaryotes. The classical PDI has a signal peptide, two CXXCcontaining thioredoxin catalytic sites (a,a′), two noncatalytic thioredoxin fold domains (b,b′), an acidic domain (c) and a C-terminal endoplasmic reticulum (ER) retention signal. Although PDI resides in the ER where it mediates the folding of nascent polypeptides of the secretory pathway, we recently showed that PDI5 of Arabidopsis thaliana chaperones and inhibits cysteine proteases during trafficking to vacuoles prior to programmed cell death of the endothelium in developing seeds. Here we describe Arabidopsis PDI2, which shares a primary structure similar to that of classical PDI. Recombinant PDI2 is imported into ER-derived microsomes and complements the E. coli protein-folding mutant, dsbA. PDI2 interacted with proteins in both the ER and nucleus, including ER-resident protein folding chaperone, BiP1, and nuclear embryo transcription factor, MEE8. The PDI2-MEE8 interaction was confirmed to occur in vitro and in vivo. Transient expression of PDI2-GFP fusions in mesophyll protoplasts resulted in labeling of the ER, nucleus and vacuole. PDI2 is expressed in multiple tissues, with relatively high expression in seeds and root tips. Immunoelectron microscopy with GFP- and PDI2-specific antisera on transgenic seeds (PDI2-GFP) and wild type roots demonstrated that PDI2 was found in the secretory pathway (ER, Golgi, vacuole, cell wall) and the nuclei. Our results indicate that PDI2 mediates protein folding in the ER and has new functional roles in the nucleus." @default.
• W2154022523 created "2016-06-24" @default.
• W2154022523 creator A5005802104 @default.
• W2154022523 creator A5014563333 @default.
• W2154022523 creator A5021484050 @default.
• W2154022523 creator A5032849986 @default.
• W2154022523 creator A5042446424 @default.
• W2154022523 creator A5076568850 @default.
• W2154022523 date "2011-09-05" @default.
• W2154022523 modified "2023-10-01" @default.
• W2154022523 title "Protein disulfide isomerase-2 of Arabidopsis mediates protein folding and localizes to both the secretory pathway and nucleus, where it interacts with maternal effect embryo arrest factor" @default.
• W2154022523 cites W1495345604 @default.
• W2154022523 cites W1546139069 @default.
• W2154022523 cites W1851032489 @default.
• W2154022523 cites W1903792504 @default.
• W2154022523 cites W1975407498 @default.
• W2154022523 cites W1976649483 @default.
• W2154022523 cites W1977186059 @default.
• W2154022523 cites W1979302428 @default.
• W2154022523 cites W1980742599 @default.
• W2154022523 cites W1986797749 @default.
• W2154022523 cites W1989226450 @default.
• W2154022523 cites W1989700964 @default.
• W2154022523 cites W1991580924 @default.
• W2154022523 cites W1992395246 @default.
• W2154022523 cites W1994717043 @default.
• W2154022523 cites W1999773791 @default.
• W2154022523 cites W2003113075 @default.
• W2154022523 cites W2006991685 @default.
• W2154022523 cites W2011879824 @default.
• W2154022523 cites W2012564489 @default.
• W2154022523 cites W2014199958 @default.
• W2154022523 cites W2017240909 @default.
• W2154022523 cites W2018632843 @default.
• W2154022523 cites W2021348787 @default.
• W2154022523 cites W2022087931 @default.
• W2154022523 cites W2025598125 @default.
• W2154022523 cites W2026559943 @default.
• W2154022523 cites W2029112137 @default.
• W2154022523 cites W2030833413 @default.
• W2154022523 cites W2032734179 @default.
• W2154022523 cites W2033078445 @default.
• W2154022523 cites W2039780516 @default.
• W2154022523 cites W2041326548 @default.
• W2154022523 cites W2041910493 @default.
• W2154022523 cites W2042391360 @default.
• W2154022523 cites W2042958872 @default.
• W2154022523 cites W2045356023 @default.
• W2154022523 cites W2048093595 @default.
• W2154022523 cites W2049256648 @default.
• W2154022523 cites W2051008192 @default.
• W2154022523 cites W2051452587 @default.
• W2154022523 cites W2052821301 @default.
• W2154022523 cites W2055629661 @default.
• W2154022523 cites W2058274510 @default.
• W2154022523 cites W2063181752 @default.
• W2154022523 cites W2064508862 @default.
• W2154022523 cites W2067827181 @default.
• W2154022523 cites W2071247960 @default.
• W2154022523 cites W2072724927 @default.
• W2154022523 cites W2079294785 @default.
• W2154022523 cites W2085580153 @default.
• W2154022523 cites W2089370825 @default.
• W2154022523 cites W2093839543 @default.
• W2154022523 cites W2094171232 @default.
• W2154022523 cites W2094456663 @default.
• W2154022523 cites W2095115589 @default.
• W2154022523 cites W2095593063 @default.
• W2154022523 cites W2096086782 @default.
• W2154022523 cites W2097788615 @default.
• W2154022523 cites W2101714300 @default.
• W2154022523 cites W2104949747 @default.
• W2154022523 cites W2106982848 @default.
• W2154022523 cites W2110532131 @default.
• W2154022523 cites W2110564679 @default.
• W2154022523 cites W2112029698 @default.
• W2154022523 cites W2116122104 @default.
• W2154022523 cites W2118278390 @default.
• W2154022523 cites W2119179069 @default.
• W2154022523 cites W2129296954 @default.
• W2154022523 cites W2134899889 @default.
• W2154022523 cites W2135487705 @default.
• W2154022523 cites W2136280642 @default.
• W2154022523 cites W2137601093 @default.
• W2154022523 cites W2140788063 @default.
• W2154022523 cites W2141353547 @default.
• W2154022523 cites W2142379034 @default.
• W2154022523 cites W2142709713 @default.
• W2154022523 cites W2142946131 @default.
• W2154022523 cites W2146183177 @default.
• W2154022523 cites W2161746138 @default.
• W2154022523 cites W2162301917 @default.
• W2154022523 cites W2164539011 @default.
• W2154022523 cites W2165613108 @default.
• W2154022523 cites W2167068518 @default.
• W2154022523 cites W2167454511 @default.
• W2154022523 cites W2167459724 @default.
• W2154022523 cites W2171099519 @default.

• next