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• W2154023242 startingPage "71" @default.
• W2154023242 abstract "Previous studies have shown that the inflammatory response to cigarette smoking differs between smokers who acquire COPD and those who do not, and the CD8(+) T- lymphocytes have been identified as a key player in this response.To investigate the cytotoxic activity and perforin expression of CD8(+) lymphocytes in the airway lumen of patients with COPD.Thirty-six male smokers with COPD, 25 male smokers without COPD, and 10 healthy nonsmokers participated in the study. T-lymphocytes of induced sputum samples were labeled with appropriate monoclonal antibodies and measured using flow cytometry. The cytotoxic activity of CD8(+) cells was defined by incubating them with specific target cells (K562).The percentage and the total number of CD8(+) lymphocytes were significantly higher in COPD smokers compared to non-COPD smokers (p = 0.01 and p = 0.005, respectively) or to healthy nonsmokers (p = 0.02 and p = 0.01, respectively). Perforin expression in CD8(+) cells was significantly higher in smokers with COPD compared to the other two groups (p = 0.001). Increased cytotoxic activity of T cells was also observed in induced sputum of patients with COPD in comparison to the other two groups.CD8(+) cells are not only increased in number in sputum samples of smokers with COPD but are highly activated, expressing high levels of perforin. These findings suggest that CD8(+) T-lymphocytes play a significant role in the inflammatory process of COPD." @default.
• W2154023242 created "2016-06-24" @default.
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• W2154023242 date "2004-01-01" @default.
• W2154023242 modified "2023-10-16" @default.
• W2154023242 title "Perforin Expression and Cytotoxic Activity of Sputum CD8 + Lymphocytes in Patients With COPD" @default.
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• W2154023242 doi "https://doi.org/10.1378/chest.125.1.71" @default.
• W2154023242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14718423" @default.
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