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• W2154041714 abstract "The purpose of this study was to identify the affect on the proliferation Eca-109 cells treated with oxidized low-density lipoprotein (ox-LDL) combined with adriamycin (ADM).Eca-109 cell were cultured in the presence of oxLDL/ADM, and cell proliferation tested by MTT and cell apoptosis was monitored by the proportion of apoptosis and cell cycle by flow cytomester. We simultaneously evaluated the level of associated- apoptosis Bcl-2, Bax, and Caspase-3 gene mRNA and protein.OxLDL were cytotoxic and activate apoptosis. OxLDL combined with ADM significant enhanced the proportion rate of apoptosis on a time and dose dependency. The expressions of the inhibiting apoptosis Bcl-2 gene mRNA and protein were down regulated, whereas, the expressions of the promoting apoptosis Bax, and Caspase-3 genes mRNA and protein were up regulation.These results suggested that oxLDL have cytotoxicity and activate apoptosis on the Eca-109 cells. OxLDL combined with ADM have a synergistic effect on the apoptosis induced Eca-109 cells. Furthermore, oxLDL may contribute to the improvement of clinical chemotherapy of cancer need to make further investigation." @default.
• W2154041714 created "2016-06-24" @default.
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• W2154041714 date "2011-01-01" @default.
• W2154041714 modified "2023-10-03" @default.
• W2154041714 title "The effect of oxidized low-density lipoprotein combined with adriamycin on the proliferation of Eca-109 cell line" @default.
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• W2154041714 doi "https://doi.org/10.1186/1476-511x-10-108" @default.
• W2154041714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150309" @default.
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