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• W2154049957 abstract "Growth arrest-specific protein 6 (GAS6) is a soluble agonist of the TYRO3, AXL, MERTK (TAM) family of receptor tyrosine kinases identified to have anti-inflammatory, neuroprotective, and promyelinating properties. During experimental autoimmune encephalomyelitis (EAE), wild-type (WT) mice demonstrate a significant induction of Gas6 , Axl , and Mertk but not Pros1 or Tyro3 mRNA. We tested the hypothesis that intracerebroventricular delivery of GAS6 directly into the CNS of WT mice during myelin oligodendrocyte glycoprotein (MOG)-induced EAE would improve the clinical course of disease relative to artificial CSF (ACSF)-treated mice. GAS6 did not delay disease onset, but significantly reduced the clinical scores during peak and chronic EAE. Mice receiving GAS6 for 28 d had preserved SMI31 + neurofilament immunoreactivity, significantly fewer SMI32 + axonal swellings and spheroids and less demyelination relative to ACSF-treated mice. Alternate-day subcutaneous IFNβ injection did not enhance GAS6 treatment effectiveness. Gas6 −/− mice sensitized with MOG 35-55 peptide exhibit higher clinical scores during late peak to early chronic disease, with significantly increased SMI32 + axonal swellings and Iba1 + microglia/macrophages, enhanced expression of several proinflammatory mRNA molecules, and decreased expression of early oligodendrocyte maturation markers relative to WT mouse spinal cords with scores for 8 consecutive days. During acute EAE, flow cytometry showed significantly more macrophages but not T-cell infiltrates in Gas6 −/− spinal cords than WT spinal cords. Our data are consistent with GAS6 being protective during EAE by dampening the inflammatory response, thereby preserving axonal integrity and myelination." @default.
• W2154049957 created "2016-06-24" @default.
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• W2154049957 date "2014-12-03" @default.
• W2154049957 modified "2023-10-18" @default.
• W2154049957 title "Targeted GAS6 Delivery to the CNS Protects Axons from Damage during Experimental Autoimmune Encephalomyelitis" @default.
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• W2154049957 doi "https://doi.org/10.1523/jneurosci.2449-14.2014" @default.
• W2154049957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4252545" @default.
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