FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154078412> ?p ?o ?g. }

• W2154078412 abstract "Perioperative fluid therapy influences clinical outcomes following major surgery. Fluid preparations may be based on a simple non-buffered salt solution, such as normal saline, or may be modified with bicarbonate or bicarbonate precursor buffers, such as maleate, gluconate, lactate or acetate, to better reflect the human physiological state. These latter fluids have theoretical advantages over normal saline in preventing hyperchloraemic acidosis. A number of clinical studies have now compared fluid preparations with and without a buffer to achieve a balanced electrolyte solution for perioperative fluid resuscitation.To review the safety and efficacy of perioperative administration of buffered versus non-buffered fluids for plasma volume expansion or maintenance in adult patients undergoing surgery.We electronically searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2011, Issue 4), MEDLINE (1966 to May 2011), EMBASE (1980 to May 2011), and CINAHL (1982 to May 2011). We handsearched conference abstracts and where possible, contacted leaders in the field.We only included randomized trials of buffered versus non-buffered intravenous fluids for perioperative fluid resuscitation. The trials with other forms of comparisons such as crystalloids versus colloids and colloids versus different colloids were excluded. We also excluded trials using hypertonic fluids and dextrose-based fluids.Two authors independently extracted data and assessed the methodological quality of clinical trials. We resolved any disagreements by discussion. We contacted the trial authors to provide additional information where appropriate. We presented pooled estimates of the dichotomous outcomes as odds ratios (OR) and on continuous outcomes as mean differences, with 95% confidence intervals (CI). We analysed data on Review Manager 5.1 using fixed-effect models, and when heterogeneity was high (I² > 40%) random-effect models were used.We identified 14 publications reporting 13 trials or comparisons with a total of 706 participants. For many of the outcomes reported, there was significant clinical and statistical heterogeneity. The primary outcome of mortality at any time was reported in only three studies with a total of 267 patients. The mortality rate was 2.9% for the buffered fluids group and 1.5% for the non-buffered fluids group but this difference was not statistically significant. The Peto OR was 1.85 (95% CI 0.37 to 9.33, P = 0.45, I(2)= 0%). Organ dysfunction was only presented for renal impairment. There was no difference in renal insufficiency leading to renal replacement therapy between the buffered and non-buffered groups (OR 0.61, 95% CI 0.23 to 1.63, P = 0.32, I(2) = 0%). Markers of organ system failure as assessed by urine output, creatinine and its variables (for renal function), PaC0(2) (respiratory function) and postoperative nausea and vomiting (gastro-intestinal function) showed a statistically significant difference only in PaC0(2) levels. The mean difference was 1.18 with lower PaC0(2) levels in the non-buffered fluid group (95% CI 0.09 to 2.28, P = 0.03, I(2) = 0%) compared to the buffered fluid group.There was no difference in intraoperative blood loss nor the volumes of intraoperative red cell or fresh frozen plasma transfused between groups. There was an increase in platelet transfusion in the non-buffered group which was statistically significant after analysing the transformed data (log transformation because the data were highly skewed).A number of metabolic differences were noted. There was a difference in postoperative pH of 0.06 units, lower in the non-buffered fluid group (95% CI 0.04 to 0.08, P < 0.00001, I(2) = 74%). However, this difference was not maintained on postoperative day one. The non-buffered fluid group also had significantly greater base deficit, serum sodium and chloride levels.There was no difference demonstrated in length of hospital stay and no data were reported on cost or quality of life.The administration of buffered fluids to adult patients during surgery is equally safe and effective as the administration of non-buffered saline-based fluids. The use of buffered fluids is associated with less metabolic derangement, in particular hyperchloraemia and metabolic acidosis. Larger studies are needed to assess robust outcomes such as mortality." @default.
• W2154078412 created "2016-06-24" @default.
• W2154078412 creator A5029287147 @default.
• W2154078412 creator A5033253781 @default.
• W2154078412 creator A5034348478 @default.
• W2154078412 creator A5041146029 @default.
• W2154078412 creator A5052038379 @default.
• W2154078412 creator A5082689888 @default.
• W2154078412 creator A5083695025 @default.
• W2154078412 creator A5087208923 @default.
• W2154078412 creator A5088652167 @default.
• W2154078412 creator A5089582452 @default.
• W2154078412 creator A5091851614 @default.
• W2154078412 date "2012-12-12" @default.
• W2154078412 modified "2023-10-17" @default.
• W2154078412 title "Perioperative buffered versus non-buffered fluid administration for surgery in adults" @default.
• W2154078412 cites W1528229609 @default.
• W2154078412 cites W1537972189 @default.
• W2154078412 cites W1591259115 @default.
• W2154078412 cites W1899812833 @default.
• W2154078412 cites W1964870440 @default.
• W2154078412 cites W1971884075 @default.
• W2154078412 cites W1973738968 @default.
• W2154078412 cites W1977985705 @default.
• W2154078412 cites W1981173903 @default.
• W2154078412 cites W1987303342 @default.
• W2154078412 cites W1990435104 @default.
• W2154078412 cites W2010891042 @default.
• W2154078412 cites W2012446500 @default.
• W2154078412 cites W2012835199 @default.
• W2154078412 cites W2020449386 @default.
• W2154078412 cites W2027949365 @default.
• W2154078412 cites W2036740 @default.
• W2154078412 cites W2036864571 @default.
• W2154078412 cites W2044541001 @default.
• W2154078412 cites W2046856395 @default.
• W2154078412 cites W2054331417 @default.
• W2154078412 cites W2061809736 @default.
• W2154078412 cites W2066831337 @default.
• W2154078412 cites W2069115809 @default.
• W2154078412 cites W2070989396 @default.
• W2154078412 cites W2072634400 @default.
• W2154078412 cites W2080942352 @default.
• W2154078412 cites W2088783942 @default.
• W2154078412 cites W2093536899 @default.
• W2154078412 cites W2117005662 @default.
• W2154078412 cites W2122715588 @default.
• W2154078412 cites W2130994378 @default.
• W2154078412 cites W2131651728 @default.
• W2154078412 cites W2136522641 @default.
• W2154078412 cites W2145681716 @default.
• W2154078412 cites W2157823046 @default.
• W2154078412 cites W2159493837 @default.
• W2154078412 cites W4206080073 @default.
• W2154078412 cites W4229925036 @default.
• W2154078412 cites W4231328703 @default.
• W2154078412 cites W4234999869 @default.
• W2154078412 cites W4242653012 @default.
• W2154078412 cites W2016527979 @default.
• W2154078412 doi "https://doi.org/10.1002/14651858.cd004089.pub2" @default.
• W2154078412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23235602" @default.
• W2154078412 hasPublicationYear "2012" @default.
• W2154078412 type Work @default.
• W2154078412 sameAs 2154078412 @default.
• W2154078412 citedByCount "62" @default.
• W2154078412 countsByYear W21540784122013 @default.
• W2154078412 countsByYear W21540784122014 @default.
• W2154078412 countsByYear W21540784122015 @default.
• W2154078412 countsByYear W21540784122016 @default.
• W2154078412 countsByYear W21540784122017 @default.
• W2154078412 countsByYear W21540784122018 @default.
• W2154078412 countsByYear W21540784122019 @default.
• W2154078412 countsByYear W21540784122021 @default.
• W2154078412 countsByYear W21540784122022 @default.
• W2154078412 countsByYear W21540784122023 @default.
• W2154078412 crossrefType "reference-entry" @default.
• W2154078412 hasAuthorship W2154078412A5029287147 @default.
• W2154078412 hasAuthorship W2154078412A5033253781 @default.
• W2154078412 hasAuthorship W2154078412A5034348478 @default.
• W2154078412 hasAuthorship W2154078412A5041146029 @default.
• W2154078412 hasAuthorship W2154078412A5052038379 @default.
• W2154078412 hasAuthorship W2154078412A5082689888 @default.
• W2154078412 hasAuthorship W2154078412A5083695025 @default.
• W2154078412 hasAuthorship W2154078412A5087208923 @default.
• W2154078412 hasAuthorship W2154078412A5088652167 @default.
• W2154078412 hasAuthorship W2154078412A5089582452 @default.
• W2154078412 hasAuthorship W2154078412A5091851614 @default.
• W2154078412 hasConcept C126322002 @default.
• W2154078412 hasConcept C141071460 @default.
• W2154078412 hasConcept C156957248 @default.
• W2154078412 hasConcept C168563851 @default.
• W2154078412 hasConcept C2771230 @default.
• W2154078412 hasConcept C2778165595 @default.
• W2154078412 hasConcept C31174226 @default.
• W2154078412 hasConcept C42219234 @default.
• W2154078412 hasConcept C535046627 @default.
• W2154078412 hasConcept C71924100 @default.
• W2154078412 hasConcept C95190672 @default.
• W2154078412 hasConceptScore W2154078412C126322002 @default.
• W2154078412 hasConceptScore W2154078412C141071460 @default.

• next