FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154079085> ?p ?o ?g. }

• W2154079085 endingPage "18" @default.
• W2154079085 startingPage "11" @default.
• W2154079085 abstract "Temporal lobe epilepsy (TLE) is associated with febrile convulsions and childhood status epilepticus (SE). Since the initial precipitating injury, triggering epileptogenesis, occurs during this SE, we aimed to examine the metabolic and morphological cerebral changes during the acute phase of experimental SE noninvasively. In the rat lithium–pilocarpine model of SE, we performed quantified T2- and isotropic-diffusion-weighted (DW) magnetic resonance imaging (MRI) at 3 and 5 h of SE and acquired single-voxel 1H MR spectra at 2, 4 and 6 h of SE. T2 was globally decreased, most pronounced in the amygdala (Am) and piriformic cortex (Pi), in which also a significant decrease in apparent diffusion coefficient (ADC) was found. In contrast, ADC values increased transiently in the hippocampus (HC) and thalamus (Th). MR spectra showed a decrease in N-acetylaspartate (NAA) and choline (Cho) and an increase of lactate in a hippocampal voxel. Discussion: The T2 decrease, attributed to raised deoxyhemoglobin, and the presence of lactate both indicate a mismatch between oxygen demand and delivery. The ADC decrease, indicative of excitotoxicity, confirms that the amygdala and piriformic cortex are particularly vulnerable to lithium–pilocarpine-induced seizures. The transient ADC increase in the thalamus may reflect the breakdown of the blood–brain barrier (BBB), which is shown to occur in this region at these time points. Neuronal damage and failure of energy-dependent formation of NAA are likely causes of an observed decrease in NAA, while the decrease in Cho is possibly due to depletion of the cholinergic system. This study illustrates that relative hypoxia, excitotoxicity and concomitant neuronal damage associated with SE can be probed noninvasively with MR. These pathological phenomena are the first to contribute to the pathophysiology of spontaneous recurrent seizures in a later stage in this animal model." @default.
• W2154079085 created "2016-06-24" @default.
• W2154079085 creator A5010029432 @default.
• W2154079085 creator A5018892973 @default.
• W2154079085 creator A5036184021 @default.
• W2154079085 creator A5037061681 @default.
• W2154079085 creator A5042169674 @default.
• W2154079085 creator A5059792872 @default.
• W2154079085 creator A5064705806 @default.
• W2154079085 date "2004-12-01" @default.
• W2154079085 modified "2023-09-27" @default.
• W2154079085 title "In vivo 1H magnetic resonance spectroscopy, T2-weighted and diffusion-weighted MRI during lithium–pilocarpine-induced status epilepticus in the rat" @default.
• W2154079085 cites W1604229968 @default.
• W2154079085 cites W1964785025 @default.
• W2154079085 cites W1965857721 @default.
• W2154079085 cites W1967505584 @default.
• W2154079085 cites W1969465473 @default.
• W2154079085 cites W1974437785 @default.
• W2154079085 cites W1978810247 @default.
• W2154079085 cites W1981937012 @default.
• W2154079085 cites W1983413001 @default.
• W2154079085 cites W1984553976 @default.
• W2154079085 cites W1990005524 @default.
• W2154079085 cites W1997059788 @default.
• W2154079085 cites W1997962496 @default.
• W2154079085 cites W2001276905 @default.
• W2154079085 cites W2001336547 @default.
• W2154079085 cites W2003629952 @default.
• W2154079085 cites W2004368602 @default.
• W2154079085 cites W2011010090 @default.
• W2154079085 cites W2013511059 @default.
• W2154079085 cites W2014143021 @default.
• W2154079085 cites W2017674801 @default.
• W2154079085 cites W2029353462 @default.
• W2154079085 cites W2029627898 @default.
• W2154079085 cites W2034271730 @default.
• W2154079085 cites W2038623669 @default.
• W2154079085 cites W2038781348 @default.
• W2154079085 cites W2039631898 @default.
• W2154079085 cites W2041641505 @default.
• W2154079085 cites W2043379709 @default.
• W2154079085 cites W2045385574 @default.
• W2154079085 cites W2058027749 @default.
• W2154079085 cites W2073060882 @default.
• W2154079085 cites W2075169103 @default.
• W2154079085 cites W2077839370 @default.
• W2154079085 cites W2079159386 @default.
• W2154079085 cites W2084596340 @default.
• W2154079085 cites W2088381054 @default.
• W2154079085 cites W2093238337 @default.
• W2154079085 cites W2103376251 @default.
• W2154079085 cites W2115557128 @default.
• W2154079085 cites W2122632726 @default.
• W2154079085 cites W2145572652 @default.
• W2154079085 cites W2165254729 @default.
• W2154079085 cites W2166447911 @default.
• W2154079085 cites W2169137397 @default.
• W2154079085 cites W28565544 @default.
• W2154079085 doi "https://doi.org/10.1016/j.brainres.2004.09.025" @default.
• W2154079085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15567333" @default.
• W2154079085 hasPublicationYear "2004" @default.
• W2154079085 type Work @default.
• W2154079085 sameAs 2154079085 @default.
• W2154079085 citedByCount "54" @default.
• W2154079085 countsByYear W21540790852012 @default.
• W2154079085 countsByYear W21540790852013 @default.
• W2154079085 countsByYear W21540790852014 @default.
• W2154079085 countsByYear W21540790852015 @default.
• W2154079085 countsByYear W21540790852016 @default.
• W2154079085 countsByYear W21540790852017 @default.
• W2154079085 countsByYear W21540790852019 @default.
• W2154079085 countsByYear W21540790852021 @default.
• W2154079085 crossrefType "journal-article" @default.
• W2154079085 hasAuthorship W2154079085A5010029432 @default.
• W2154079085 hasAuthorship W2154079085A5018892973 @default.
• W2154079085 hasAuthorship W2154079085A5036184021 @default.
• W2154079085 hasAuthorship W2154079085A5037061681 @default.
• W2154079085 hasAuthorship W2154079085A5042169674 @default.
• W2154079085 hasAuthorship W2154079085A5059792872 @default.
• W2154079085 hasAuthorship W2154079085A5064705806 @default.
• W2154079085 hasConcept C121332964 @default.
• W2154079085 hasConcept C126838900 @default.
• W2154079085 hasConcept C134018914 @default.
• W2154079085 hasConcept C143409427 @default.
• W2154079085 hasConcept C15744967 @default.
• W2154079085 hasConcept C169760540 @default.
• W2154079085 hasConcept C185592680 @default.
• W2154079085 hasConcept C2777204577 @default.
• W2154079085 hasConcept C2777341932 @default.
• W2154079085 hasConcept C2778186239 @default.
• W2154079085 hasConcept C2779246727 @default.
• W2154079085 hasConcept C2781099131 @default.
• W2154079085 hasConcept C2781161787 @default.
• W2154079085 hasConcept C46141821 @default.
• W2154079085 hasConcept C57236427 @default.
• W2154079085 hasConcept C70816921 @default.
• W2154079085 hasConcept C71924100 @default.
• W2154079085 hasConceptScore W2154079085C121332964 @default.

• next