Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154084135> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2154084135 endingPage "260" @default.
- W2154084135 startingPage "255" @default.
- W2154084135 abstract "Abstract Apo(a) is a low density lipoprotein homologous to plasminogen and has been shown to be involved in coronary atherosclerosis. In the present paper we will try to analyze the interesting evolutionary pattern of Apo(a). The plasminogen gene contains 5 cysteine-rich sequences, called kringles, followed by a protease domain. Apo(a), probably arisen by duplication of an ancestral plasminogen gene, contains many tandemly repeated copies of a sequence domain similar to the fourth kringle of plasminogen, 37 in human and at least 10 in the partially sequenced gene of rhesus, and the protease domain. We have found that the upstream kringles of apo(a) undergo Molecular Drive-like processes that produce high intraspecies similarity, whereas the downstream kringles evolve in a molecular clock-like manner and show an high interspecies sequence similarity. The latter regions are obviously suitable for dating the duplication event by which Apo(a) arose from plasminogen, but only if they evolve at the same rate in the two genes. Thus, we propose a Molecular Clock Test for assessing whether the comparison of two paralogous genes (or gene regions) can give reliable information on the dating of their origin by duplication. Applying this test to the kringle-4 domain of apo(a) and plasminogen gene, we demonstrate that the separation between the two genes by duplication dates back at about 90 Mya immediately before the radiation of mammals." @default.
- W2154084135 created "2016-06-24" @default.
- W2154084135 creator A5005312066 @default.
- W2154084135 creator A5008716029 @default.
- W2154084135 creator A5055915244 @default.
- W2154084135 creator A5065212628 @default.
- W2154084135 date "1994-01-01" @default.
- W2154084135 modified "2023-10-17" @default.
- W2154084135 title "The peculiar evolution of apolipoprotein(a) in human and rhesus macaque." @default.
- W2154084135 cites W1413134897 @default.
- W2154084135 cites W1579972668 @default.
- W2154084135 cites W1593696386 @default.
- W2154084135 cites W1970055375 @default.
- W2154084135 cites W1972581857 @default.
- W2154084135 cites W1973135952 @default.
- W2154084135 cites W1981039801 @default.
- W2154084135 cites W1984684688 @default.
- W2154084135 cites W1987510089 @default.
- W2154084135 cites W2003061649 @default.
- W2154084135 cites W2010404086 @default.
- W2154084135 cites W2036170644 @default.
- W2154084135 cites W2048880173 @default.
- W2154084135 cites W2051790237 @default.
- W2154084135 cites W2054049732 @default.
- W2154084135 cites W2056643258 @default.
- W2154084135 cites W2102920246 @default.
- W2154084135 cites W2160741225 @default.
- W2154084135 cites W2181367295 @default.
- W2154084135 cites W2396377156 @default.
- W2154084135 cites W2443135943 @default.
- W2154084135 cites W2601913882 @default.
- W2154084135 doi "https://doi.org/10.1093/genetics/136.1.255" @default.
- W2154084135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1205777" @default.
- W2154084135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8138162" @default.
- W2154084135 hasPublicationYear "1994" @default.
- W2154084135 type Work @default.
- W2154084135 sameAs 2154084135 @default.
- W2154084135 citedByCount "9" @default.
- W2154084135 crossrefType "journal-article" @default.
- W2154084135 hasAuthorship W2154084135A5005312066 @default.
- W2154084135 hasAuthorship W2154084135A5008716029 @default.
- W2154084135 hasAuthorship W2154084135A5055915244 @default.
- W2154084135 hasAuthorship W2154084135A5065212628 @default.
- W2154084135 hasBestOaLocation W21540841351 @default.
- W2154084135 hasConcept C104317684 @default.
- W2154084135 hasConcept C150194340 @default.
- W2154084135 hasConcept C181199279 @default.
- W2154084135 hasConcept C2776714187 @default.
- W2154084135 hasConcept C2778112365 @default.
- W2154084135 hasConcept C54355233 @default.
- W2154084135 hasConcept C55493867 @default.
- W2154084135 hasConcept C5911399 @default.
- W2154084135 hasConcept C7602840 @default.
- W2154084135 hasConcept C86803240 @default.
- W2154084135 hasConceptScore W2154084135C104317684 @default.
- W2154084135 hasConceptScore W2154084135C150194340 @default.
- W2154084135 hasConceptScore W2154084135C181199279 @default.
- W2154084135 hasConceptScore W2154084135C2776714187 @default.
- W2154084135 hasConceptScore W2154084135C2778112365 @default.
- W2154084135 hasConceptScore W2154084135C54355233 @default.
- W2154084135 hasConceptScore W2154084135C55493867 @default.
- W2154084135 hasConceptScore W2154084135C5911399 @default.
- W2154084135 hasConceptScore W2154084135C7602840 @default.
- W2154084135 hasConceptScore W2154084135C86803240 @default.
- W2154084135 hasIssue "1" @default.
- W2154084135 hasLocation W21540841351 @default.
- W2154084135 hasLocation W21540841352 @default.
- W2154084135 hasLocation W21540841353 @default.
- W2154084135 hasOpenAccess W2154084135 @default.
- W2154084135 hasPrimaryLocation W21540841351 @default.
- W2154084135 hasRelatedWork W1593696386 @default.
- W2154084135 hasRelatedWork W1865538750 @default.
- W2154084135 hasRelatedWork W1883623662 @default.
- W2154084135 hasRelatedWork W1970055375 @default.
- W2154084135 hasRelatedWork W1973049607 @default.
- W2154084135 hasRelatedWork W1973135952 @default.
- W2154084135 hasRelatedWork W1998023491 @default.
- W2154084135 hasRelatedWork W2018765283 @default.
- W2154084135 hasRelatedWork W2031035846 @default.
- W2154084135 hasRelatedWork W2035125534 @default.
- W2154084135 hasRelatedWork W2036170644 @default.
- W2154084135 hasRelatedWork W2049791629 @default.
- W2154084135 hasRelatedWork W2050890843 @default.
- W2154084135 hasRelatedWork W2058252905 @default.
- W2154084135 hasRelatedWork W2095091118 @default.
- W2154084135 hasRelatedWork W2129771745 @default.
- W2154084135 hasRelatedWork W2139983966 @default.
- W2154084135 hasRelatedWork W2141003416 @default.
- W2154084135 hasRelatedWork W2160741225 @default.
- W2154084135 hasRelatedWork W2443135943 @default.
- W2154084135 hasVolume "136" @default.
- W2154084135 isParatext "false" @default.
- W2154084135 isRetracted "false" @default.
- W2154084135 magId "2154084135" @default.
- W2154084135 workType "article" @default.