Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154086732> ?p ?o ?g. }
- W2154086732 endingPage "123" @default.
- W2154086732 startingPage "112" @default.
- W2154086732 abstract "Conditional deletion of Pten (phosphatase and tensin homolog on chromosome ten) in differentiated cortical and hippocampal neurons in the mouse results in seizures, macrocephaly, social interaction deficits and anxiety, reminiscent of human autism spectrum disorder. Here we extended our previous examination of these mice using electroencephalogram/electromyogram (EEG/EMG) monitoring and found age-related increases in spontaneous seizures, which were correlated with cellular dispersion in the hippocampal dentate gyrus. Increased spontaneous locomotor activity in the open field on the first and the second day of a 3-day continuous study suggested heightened anxiety in Pten mutant mice. In contrast, the mutants exhibited decreased wheel running activity, which may reflect reduced adaptability to a novel environment. Synchronization to the light–dark cycle was normal, but for up to 28 days under constant darkness, the Pten mutants maintained a significantly lengthened and remarkably constant free-running period of almost exactly 24 h. This result implies the involvement of Pten in the maintenance of circadian rhythms, which we interpret as being due to an effect on the phosphatidylinositol 3-kinase (PI3K) signaling cascade." @default.
- W2154086732 created "2016-06-24" @default.
- W2154086732 creator A5005276553 @default.
- W2154086732 creator A5007980266 @default.
- W2154086732 creator A5009113588 @default.
- W2154086732 creator A5028755949 @default.
- W2154086732 creator A5060160135 @default.
- W2154086732 creator A5063368083 @default.
- W2154086732 date "2007-09-01" @default.
- W2154086732 modified "2023-10-16" @default.
- W2154086732 title "A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice" @default.
- W2154086732 cites W1499352093 @default.
- W2154086732 cites W1541267199 @default.
- W2154086732 cites W1555898088 @default.
- W2154086732 cites W1557470610 @default.
- W2154086732 cites W1645461202 @default.
- W2154086732 cites W1744822607 @default.
- W2154086732 cites W1862157881 @default.
- W2154086732 cites W1964475851 @default.
- W2154086732 cites W1966481181 @default.
- W2154086732 cites W1967530458 @default.
- W2154086732 cites W1971135095 @default.
- W2154086732 cites W1984944464 @default.
- W2154086732 cites W1992493108 @default.
- W2154086732 cites W1997364930 @default.
- W2154086732 cites W1998038367 @default.
- W2154086732 cites W2015774470 @default.
- W2154086732 cites W2016411894 @default.
- W2154086732 cites W2021193054 @default.
- W2154086732 cites W2021470662 @default.
- W2154086732 cites W2025319925 @default.
- W2154086732 cites W2025839803 @default.
- W2154086732 cites W2030828521 @default.
- W2154086732 cites W2042968249 @default.
- W2154086732 cites W2044391276 @default.
- W2154086732 cites W2048211404 @default.
- W2154086732 cites W2054303452 @default.
- W2154086732 cites W2057308155 @default.
- W2154086732 cites W2058344326 @default.
- W2154086732 cites W2061491996 @default.
- W2154086732 cites W2068427129 @default.
- W2154086732 cites W2072154498 @default.
- W2154086732 cites W2074414345 @default.
- W2154086732 cites W2078086032 @default.
- W2154086732 cites W2086322201 @default.
- W2154086732 cites W2088188719 @default.
- W2154086732 cites W2091028828 @default.
- W2154086732 cites W2091568968 @default.
- W2154086732 cites W2094808217 @default.
- W2154086732 cites W2095124462 @default.
- W2154086732 cites W2102837197 @default.
- W2154086732 cites W2112068085 @default.
- W2154086732 cites W2113136223 @default.
- W2154086732 cites W2115600833 @default.
- W2154086732 cites W2120745993 @default.
- W2154086732 cites W2122925068 @default.
- W2154086732 cites W2123018477 @default.
- W2154086732 cites W2123843070 @default.
- W2154086732 cites W2125300231 @default.
- W2154086732 cites W2133877762 @default.
- W2154086732 cites W2143739956 @default.
- W2154086732 cites W2144540644 @default.
- W2154086732 cites W2154263364 @default.
- W2154086732 cites W2161490965 @default.
- W2154086732 cites W2162128184 @default.
- W2154086732 cites W2165892338 @default.
- W2154086732 cites W2167139902 @default.
- W2154086732 cites W2168013774 @default.
- W2154086732 cites W2170078281 @default.
- W2154086732 cites W4323238142 @default.
- W2154086732 doi "https://doi.org/10.1016/j.brainres.2007.06.074" @default.
- W2154086732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17706614" @default.
- W2154086732 hasPublicationYear "2007" @default.
- W2154086732 type Work @default.
- W2154086732 sameAs 2154086732 @default.
- W2154086732 citedByCount "72" @default.
- W2154086732 countsByYear W21540867322012 @default.
- W2154086732 countsByYear W21540867322014 @default.
- W2154086732 countsByYear W21540867322015 @default.
- W2154086732 countsByYear W21540867322016 @default.
- W2154086732 countsByYear W21540867322017 @default.
- W2154086732 countsByYear W21540867322018 @default.
- W2154086732 countsByYear W21540867322019 @default.
- W2154086732 countsByYear W21540867322020 @default.
- W2154086732 countsByYear W21540867322021 @default.
- W2154086732 countsByYear W21540867322022 @default.
- W2154086732 countsByYear W21540867322023 @default.
- W2154086732 crossrefType "journal-article" @default.
- W2154086732 hasAuthorship W2154086732A5005276553 @default.
- W2154086732 hasAuthorship W2154086732A5007980266 @default.
- W2154086732 hasAuthorship W2154086732A5009113588 @default.
- W2154086732 hasAuthorship W2154086732A5028755949 @default.
- W2154086732 hasAuthorship W2154086732A5060160135 @default.
- W2154086732 hasAuthorship W2154086732A5063368083 @default.
- W2154086732 hasConcept C118552586 @default.
- W2154086732 hasConcept C121446783 @default.
- W2154086732 hasConcept C126322002 @default.
- W2154086732 hasConcept C134018914 @default.