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- W2154090009 abstract "To study the relationship between homologous recombination and DNA replication in Escherichia coli, we monitored the behavior of phage lambda chromosomes, repressed or not for lambda gene activities. Recombination in our system is stimulated both by DNA replication and by experimentally introduced double-strand ends, supporting the idea that DNA replication generates occasional double-strand ends. We report that the RecBC recombinational pathway of E. coli uses double-strand ends to prime DNA synthesis, implying a circular relationship between DNA replication and recombination and suggesting that the primary role of recombination is in the repair of disintegrated replication forks arising during vegetative reproduction." @default.
- W2154090009 created "2016-06-24" @default.
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- W2154090009 date "1999-02-01" @default.
- W2154090009 modified "2023-10-06" @default.
- W2154090009 title "Double-strand end repair via the RecBC pathway in Escherichia coli primes DNA replication" @default.
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- W2154090009 doi "https://doi.org/10.1101/gad.13.3.345" @default.
- W2154090009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316432" @default.
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