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• W2154091509 abstract "Proton pump inhibitors have become the preferred therapy for gastro-oesophageal reflux disease and other acid-related disorders. Without clear-cut clinical data to help clinicians differentiate the impact of the five currently available proton pump inhibitors on early symptom relief and health-related quality of life, we can explore potentially relevant differences in pharmacodynamic profiles of these proton pump inhibitors. In general, rabeprazole 10 and 20 mg achieve greater gastric pH >4 and >3 holding times and area under gastric pH–time curves on day 1 of treatment compared with other proton pump inhibitors. Superiority in day 1 pharmacodynamic measures corroborates fast antisecretory onset, and supports the premise that rabeprazole will be especially suitable for on-demand use. In particular, comparisons with omeprazole and esomeprazole suggest better day 1 nocturnal acid control with rabeprazole." @default.
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• W2154091509 date "2006-07-01" @default.
• W2154091509 modified "2023-10-16" @default.
• W2154091509 title "Review article: comparative pharmacodynamic review of rabeprazole - focus on day 1 data" @default.
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• W2154091509 doi "https://doi.org/10.1111/j.1746-6342.2006.00062.x" @default.
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