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- W2154092435 abstract "Naive antiviral CD8+ T cells are activated in the draining LN (DLN) by dendritic cells (DCs) presenting viral antigens. However, many viruses infect LN macrophages, which participate in initiation of innate immunity and B cell activation. To better understand how and why T cells select infected DCs rather than macrophages, we performed intravital microscopy and ex vivo analyses after infecting mice with vaccinia virus (VV), a large DNA virus that infects both LN macrophages and DCs. Although CD8+ T cells interact with both infected macrophages and DCs in the LN peripheral interfollicular region (PIR), DCs generate more frequent and stable interactions with T cells. VV infection induces rapid release of CCR5-binding chemokines in the LN, and administration of chemokine-neutralizing antibodies diminishes T cell activation by increasing T cell localization to macrophages in the macrophage-rich region (MRR) at the expense of PIR DCs. Similarly, DC ablation increases both T cell localization to the MRR and the duration of T cell–macrophage contacts, resulting in suboptimal T cell activation. Thus, virus-induced chemokines in DLNs enable antiviral CD8+ T cells to distinguish DCs from macrophages to optimize T cell priming." @default.
- W2154092435 created "2016-06-24" @default.
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- W2154092435 date "2011-10-31" @default.
- W2154092435 modified "2023-10-12" @default.
- W2154092435 title "Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells" @default.
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- W2154092435 doi "https://doi.org/10.1084/jem.20102545" @default.
- W2154092435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3256957" @default.
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