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• W2154092962 abstract "The aim of the present study was to determine the behavioural effects of the selective dopamine D1 receptor agonist, SKF 38393, and of the selective dopamine D2/D3 receptor agonist, quinpirole, on the feeding performance of food-deprived rats in a model of food-preference behaviour. The animals were familiarised with a choice between a high-palatability, high-fat, high-sugar food (chocolate biscuits/cookies) and their regular maintenance diet. Following administration of either SKF 38393 (1.0–10.0 mg/kg, s.c.) or quinpirole (0.03–0.3 mg/kg, s.c.), the animals were observed throughout a 15-min test period, and their feeding behaviour was carefully monitored. Other behavioural categories were also observed. The resulting data were subject to a microstructural analysis to determine the loci of the behavioural effects. The results indicated that SKF 38393 and quinpirole had contrasting effects on the preference for the high-palatability chocolate food. SKF 38393 enhanced the preference, whereas quinpirole eliminated it. These data reinforce the view that forebrain dopamine mechanisms are closely involved in responses to high-palatability energy-dense food constituents, including chocolate. The data also indicate that pharmacological characterization is important, such that dopamine receptor subtypes appear to mediate contrasting effects on food preference for a high-fat, high-sugar food. Hence, brain dopamine appears to be involved in potentially complex ways in determining food preferences, and this may carry implications in the growing evidence for a link between brain dopamine and human obesity." @default.
• W2154092962 created "2016-06-24" @default.
• W2154092962 creator A5020739932 @default.
• W2154092962 creator A5053459025 @default.
• W2154092962 date "2006-06-01" @default.
• W2154092962 modified "2023-09-23" @default.
• W2154092962 title "Dopaminergic control of food choice: Contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat" @default.
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• W2154092962 doi "https://doi.org/10.1016/j.neuropharm.2006.01.006" @default.
• W2154092962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16549074" @default.
• W2154092962 hasPublicationYear "2006" @default.
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