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• W2154111336 abstract "BACKGROUND: The different macromolecules as secreted by macrophages (Mφ) in the pelvic environment are believed to enhance the growth of endometriosis. However, the possible mediator that stimulates Mφ for the production of different growth factors is not well described. Therefore, we investigated the possible production of hepatocyte growth factor (HGF) by the basal and lipopolysaccharide (LPS)-stimulated Mφ derived from women with or without endometriosis. METHODS: Using primary culture and 4-well chamber slides, adherent Mφ immunoreactive to CD68 were isolated from the peritoneal fluid (PF) of 20 infertile women with endometriosis and 12 women without endometriosis. The proliferation of basal and LPS-treated Mφ was investigated by the dimethylthiazole tetrazolioum bromide (MTT) assay. The production of HGF in the culture media of basal and LPS-stimulated Mφ was examined by enyme-linked immunosorbent assay. The expression of mRNA for HGF and its receptor, c-Met, in the Mφ was investigated by RT–PCR. The effect of HGF on the growth of endometrial cells and Mφ was analysed by bromodeoxyuridine (BrdU) incorporation. RESULTS: A >100% increase in the proliferation of peritoneal Mφ derived from women with endometriosis, and particularly of those harbouring dominant red lesions, was observed after treatment with LPS (P<0.05). A 4- and 3-fold increase in the production of HGF was observed by the LPS-treated Mφ derived from women with stage I–II endometriosis and stage III–IV endometriosis, respectively, when compared with non-LPS-treated Mφ (P<0.001). At the transcriptional level, we found a 5-fold increase in HGF mRNA expression in LPS-treated Mφ versus basal Mφ in women with endometriosis (P<0.001). The BrdU incorporation study indicates that 10–100 ng/ml of HGF enhanced the growth of endometrial epithelial cells, stroma and Mφ (∼50% increase) derived from women with endometriosis (all P<0.05). CONCLUSION: LPS could be an inflammatory mediator of macrophage stimulation in the pelvic microenvironment. Besides mesenchymal cells, HGF is also produced by peritoneal Mφ and is possibly involved in the growth of endometriosis." @default.
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• W2154111336 date "2005-01-01" @default.
• W2154111336 modified "2023-10-17" @default.
• W2154111336 title "Regulation of hepatocyte growth factor by basal and stimulated macrophages in women with endometriosis" @default.
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• W2154111336 doi "https://doi.org/10.1093/humrep/deh525" @default.
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