FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154114549> ?p ?o ?g. }

• W2154114549 endingPage "824" @default.
• W2154114549 startingPage "819" @default.
• W2154114549 abstract "For patients receiving high-dose chemotherapy, a 5-hydroxytryptamine 3 receptor antagonist combined with dexamethasone is a standard antiemetic therapy. Despite this prophylactic anti-emetic treatment, many patients still suffer from uncontrollable emesis. In this study, we retrospectively evaluated the antiemetic effectiveness and safety of aprepitant (a neurokinin-1 receptor antagonist) in addition to 5-HT3 antagonist in Japanese patients with hematologic malignancy receiving high-dose chemotherapy prior to autologous peripheral blood stem cell transplantation (auto-PBSCT). Twenty-six patients received aprepitant and granisetron (the aprepitant group), whereas, 22 patients received granisetron alone (the control group). All patients received 3 mg of granisetron intravenously 30 min before chemotherapy administration. Patients in the aprepitant group additionally received 125 mg of aprepitant 60–90 min before administration of the first moderately to highly emetogenic chemotherapy. On the next day or thereafter, 80 mg of aprepitant was administered in the morning until the last administration of moderately to highly emetogenic anticancer drugs. The percentage of patients who achieved complete response (CR), defined as no emesis with only grade 1–2 nausea, in the aprepitant group was significantly higher than that in the control group (42% vs. 5%, p=0.003). Logistic regression analysis showed that non-prophylactic use of aprepitant was significantly associated with non-CR. The frequencies of adverse drug events (ADEs) were not significantly different between two groups. In conclusion, the results of this study suggest that the addition of aprepitant to granisetron can improve the antiemetic effect without increasing ADEs in patients receiving high-dose chemotherapy prior to auto-PBSCT." @default.
• W2154114549 created "2016-06-24" @default.
• W2154114549 creator A5001924975 @default.
• W2154114549 creator A5005324760 @default.
• W2154114549 creator A5009874981 @default.
• W2154114549 creator A5020162205 @default.
• W2154114549 creator A5023687497 @default.
• W2154114549 creator A5026278665 @default.
• W2154114549 creator A5028379115 @default.
• W2154114549 creator A5039054605 @default.
• W2154114549 creator A5041455800 @default.
• W2154114549 creator A5053130937 @default.
• W2154114549 creator A5060126327 @default.
• W2154114549 creator A5066039877 @default.
• W2154114549 creator A5070706221 @default.
• W2154114549 creator A5079275805 @default.
• W2154114549 creator A5084708258 @default.
• W2154114549 creator A5091093961 @default.
• W2154114549 date "2013-01-01" @default.
• W2154114549 modified "2023-09-23" @default.
• W2154114549 title "Effectiveness and Safety of Antiemetic Aprepitant in Japanese Patients Receiving High-Dose Chemotherapy Prior to Autologous Hematopoietic Stem Cell Transplantation" @default.
• W2154114549 cites W1993434718 @default.
• W2154114549 cites W1994776603 @default.
• W2154114549 cites W2033769280 @default.
• W2154114549 cites W2092980247 @default.
• W2154114549 cites W2283064218 @default.
• W2154114549 doi "https://doi.org/10.1248/bpb.b12-01012" @default.
• W2154114549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23649338" @default.
• W2154114549 hasPublicationYear "2013" @default.
• W2154114549 type Work @default.
• W2154114549 sameAs 2154114549 @default.
• W2154114549 citedByCount "11" @default.
• W2154114549 countsByYear W21541145492014 @default.
• W2154114549 countsByYear W21541145492016 @default.
• W2154114549 countsByYear W21541145492017 @default.
• W2154114549 countsByYear W21541145492018 @default.
• W2154114549 countsByYear W21541145492019 @default.
• W2154114549 countsByYear W21541145492020 @default.
• W2154114549 countsByYear W21541145492021 @default.
• W2154114549 countsByYear W21541145492022 @default.
• W2154114549 crossrefType "journal-article" @default.
• W2154114549 hasAuthorship W2154114549A5001924975 @default.
• W2154114549 hasAuthorship W2154114549A5005324760 @default.
• W2154114549 hasAuthorship W2154114549A5009874981 @default.
• W2154114549 hasAuthorship W2154114549A5020162205 @default.
• W2154114549 hasAuthorship W2154114549A5023687497 @default.
• W2154114549 hasAuthorship W2154114549A5026278665 @default.
• W2154114549 hasAuthorship W2154114549A5028379115 @default.
• W2154114549 hasAuthorship W2154114549A5039054605 @default.
• W2154114549 hasAuthorship W2154114549A5041455800 @default.
• W2154114549 hasAuthorship W2154114549A5053130937 @default.
• W2154114549 hasAuthorship W2154114549A5060126327 @default.
• W2154114549 hasAuthorship W2154114549A5066039877 @default.
• W2154114549 hasAuthorship W2154114549A5070706221 @default.
• W2154114549 hasAuthorship W2154114549A5079275805 @default.
• W2154114549 hasAuthorship W2154114549A5084708258 @default.
• W2154114549 hasAuthorship W2154114549A5091093961 @default.
• W2154114549 hasBestOaLocation W21541145491 @default.
• W2154114549 hasConcept C126322002 @default.
• W2154114549 hasConcept C197934379 @default.
• W2154114549 hasConcept C2776694085 @default.
• W2154114549 hasConcept C2777452722 @default.
• W2154114549 hasConcept C2780574406 @default.
• W2154114549 hasConcept C2780580376 @default.
• W2154114549 hasConcept C2780852908 @default.
• W2154114549 hasConcept C2780884295 @default.
• W2154114549 hasConcept C2911091166 @default.
• W2154114549 hasConcept C42219234 @default.
• W2154114549 hasConcept C71924100 @default.
• W2154114549 hasConcept C98274493 @default.
• W2154114549 hasConceptScore W2154114549C126322002 @default.
• W2154114549 hasConceptScore W2154114549C197934379 @default.
• W2154114549 hasConceptScore W2154114549C2776694085 @default.
• W2154114549 hasConceptScore W2154114549C2777452722 @default.
• W2154114549 hasConceptScore W2154114549C2780574406 @default.
• W2154114549 hasConceptScore W2154114549C2780580376 @default.
• W2154114549 hasConceptScore W2154114549C2780852908 @default.
• W2154114549 hasConceptScore W2154114549C2780884295 @default.
• W2154114549 hasConceptScore W2154114549C2911091166 @default.
• W2154114549 hasConceptScore W2154114549C42219234 @default.
• W2154114549 hasConceptScore W2154114549C71924100 @default.
• W2154114549 hasConceptScore W2154114549C98274493 @default.
• W2154114549 hasIssue "5" @default.
• W2154114549 hasLocation W21541145491 @default.
• W2154114549 hasLocation W21541145492 @default.
• W2154114549 hasOpenAccess W2154114549 @default.
• W2154114549 hasPrimaryLocation W21541145491 @default.
• W2154114549 hasRelatedWork W2007722967 @default.
• W2154114549 hasRelatedWork W2022077452 @default.
• W2154114549 hasRelatedWork W2034199439 @default.
• W2154114549 hasRelatedWork W2074431992 @default.
• W2154114549 hasRelatedWork W2099365808 @default.
• W2154114549 hasRelatedWork W2175009382 @default.
• W2154114549 hasRelatedWork W2307524438 @default.
• W2154114549 hasRelatedWork W2348573567 @default.
• W2154114549 hasRelatedWork W2351639907 @default.
• W2154114549 hasRelatedWork W2578647673 @default.
• W2154114549 hasVolume "36" @default.

• next