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- W2154125268 abstract "A new direct and noninvasive methodology based on transient absorption spectroscopy has been developed to probe the feasibility of drug-drug interactions within a common protein binding site. The simultaneous presence of (R)-cinacalcet (CIN) and (S)-propranolol (PPN) within human or bovine α1-acid glycoproteins (AAGs) is revealed by detection of (3)CIN* as the only transient species after laser flash photolysis of CIN/PPN/AAG mixtures at 308 nm. This is the result of triplet-triplet energy transfer from (3)PPN* to CIN, which requires close contact between the two drugs within the same biological compartment. Similar results are obtained with nabumetone and CIN as donor/acceptor partners. This new methodology can, in principle, be extended to a variety of drug/drug/biomolecule combinations." @default.
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- W2154125268 date "2013-04-25" @default.
- W2154125268 modified "2023-10-02" @default.
- W2154125268 title "Drug–Drug Interactions within Protein Cavities Probed by Triplet–Triplet Energy Transfer" @default.
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- W2154125268 doi "https://doi.org/10.1021/jz400640s" @default.
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