FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154133668> ?p ?o ?g. }

• W2154133668 endingPage "681" @default.
• W2154133668 startingPage "675" @default.
• W2154133668 abstract "Medical intervention plays a key role in the treatment of postmenopausal osteoporosis and patients' adherence to therapy is essential for optimal clinical outcomes. While adherence in RCTs is usually around 70-90%, a previous study showed that in clinical practice only 27.8% and 46.5% of the women on oral daily vs. weekly alendronate were still on treatment after 12 months. Data on adherence to teriparatide (TPTD) treatment of severe postmenopausal osteoporosis are available from only few countries. This study assessed adherence and persistence with TPTD in Germany.A sample of 50 women with severe postmenopausal osteoporosis treated with TPTD in accordance to the German osteoporosis guidelines was included. Treatment was initiated 12-24 months before recruitment. Patient self report was assessed using a validated questionnaire. In addition medication possession ratio (MPR) was calculated by counting prescription refills, and therefore all physicians who were treating the patients for any disease were contacted. Patients were classified adherent at 12 months of therapy if self-reported adherence and an MPR of > or =80% were achieved. Persistence was calculated in months and analysed with a Kaplan-Meier estimate.Apart from a significantly lower age at menopause in the adherent group (46.1 vs. 50.0; p < 0.006) there were no significant differences in baseline demographics between adherent and non-adherent patients. After 12 months, 80% of the patients treated with TPTD were adherent, while 20% were non-adherent. A significant correlation with treatment adherence was found for self-reported medication tolerability (p < 0.001). Furthermore 79% of patients were persistent after 12 months.These results indicate that more patients seem to be adherent and persistent with TPTD than with oral treatments of postmenopausal osteoporosis. As these patients suffered from severe osteoporosis and sustained several fragility fractures, the generalisability of our retrospective study analysing a small sample is limited. The major factor that reduced adherence and persistence was tolerability. These findings are of practical relevance as numerous studies on antiresorptive therapies have shown that high adherence and persistence were needed to ensure an optimal therapeutic outcome." @default.
• W2154133668 created "2016-06-24" @default.
• W2154133668 creator A5010572524 @default.
• W2154133668 creator A5016290825 @default.
• W2154133668 creator A5026364343 @default.
• W2154133668 creator A5028450771 @default.
• W2154133668 creator A5064097757 @default.
• W2154133668 creator A5070338465 @default.
• W2154133668 creator A5090998544 @default.
• W2154133668 date "2010-01-15" @default.
• W2154133668 modified "2023-10-05" @default.
• W2154133668 title "Adherence and persistence in patients with severe osteoporosis treated with teriparatide" @default.
• W2154133668 cites W1984037815 @default.
• W2154133668 cites W1988202089 @default.
• W2154133668 cites W1996926816 @default.
• W2154133668 cites W1998033364 @default.
• W2154133668 cites W2013058303 @default.
• W2154133668 cites W2022343568 @default.
• W2154133668 cites W2031756259 @default.
• W2154133668 cites W2032093049 @default.
• W2154133668 cites W2048541373 @default.
• W2154133668 cites W2062496249 @default.
• W2154133668 cites W2070531118 @default.
• W2154133668 cites W2074724534 @default.
• W2154133668 cites W2075065709 @default.
• W2154133668 cites W2097310012 @default.
• W2154133668 cites W2100079372 @default.
• W2154133668 cites W2108526974 @default.
• W2154133668 cites W2126194653 @default.
• W2154133668 cites W2139062201 @default.
• W2154133668 cites W2140516514 @default.
• W2154133668 cites W2141336118 @default.
• W2154133668 cites W2147247664 @default.
• W2154133668 cites W2314978377 @default.
• W2154133668 cites W2335178464 @default.
• W2154133668 cites W2410662655 @default.
• W2154133668 doi "https://doi.org/10.1185/03007990903538409" @default.
• W2154133668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20078188" @default.
• W2154133668 hasPublicationYear "2010" @default.
• W2154133668 type Work @default.
• W2154133668 sameAs 2154133668 @default.
• W2154133668 citedByCount "33" @default.
• W2154133668 countsByYear W21541336682012 @default.
• W2154133668 countsByYear W21541336682013 @default.
• W2154133668 countsByYear W21541336682014 @default.
• W2154133668 countsByYear W21541336682015 @default.
• W2154133668 countsByYear W21541336682016 @default.
• W2154133668 countsByYear W21541336682017 @default.
• W2154133668 countsByYear W21541336682018 @default.
• W2154133668 countsByYear W21541336682019 @default.
• W2154133668 countsByYear W21541336682021 @default.
• W2154133668 countsByYear W21541336682022 @default.
• W2154133668 countsByYear W21541336682023 @default.
• W2154133668 crossrefType "journal-article" @default.
• W2154133668 hasAuthorship W2154133668A5010572524 @default.
• W2154133668 hasAuthorship W2154133668A5016290825 @default.
• W2154133668 hasAuthorship W2154133668A5026364343 @default.
• W2154133668 hasAuthorship W2154133668A5028450771 @default.
• W2154133668 hasAuthorship W2154133668A5064097757 @default.
• W2154133668 hasAuthorship W2154133668A5070338465 @default.
• W2154133668 hasAuthorship W2154133668A5090998544 @default.
• W2154133668 hasConcept C126322002 @default.
• W2154133668 hasConcept C127413603 @default.
• W2154133668 hasConcept C1862650 @default.
• W2154133668 hasConcept C187320778 @default.
• W2154133668 hasConcept C197934379 @default.
• W2154133668 hasConcept C2426938 @default.
• W2154133668 hasConcept C2776541429 @default.
• W2154133668 hasConcept C2776886416 @default.
• W2154133668 hasConcept C2777308945 @default.
• W2154133668 hasConcept C2778375690 @default.
• W2154133668 hasConcept C2778562196 @default.
• W2154133668 hasConcept C2781009140 @default.
• W2154133668 hasConcept C71924100 @default.
• W2154133668 hasConcept C98274493 @default.
• W2154133668 hasConceptScore W2154133668C126322002 @default.
• W2154133668 hasConceptScore W2154133668C127413603 @default.
• W2154133668 hasConceptScore W2154133668C1862650 @default.
• W2154133668 hasConceptScore W2154133668C187320778 @default.
• W2154133668 hasConceptScore W2154133668C197934379 @default.
• W2154133668 hasConceptScore W2154133668C2426938 @default.
• W2154133668 hasConceptScore W2154133668C2776541429 @default.
• W2154133668 hasConceptScore W2154133668C2776886416 @default.
• W2154133668 hasConceptScore W2154133668C2777308945 @default.
• W2154133668 hasConceptScore W2154133668C2778375690 @default.
• W2154133668 hasConceptScore W2154133668C2778562196 @default.
• W2154133668 hasConceptScore W2154133668C2781009140 @default.
• W2154133668 hasConceptScore W2154133668C71924100 @default.
• W2154133668 hasConceptScore W2154133668C98274493 @default.
• W2154133668 hasIssue "3" @default.
• W2154133668 hasLocation W21541336681 @default.
• W2154133668 hasLocation W21541336682 @default.
• W2154133668 hasOpenAccess W2154133668 @default.
• W2154133668 hasPrimaryLocation W21541336681 @default.
• W2154133668 hasRelatedWork W1949389001 @default.
• W2154133668 hasRelatedWork W2012670471 @default.
• W2154133668 hasRelatedWork W2030420098 @default.
• W2154133668 hasRelatedWork W2145289562 @default.

• next