FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154142736> ?p ?o ?g. }

• W2154142736 endingPage "3899" @default.
• W2154142736 startingPage "3894" @default.
• W2154142736 abstract "SAR studies for N-aryl-N′-benzyl urea class of TRPV1 antagonists have been extended to cover α-benzyl alkylation. Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Further structural manipulations that included replacement of isoquinoline core with indazole and isolation of single enantiomer led to TRPV1 antagonists like (R)-16a with superior pharmacokinetic properties and greater potency in animal model of inflammatory pain." @default.
• W2154142736 created "2016-06-24" @default.
• W2154142736 creator A5006827947 @default.
• W2154142736 creator A5009641305 @default.
• W2154142736 creator A5013674131 @default.
• W2154142736 creator A5016128511 @default.
• W2154142736 creator A5025944882 @default.
• W2154142736 creator A5026852803 @default.
• W2154142736 creator A5028708112 @default.
• W2154142736 creator A5040757035 @default.
• W2154142736 creator A5050177535 @default.
• W2154142736 creator A5051190629 @default.
• W2154142736 creator A5058286194 @default.
• W2154142736 creator A5067058550 @default.
• W2154142736 creator A5071494436 @default.
• W2154142736 creator A5073001403 @default.
• W2154142736 creator A5076608995 @default.
• W2154142736 creator A5078652224 @default.
• W2154142736 creator A5080117947 @default.
• W2154142736 date "2007-07-01" @default.
• W2154142736 modified "2023-10-15" @default.
• W2154142736 title "α-Methylation at benzylic fragment of N-aryl-N′-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model" @default.
• W2154142736 cites W1527988408 @default.
• W2154142736 cites W1984873488 @default.
• W2154142736 cites W1990122447 @default.
• W2154142736 cites W1992107007 @default.
• W2154142736 cites W2018814467 @default.
• W2154142736 cites W2045592577 @default.
• W2154142736 cites W2046859828 @default.
• W2154142736 cites W2054930916 @default.
• W2154142736 cites W2073606727 @default.
• W2154142736 cites W2106753138 @default.
• W2154142736 cites W2117301151 @default.
• W2154142736 cites W2118626190 @default.
• W2154142736 cites W2325466198 @default.
• W2154142736 cites W2950451750 @default.
• W2154142736 cites W2953163308 @default.
• W2154142736 doi "https://doi.org/10.1016/j.bmcl.2007.04.105" @default.
• W2154142736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17507218" @default.
• W2154142736 hasPublicationYear "2007" @default.
• W2154142736 type Work @default.
• W2154142736 sameAs 2154142736 @default.
• W2154142736 citedByCount "26" @default.
• W2154142736 countsByYear W21541427362012 @default.
• W2154142736 countsByYear W21541427362013 @default.
• W2154142736 countsByYear W21541427362014 @default.
• W2154142736 countsByYear W21541427362015 @default.
• W2154142736 countsByYear W21541427362016 @default.
• W2154142736 countsByYear W21541427362018 @default.
• W2154142736 countsByYear W21541427362019 @default.
• W2154142736 countsByYear W21541427362021 @default.
• W2154142736 countsByYear W21541427362022 @default.
• W2154142736 crossrefType "journal-article" @default.
• W2154142736 hasAuthorship W2154142736A5006827947 @default.
• W2154142736 hasAuthorship W2154142736A5009641305 @default.
• W2154142736 hasAuthorship W2154142736A5013674131 @default.
• W2154142736 hasAuthorship W2154142736A5016128511 @default.
• W2154142736 hasAuthorship W2154142736A5025944882 @default.
• W2154142736 hasAuthorship W2154142736A5026852803 @default.
• W2154142736 hasAuthorship W2154142736A5028708112 @default.
• W2154142736 hasAuthorship W2154142736A5040757035 @default.
• W2154142736 hasAuthorship W2154142736A5050177535 @default.
• W2154142736 hasAuthorship W2154142736A5051190629 @default.
• W2154142736 hasAuthorship W2154142736A5058286194 @default.
• W2154142736 hasAuthorship W2154142736A5067058550 @default.
• W2154142736 hasAuthorship W2154142736A5071494436 @default.
• W2154142736 hasAuthorship W2154142736A5073001403 @default.
• W2154142736 hasAuthorship W2154142736A5076608995 @default.
• W2154142736 hasAuthorship W2154142736A5078652224 @default.
• W2154142736 hasAuthorship W2154142736A5080117947 @default.
• W2154142736 hasConcept C112705442 @default.
• W2154142736 hasConcept C150903083 @default.
• W2154142736 hasConcept C155164980 @default.
• W2154142736 hasConcept C160145004 @default.
• W2154142736 hasConcept C161790260 @default.
• W2154142736 hasConcept C164361826 @default.
• W2154142736 hasConcept C170493617 @default.
• W2154142736 hasConcept C178790620 @default.
• W2154142736 hasConcept C185592680 @default.
• W2154142736 hasConcept C207001950 @default.
• W2154142736 hasConcept C2780051329 @default.
• W2154142736 hasConcept C2780263894 @default.
• W2154142736 hasConcept C2780591553 @default.
• W2154142736 hasConcept C2781076698 @default.
• W2154142736 hasConcept C486523 @default.
• W2154142736 hasConcept C55493867 @default.
• W2154142736 hasConcept C71240020 @default.
• W2154142736 hasConcept C71924100 @default.
• W2154142736 hasConcept C86803240 @default.
• W2154142736 hasConcept C98274493 @default.
• W2154142736 hasConceptScore W2154142736C112705442 @default.
• W2154142736 hasConceptScore W2154142736C150903083 @default.
• W2154142736 hasConceptScore W2154142736C155164980 @default.
• W2154142736 hasConceptScore W2154142736C160145004 @default.
• W2154142736 hasConceptScore W2154142736C161790260 @default.
• W2154142736 hasConceptScore W2154142736C164361826 @default.
• W2154142736 hasConceptScore W2154142736C170493617 @default.
• W2154142736 hasConceptScore W2154142736C178790620 @default.

• next