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- W2154155929 abstract "Objective: To explore the effect of Withaferin A on A549 cellular proliferation and apoptosis in non-small cell lung cancer (NSCLC). Materials and Methods: NSCLC cell line A549 was selected to explore the effect of Withaferin A on A549 cellular proliferation, apoptosis and the PI3K/Akt signal pathway capable of regulating tumor biological behavior by assessment of cellular proliferation, cellular apoptotic rates and cellular cycling as well as by immuno-blotting. Results: Withaferin A could inhibit A549 cellular proliferation and the control rate was dosage-dependent (P<0.05), which also increased time-dependently with the same dosage of Withaferin A (P<0.05). The apoptotic indexes in A549 cells treated with 0, 2.5, 5.0, 10.0 and 20.0 <TEX>${mu}mol{cdot}L^{-1}$</TEX> Withaferin A for 48 h were significantly different (P<0.05). In addition, the apoptotic rates of each group in both early and advanced stages were higher than those in 0 <TEX>${mu}mol{cdot}L^{-1}$</TEX> (P<0.05), which were evidently higher after 48 h than those after 24 h (P<0.05). A549 cells treated by Withaferin A for 48 h were markedly lower in Bcl-2 level and obviously higher in Bax and cleaved caspase-3 levels than those treated by 0 <TEX>${mu}mol{cdot}L^{-1}$</TEX> Withaferin A (P<0.05), and there were significant differences among 5, 10 and 20 <TEX>${mu}mol{cdot}L^{-1}$</TEX> Withaferin A (P<0.05). The ratios of A549 cells treated by Withaferin A for 48 h in G0/G1 stage were higher than those in 0 <TEX>${mu}mol{cdot}L^{-1}$</TEX>, while those in S and G2/M stages were obviously lower than those in G2/M stage, and there were significant differences in 5.0, 10.0 and 20.0 <TEX>${mu}mol{cdot}L^{-1}$</TEX> Withaferin A (P<0.05). Additionally, p-Akt/Akt values were in reverse association with dosage, and the differences were significant (P<0.05). Conclusion: Withaferin A can inhibit the proliferation and apoptosis of A549 cells by suppressing activation of the PI3K/Akt pathways." @default.
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- W2154155929 date "2014-02-28" @default.
- W2154155929 modified "2023-10-11" @default.
- W2154155929 title "Effect of Withaferin A on A549 Cellular Proliferation and Apoptosis in Non-small Cell Lung Cancer" @default.
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- W2154155929 doi "https://doi.org/10.7314/apjcp.2014.15.4.1711" @default.
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