FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154160889> ?p ?o ?g. }

• W2154160889 endingPage "721" @default.
• W2154160889 startingPage "714" @default.
• W2154160889 abstract "BackgroundSunitinib is a standard of care for metastatic renal cell carcinoma (mRCC). Hypothyroidism is frequently observed under sunitinib therapy. This study was conducted to prospectively determine the correlation between thyroid function and progression-free survival (PFS) in this population.Patients and methodsOne hundred and eleven mRCC patients treated with sunitinib were evaluated for serum thyroid-stimulating hormone (TSH) and T4 levels before treatment and every 6 weeks during treatment. Survival was analysed according to a landmark method with a cut-off of 6 months, excluding early progressive or early-censored patients.ResultsOut of the 102 patients with normal baseline thyroid function, 53% developed thyroid dysfunction, including 95% hypothyroidisms out of which 90.9% received L-thyroxine replacement. Median time to TSH alteration was 5.4 months. Median PFS was 11.7 months for the entire population. Median PFS was not different between the groups with abnormal or normal thyroid function after 6 months of treatment (18.9 and 15.9 months, respectively, log-rank P = 0.94, hazard ratio = 1.02, 95% confidence interval = 0.54–1.93). There was no difference even after adjustment for Memorial Sloan-Kettering Cancer Centre classification and therapy line.ConclusionsAbnormal thyroid function with hormonal substitution did not increase survival in our population, independent of initial prognosis and previous treatments. Larger comparative studies are deserved to validate these conclusions." @default.
• W2154160889 created "2016-06-24" @default.
• W2154160889 creator A5009364522 @default.
• W2154160889 creator A5011899504 @default.
• W2154160889 creator A5015693618 @default.
• W2154160889 creator A5021061571 @default.
• W2154160889 creator A5032770215 @default.
• W2154160889 creator A5038321597 @default.
• W2154160889 creator A5043716462 @default.
• W2154160889 creator A5046717802 @default.
• W2154160889 creator A5051451059 @default.
• W2154160889 creator A5053950718 @default.
• W2154160889 creator A5061348202 @default.
• W2154160889 creator A5067036952 @default.
• W2154160889 date "2012-03-01" @default.
• W2154160889 modified "2023-10-18" @default.
• W2154160889 title "Could thyroid dysfunction influence outcome in sunitinib-treated metastatic renal cell carcinoma?" @default.
• W2154160889 cites W1933440621 @default.
• W2154160889 cites W1969504294 @default.
• W2154160889 cites W1986032822 @default.
• W2154160889 cites W1996741325 @default.
• W2154160889 cites W2008122005 @default.
• W2154160889 cites W2022306625 @default.
• W2154160889 cites W2031852029 @default.
• W2154160889 cites W2036114194 @default.
• W2154160889 cites W2048404979 @default.
• W2154160889 cites W2051963942 @default.
• W2154160889 cites W2067216473 @default.
• W2154160889 cites W2079272324 @default.
• W2154160889 cites W2097279006 @default.
• W2154160889 cites W2097535250 @default.
• W2154160889 cites W2099088585 @default.
• W2154160889 cites W2105677187 @default.
• W2154160889 cites W2107116656 @default.
• W2154160889 cites W2112467833 @default.
• W2154160889 cites W2132272301 @default.
• W2154160889 cites W2139511378 @default.
• W2154160889 cites W2143813821 @default.
• W2154160889 cites W2149267995 @default.
• W2154160889 cites W2149456801 @default.
• W2154160889 cites W2154117685 @default.
• W2154160889 cites W2157032670 @default.
• W2154160889 cites W2163814095 @default.
• W2154160889 cites W2336865510 @default.
• W2154160889 cites W28734780 @default.
• W2154160889 cites W4239330499 @default.
• W2154160889 doi "https://doi.org/10.1093/annonc/mdr275" @default.
• W2154160889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21653681" @default.
• W2154160889 hasPublicationYear "2012" @default.
• W2154160889 type Work @default.
• W2154160889 sameAs 2154160889 @default.
• W2154160889 citedByCount "54" @default.
• W2154160889 countsByYear W21541608892012 @default.
• W2154160889 countsByYear W21541608892013 @default.
• W2154160889 countsByYear W21541608892014 @default.
• W2154160889 countsByYear W21541608892015 @default.
• W2154160889 countsByYear W21541608892016 @default.
• W2154160889 countsByYear W21541608892017 @default.
• W2154160889 countsByYear W21541608892018 @default.
• W2154160889 countsByYear W21541608892019 @default.
• W2154160889 countsByYear W21541608892020 @default.
• W2154160889 countsByYear W21541608892021 @default.
• W2154160889 countsByYear W21541608892022 @default.
• W2154160889 countsByYear W21541608892023 @default.
• W2154160889 crossrefType "journal-article" @default.
• W2154160889 hasAuthorship W2154160889A5009364522 @default.
• W2154160889 hasAuthorship W2154160889A5011899504 @default.
• W2154160889 hasAuthorship W2154160889A5015693618 @default.
• W2154160889 hasAuthorship W2154160889A5021061571 @default.
• W2154160889 hasAuthorship W2154160889A5032770215 @default.
• W2154160889 hasAuthorship W2154160889A5038321597 @default.
• W2154160889 hasAuthorship W2154160889A5043716462 @default.
• W2154160889 hasAuthorship W2154160889A5046717802 @default.
• W2154160889 hasAuthorship W2154160889A5051451059 @default.
• W2154160889 hasAuthorship W2154160889A5053950718 @default.
• W2154160889 hasAuthorship W2154160889A5061348202 @default.
• W2154160889 hasAuthorship W2154160889A5067036952 @default.
• W2154160889 hasBestOaLocation W21541608891 @default.
• W2154160889 hasConcept C126322002 @default.
• W2154160889 hasConcept C126894567 @default.
• W2154160889 hasConcept C141071460 @default.
• W2154160889 hasConcept C143998085 @default.
• W2154160889 hasConcept C207103383 @default.
• W2154160889 hasConcept C2777472916 @default.
• W2154160889 hasConcept C2778840127 @default.
• W2154160889 hasConcept C2779490328 @default.
• W2154160889 hasConcept C2908647359 @default.
• W2154160889 hasConcept C2993291352 @default.
• W2154160889 hasConcept C44249647 @default.
• W2154160889 hasConcept C526584372 @default.
• W2154160889 hasConcept C71924100 @default.
• W2154160889 hasConcept C99454951 @default.
• W2154160889 hasConceptScore W2154160889C126322002 @default.
• W2154160889 hasConceptScore W2154160889C126894567 @default.
• W2154160889 hasConceptScore W2154160889C141071460 @default.
• W2154160889 hasConceptScore W2154160889C143998085 @default.
• W2154160889 hasConceptScore W2154160889C207103383 @default.
• W2154160889 hasConceptScore W2154160889C2777472916 @default.

• next