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- W2154166543 abstract "Several recent studies have implicated myeloid cells in providing a microenvironment that promotes tumor cell survival and metastasis, therefore preparing a “premetastatic niche” for cancer progression. In this issue of the European Journal of Immunology , Zhang et al. [ Eur. J. Immunol . 2015. 45: 71–81] address the regulation of immune cells in premetastatic lymph nodes in experimental mouse models. The authors show that signal transducer and activator of transcription 3 (STAT3) ablation in murine myeloid cells, which renders the premetastatic niche less receptive to metastasis by B16 melanoma cells, also leads to local activation in the niche of CD8 + T cells with increased expression of IFN‐γ and granzyme B. Data further suggest that STAT3 activation in the myeloid population leads to poor tumor antigen presenting capacity as well as resistance to CD8 + T‐cell killing. Based on these studies in mice and observations in human cancer patients, the authors propose treatments designed to regulate STAT3 activation, which are correlated with increased cytolytic activity of CD8 + T cells in mouse models." @default.
- W2154166543 created "2016-06-24" @default.
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- W2154166543 date "2015-01-01" @default.
- W2154166543 modified "2023-09-25" @default.
- W2154166543 title "Silence STAT3 in the procancer niche…and activate CD8<sup>+</sup>T cells to kill premetastatic myeloid intruders" @default.
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- W2154166543 doi "https://doi.org/10.1002/eji.201445300" @default.
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