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- W2154180317 endingPage "400" @default.
- W2154180317 startingPage "357" @default.
- W2154180317 abstract "Mechanism-based PK-PD models differ from conventional PK-PD models in that they contain specific expressions to characterize, in a quantitative manner, processes on the causal path between drug administration and effect. This includes target site distribution, target binding and activation, pharmacodynamic interactions, transduction, and homeostatic feedback mechanisms. As the final step, the effects on disease processes and disease progression are considered. Particularly through the incorporation of concepts from receptor theory and dynamical systems analysis, important progress has been made in the field of mechanism-based PK-PD modeling. This has yielded models with much-improved properties for extrapolation and prediction. These models constitute a theoretical basis for rational drug discovery and development." @default.
- W2154180317 created "2016-06-24" @default.
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- W2154180317 creator A5033133140 @default.
- W2154180317 creator A5081960928 @default.
- W2154180317 date "2007-02-01" @default.
- W2154180317 modified "2023-09-26" @default.
- W2154180317 title "Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling: Biophase Distribution, Receptor Theory, and Dynamical Systems Analysis" @default.
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