FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154183756> ?p ?o ?g. }

• W2154183756 abstract "The maintenance of optimal steroidogenesis in adrenocortical cells primarily depends on the chronic action of cAMP. Herein we examine the effects of prostaglandin E2 (PGE2) on the differentiated functions of bovine adrenocortical (BAC) cells in primary culture. PGE2 (10 microM) treatment for 3 h stimulated steroidogenesis and cAMP production by over 100-fold. In addition, the cAMP antagonist Rp-cAMP (1 mM) inhibited PGE2 stimulation of steroidogenesis by 60%. This observation suggests that the cAMP second messenger system is responsible for much of the PGE2-activated steroid hormone synthesis. Chronic treatment of BAC cells with PGE2 caused induction of 3 beta-hydroxysteroid dehydrogenase and steroid 17 alpha-hydroxylase cytochrome P-450 expression as determined by the examination of enzyme activity, enzyme levels by immunoblotting, and specific messenger RNA (mRNA) levels by Northern analysis. The positive effects of PGE2 on expression of 3 beta-hydroxysteroid dehydrogenase and 17 alpha-hydroxylase cytochrome P-450 were similar to the effects seen after ACTH treatment of BAC cells. In addition, treatment of BAC cells with PGE2 for 3 days caused a 3-fold induction of ACTH receptors as determined by increased cell binding of [125I]ACTH. Finally, we determined that BAC cells produced PGE2 and that the level of synthesis increased 10-fold after treatment with the hormone angiotensin II. Taken together these data indicate that PGE2 is a positive regulator of BAC cell differentiation acting on ACTH receptors, steroid metabolizing enzymes, and steroidogenesis. The ability of BAC cells to produce PGE2 leaves open the possibility for paracrine and autocrine regulation within the adrenal." @default.
• W2154183756 created "2016-06-24" @default.
• W2154183756 creator A5021056317 @default.
• W2154183756 creator A5028770523 @default.
• W2154183756 creator A5062654290 @default.
• W2154183756 creator A5085226848 @default.
• W2154183756 date "1991-09-01" @default.
• W2154183756 modified "2023-09-23" @default.
• W2154183756 title "Prostaglandin E2Is a Positive Regulator of Adrenocorticotropin Receptors, 3β-Hydroxysteroid Dehydrogenase, and 17α-Hydroxylase Expression in Bovine Adrenocortical Cells*" @default.
• W2154183756 cites W1496688565 @default.
• W2154183756 cites W1526019385 @default.
• W2154183756 cites W1535953073 @default.
• W2154183756 cites W1536004934 @default.
• W2154183756 cites W1593329361 @default.
• W2154183756 cites W1965588433 @default.
• W2154183756 cites W1966603575 @default.
• W2154183756 cites W1974350281 @default.
• W2154183756 cites W1976829795 @default.
• W2154183756 cites W1987258923 @default.
• W2154183756 cites W1988701791 @default.
• W2154183756 cites W1993458009 @default.
• W2154183756 cites W1995601252 @default.
• W2154183756 cites W2029348336 @default.
• W2154183756 cites W2031235337 @default.
• W2154183756 cites W2037023622 @default.
• W2154183756 cites W2050281118 @default.
• W2154183756 cites W2090188464 @default.
• W2154183756 cites W2091493311 @default.
• W2154183756 cites W2125701765 @default.
• W2154183756 cites W2134812217 @default.
• W2154183756 cites W2236212752 @default.
• W2154183756 doi "https://doi.org/10.1210/endo-129-3-1333" @default.
• W2154183756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1651847" @default.
• W2154183756 hasPublicationYear "1991" @default.
• W2154183756 type Work @default.
• W2154183756 sameAs 2154183756 @default.
• W2154183756 citedByCount "30" @default.
• W2154183756 countsByYear W21541837562020 @default.
• W2154183756 crossrefType "journal-article" @default.
• W2154183756 hasAuthorship W2154183756A5021056317 @default.
• W2154183756 hasAuthorship W2154183756A5028770523 @default.
• W2154183756 hasAuthorship W2154183756A5062654290 @default.
• W2154183756 hasAuthorship W2154183756A5085226848 @default.
• W2154183756 hasConcept C126322002 @default.
• W2154183756 hasConcept C128240485 @default.
• W2154183756 hasConcept C134018914 @default.
• W2154183756 hasConcept C163235415 @default.
• W2154183756 hasConcept C170493617 @default.
• W2154183756 hasConcept C2776888042 @default.
• W2154183756 hasConcept C2777956040 @default.
• W2154183756 hasConcept C2780664492 @default.
• W2154183756 hasConcept C63263939 @default.
• W2154183756 hasConcept C71315377 @default.
• W2154183756 hasConcept C71924100 @default.
• W2154183756 hasConcept C7876069 @default.
• W2154183756 hasConcept C86803240 @default.
• W2154183756 hasConceptScore W2154183756C126322002 @default.
• W2154183756 hasConceptScore W2154183756C128240485 @default.
• W2154183756 hasConceptScore W2154183756C134018914 @default.
• W2154183756 hasConceptScore W2154183756C163235415 @default.
• W2154183756 hasConceptScore W2154183756C170493617 @default.
• W2154183756 hasConceptScore W2154183756C2776888042 @default.
• W2154183756 hasConceptScore W2154183756C2777956040 @default.
• W2154183756 hasConceptScore W2154183756C2780664492 @default.
• W2154183756 hasConceptScore W2154183756C63263939 @default.
• W2154183756 hasConceptScore W2154183756C71315377 @default.
• W2154183756 hasConceptScore W2154183756C71924100 @default.
• W2154183756 hasConceptScore W2154183756C7876069 @default.
• W2154183756 hasConceptScore W2154183756C86803240 @default.
• W2154183756 hasLocation W21541837561 @default.
• W2154183756 hasLocation W21541837562 @default.
• W2154183756 hasOpenAccess W2154183756 @default.
• W2154183756 hasPrimaryLocation W21541837561 @default.
• W2154183756 hasRelatedWork W1988854740 @default.
• W2154183756 hasRelatedWork W1995920009 @default.
• W2154183756 hasRelatedWork W2007817553 @default.
• W2154183756 hasRelatedWork W2016034363 @default.
• W2154183756 hasRelatedWork W2030506393 @default.
• W2154183756 hasRelatedWork W2038625466 @default.
• W2154183756 hasRelatedWork W2092156741 @default.
• W2154183756 hasRelatedWork W2120990491 @default.
• W2154183756 hasRelatedWork W2154183756 @default.
• W2154183756 hasRelatedWork W4243090233 @default.
• W2154183756 isParatext "false" @default.
• W2154183756 isRetracted "false" @default.
• W2154183756 magId "2154183756" @default.
• W2154183756 workType "article" @default.