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• W2154189654 abstract "Abstract The synthesis and in vitro anticancer activity of dihalogenido(η 6 ‐ p ‐cymene)(3,5,6‐bicyclophosphite‐α‐ D ‐glucofuranoside)ruthenium(II) complexes are described. The compounds were characterized by NMR spectroscopy and ESI mass spectrometry, and the molecular structures of dichlorido‐, dibromido‐ and diiodido(η 6 ‐ p ‐cymene)(3,5,6‐bicyclophosphite‐1,2‐ O ‐isopropylidene‐α‐ D ‐glucofuranoside)ruthenium(II) were determined by X‐ray diffraction analysis. The complexes were shown to undergo aquation of the first halido ligand in aqueous solution, followed by hydrolysis of a PO bond of the phosphite ligand, and finally formation of dinuclear species. The hydrolysis mechanism was confirmed by DFT calculations. The aquation of the complexes was markedly suppressed in 100 m M NaCl solution, and notably only very slow hydrolysis of the PO bond was observed. The complexes showed affinity towards albumin and transferrin and monoadduct formation with 9‐ethylguanine. In vitro studies revealed that the 3,5,6‐bicyclophosphite‐1,2‐ O ‐cyclohexylidene‐α‐ D ‐glucofuranoside complex is the most cytotoxic compound in human cancer cell lines (IC 50 values from 30 to 300 μ M depending on the cell line)." @default.
• W2154189654 created "2016-06-24" @default.
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• W2154189654 date "2008-08-08" @default.
• W2154189654 modified "2023-10-17" @default.
• W2154189654 title "In Vitro Anticancer Activity and Biologically Relevant Metabolization of Organometallic Ruthenium Complexes with Carbohydrate‐Based Ligands" @default.
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• W2154189654 doi "https://doi.org/10.1002/chem.200801032" @default.
• W2154189654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18688905" @default.
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