Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154192697> ?p ?o ?g. }
- W2154192697 endingPage "519" @default.
- W2154192697 startingPage "509" @default.
- W2154192697 abstract "Thrombospondin (TSP)-1 has been reported to modulate T cell behavior both positively and negatively. We found that these opposing responses arise from interactions of TSP1 with two different T cell receptors. The integrin alpha4beta1 recognizes an LDVP sequence in the NH2-terminal domain of TSP1 and was required for stimulation of T cell adhesion, chemotaxis, and matrix metalloproteinase gene expression by TSP1. Recognition of TSP1 by T cells depended on the activation state of alpha4beta1 integrin, and TSP1 inhibited interaction of activated alpha4beta1 integrin on T cells with its counter receptor vascular cell adhesion molecule-1. The alpha4beta1 integrin recognition site is conserved in TSP2. A recombinant piece of TSP2 containing this sequence replicated the alpha4beta1 integrin-dependent activities of TSP1. The beta1 integrin recognition sites in TSP1, however, were neither necessary nor sufficient for inhibition of T cell proliferation and T cell antigen receptor signaling by TSP1. A second TSP1 receptor, CD47, was not required for some stimulatory responses to TSP1 but played a significant role in its T cell antigen receptor antagonist and antiproliferative activities. Modulating the relative expression or function of these two TSP receptors could therefore alter the direction or magnitude of T cell responses to TSPs." @default.
- W2154192697 created "2016-06-24" @default.
- W2154192697 creator A5010985672 @default.
- W2154192697 creator A5030642152 @default.
- W2154192697 creator A5031078822 @default.
- W2154192697 creator A5037893640 @default.
- W2154192697 creator A5047294334 @default.
- W2154192697 creator A5051433481 @default.
- W2154192697 creator A5070007580 @default.
- W2154192697 creator A5086311823 @default.
- W2154192697 date "2002-04-29" @default.
- W2154192697 modified "2023-10-14" @default.
- W2154192697 title "Interactions of thrombospondins with α4β1 integrin and CD47 differentially modulate T cell behavior" @default.
- W2154192697 cites W1475256780 @default.
- W2154192697 cites W1486248177 @default.
- W2154192697 cites W1501495997 @default.
- W2154192697 cites W1516808533 @default.
- W2154192697 cites W1552764442 @default.
- W2154192697 cites W1573399724 @default.
- W2154192697 cites W1578883193 @default.
- W2154192697 cites W1581859519 @default.
- W2154192697 cites W1590204800 @default.
- W2154192697 cites W1592843561 @default.
- W2154192697 cites W1603286011 @default.
- W2154192697 cites W169514863 @default.
- W2154192697 cites W171857081 @default.
- W2154192697 cites W1812675070 @default.
- W2154192697 cites W1909472247 @default.
- W2154192697 cites W1933742170 @default.
- W2154192697 cites W1964632069 @default.
- W2154192697 cites W1973983795 @default.
- W2154192697 cites W1979318414 @default.
- W2154192697 cites W1980438007 @default.
- W2154192697 cites W1983956381 @default.
- W2154192697 cites W1985106556 @default.
- W2154192697 cites W2002220495 @default.
- W2154192697 cites W2003700021 @default.
- W2154192697 cites W2004374847 @default.
- W2154192697 cites W2010988562 @default.
- W2154192697 cites W2019784233 @default.
- W2154192697 cites W2022653506 @default.
- W2154192697 cites W2024704643 @default.
- W2154192697 cites W2038048357 @default.
- W2154192697 cites W2045447884 @default.
- W2154192697 cites W2046761301 @default.
- W2154192697 cites W2069911462 @default.
- W2154192697 cites W2076523264 @default.
- W2154192697 cites W2084747730 @default.
- W2154192697 cites W2085777866 @default.
- W2154192697 cites W2085939705 @default.
- W2154192697 cites W2094504982 @default.
- W2154192697 cites W2096916633 @default.
- W2154192697 cites W2100458140 @default.
- W2154192697 cites W2102067914 @default.
- W2154192697 cites W2102598791 @default.
- W2154192697 cites W2105516199 @default.
- W2154192697 cites W2106764575 @default.
- W2154192697 cites W2108992054 @default.
- W2154192697 cites W2122360544 @default.
- W2154192697 cites W2144267004 @default.
- W2154192697 cites W2149360108 @default.
- W2154192697 cites W2155112713 @default.
- W2154192697 cites W2157015192 @default.
- W2154192697 cites W2159913536 @default.
- W2154192697 cites W2168324886 @default.
- W2154192697 cites W4231813115 @default.
- W2154192697 cites W4285719527 @default.
- W2154192697 cites W4299736390 @default.
- W2154192697 cites W4312444143 @default.
- W2154192697 cites W4313335049 @default.
- W2154192697 cites W4313422310 @default.
- W2154192697 doi "https://doi.org/10.1083/jcb.200109098" @default.
- W2154192697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2173289" @default.
- W2154192697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11980922" @default.
- W2154192697 hasPublicationYear "2002" @default.
- W2154192697 type Work @default.
- W2154192697 sameAs 2154192697 @default.
- W2154192697 citedByCount "132" @default.
- W2154192697 countsByYear W21541926972012 @default.
- W2154192697 countsByYear W21541926972013 @default.
- W2154192697 countsByYear W21541926972014 @default.
- W2154192697 countsByYear W21541926972015 @default.
- W2154192697 countsByYear W21541926972016 @default.
- W2154192697 countsByYear W21541926972017 @default.
- W2154192697 countsByYear W21541926972018 @default.
- W2154192697 countsByYear W21541926972019 @default.
- W2154192697 countsByYear W21541926972020 @default.
- W2154192697 countsByYear W21541926972021 @default.
- W2154192697 countsByYear W21541926972022 @default.
- W2154192697 countsByYear W21541926972023 @default.
- W2154192697 crossrefType "journal-article" @default.
- W2154192697 hasAuthorship W2154192697A5010985672 @default.
- W2154192697 hasAuthorship W2154192697A5030642152 @default.
- W2154192697 hasAuthorship W2154192697A5031078822 @default.
- W2154192697 hasAuthorship W2154192697A5037893640 @default.
- W2154192697 hasAuthorship W2154192697A5047294334 @default.
- W2154192697 hasAuthorship W2154192697A5051433481 @default.
- W2154192697 hasAuthorship W2154192697A5070007580 @default.