Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154196108> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2154196108 abstract "The effects of propylbutyldopamine ( PBDA ), an analog of dopamine lacking significant vasoconstrictor effects, were examined in seven patients with essential hypertension. Cardiovascular hemodynamics, renal plasma flow, urinary sodium excretion, and the renin-angiotensin-aldosterone system were examined during PBDA infusion both before and after administration of low (8 micrograms/kg) and high (40 micrograms/kg) doses of the dopamine receptor antagonist metoclopramide. Infusion of PBDA at a rate of 20 micrograms/kg/min lowered mean arterial pressure from an average control value of 112 +/- 4 to 94 +/- 3 mm Hg during the last 5 minutes of infusion (p less than 0.01), and increased effective renal plasma flow from 330 +/- 22 ml/min to 591 +/- 46 ml/min (p less than 0.01). Changes in heart rate (+ 16% +/- 5% increase from control values of 77 +/- 3 bpm), urinary sodium excretion (+ 13% +/- 5% increase from control value of 121 +/- 11 muEq/min), plasma renin activity (+ 23% +/- 15% increase over control value of 1.3 +/- 0.3 ng angiotensin I/ml/hr), and plasma aldosterone (+ 26% +/- 12% increase over control value of 17 +/- 6 ng/dl) accompanied PBDA infusion. Pretreatment with metoclopramide at a dose of 8 micrograms/kg prior to PBDA infusion partially blunted the blood pressure reduction produced by PBDA alone (-10% +/- 8% vs -20% +/- 4% compared to control values, p less than 0.1) but had no effect on PBDA -induced increases in renal plasma flow (+ 179% +/- 15% vs + 179% +/- 9% compared to control).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2154196108 created "2016-06-24" @default.
- W2154196108 creator A5025872811 @default.
- W2154196108 creator A5029958756 @default.
- W2154196108 creator A5043120251 @default.
- W2154196108 creator A5067569085 @default.
- W2154196108 creator A5079320024 @default.
- W2154196108 creator A5079818414 @default.
- W2154196108 creator A5053429563 @default.
- W2154196108 date "1984-03-01" @default.
- W2154196108 modified "2023-09-27" @default.
- W2154196108 title "Propylbutyldopamine. Mechanism of blood pressure lowering in hypertensive patients." @default.
- W2154196108 doi "https://doi.org/10.1161/01.hyp.6.2_pt_2.i40" @default.
- W2154196108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6373598" @default.
- W2154196108 hasPublicationYear "1984" @default.
- W2154196108 type Work @default.
- W2154196108 sameAs 2154196108 @default.
- W2154196108 citedByCount "11" @default.
- W2154196108 crossrefType "journal-article" @default.
- W2154196108 hasAuthorship W2154196108A5025872811 @default.
- W2154196108 hasAuthorship W2154196108A5029958756 @default.
- W2154196108 hasAuthorship W2154196108A5043120251 @default.
- W2154196108 hasAuthorship W2154196108A5053429563 @default.
- W2154196108 hasAuthorship W2154196108A5067569085 @default.
- W2154196108 hasAuthorship W2154196108A5079320024 @default.
- W2154196108 hasAuthorship W2154196108A5079818414 @default.
- W2154196108 hasConcept C126322002 @default.
- W2154196108 hasConcept C134018914 @default.
- W2154196108 hasConcept C138976137 @default.
- W2154196108 hasConcept C142225936 @default.
- W2154196108 hasConcept C170493617 @default.
- W2154196108 hasConcept C174459258 @default.
- W2154196108 hasConcept C178853913 @default.
- W2154196108 hasConcept C185592680 @default.
- W2154196108 hasConcept C198710026 @default.
- W2154196108 hasConcept C2776885963 @default.
- W2154196108 hasConcept C2777097880 @default.
- W2154196108 hasConcept C2777953023 @default.
- W2154196108 hasConcept C2778479196 @default.
- W2154196108 hasConcept C2778525890 @default.
- W2154196108 hasConcept C2780852908 @default.
- W2154196108 hasConcept C71924100 @default.
- W2154196108 hasConcept C84393581 @default.
- W2154196108 hasConceptScore W2154196108C126322002 @default.
- W2154196108 hasConceptScore W2154196108C134018914 @default.
- W2154196108 hasConceptScore W2154196108C138976137 @default.
- W2154196108 hasConceptScore W2154196108C142225936 @default.
- W2154196108 hasConceptScore W2154196108C170493617 @default.
- W2154196108 hasConceptScore W2154196108C174459258 @default.
- W2154196108 hasConceptScore W2154196108C178853913 @default.
- W2154196108 hasConceptScore W2154196108C185592680 @default.
- W2154196108 hasConceptScore W2154196108C198710026 @default.
- W2154196108 hasConceptScore W2154196108C2776885963 @default.
- W2154196108 hasConceptScore W2154196108C2777097880 @default.
- W2154196108 hasConceptScore W2154196108C2777953023 @default.
- W2154196108 hasConceptScore W2154196108C2778479196 @default.
- W2154196108 hasConceptScore W2154196108C2778525890 @default.
- W2154196108 hasConceptScore W2154196108C2780852908 @default.
- W2154196108 hasConceptScore W2154196108C71924100 @default.
- W2154196108 hasConceptScore W2154196108C84393581 @default.
- W2154196108 hasLocation W21541961081 @default.
- W2154196108 hasLocation W21541961082 @default.
- W2154196108 hasOpenAccess W2154196108 @default.
- W2154196108 hasPrimaryLocation W21541961081 @default.
- W2154196108 hasRelatedWork W1799770855 @default.
- W2154196108 hasRelatedWork W1976450327 @default.
- W2154196108 hasRelatedWork W2008843078 @default.
- W2154196108 hasRelatedWork W2031633633 @default.
- W2154196108 hasRelatedWork W2046181838 @default.
- W2154196108 hasRelatedWork W2069201996 @default.
- W2154196108 hasRelatedWork W2089546849 @default.
- W2154196108 hasRelatedWork W2116710690 @default.
- W2154196108 hasRelatedWork W2154238872 @default.
- W2154196108 hasRelatedWork W2167503593 @default.
- W2154196108 isParatext "false" @default.
- W2154196108 isRetracted "false" @default.
- W2154196108 magId "2154196108" @default.
- W2154196108 workType "article" @default.