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- W2154200122 abstract "Thiocyanate hydrolase (SCNase) is a member of a family of nitrile hydratase proteins, each of which contains a unique noncorrin cobalt center with two post-translationally modified cysteine ligands, cysteine-sulfenic acid or -sulfenate (Cys-SO(H)), and cysteine-sulfininate (Cys-SO2−), respectively. We have found that a partially matured recombinant SCNase was activated during storage. The crystal structures of SCNase before and after storage demonstrated that Cys-SO2− modification of γCys131 proceeded to completion prior to storage, while Cys-SO(H) modification of γCys133 occurred during storage. SCNase activity was suppressed when γCys133 was further oxidized to Cys-SO2−. The correlation between the catalytic activity and the extent of the γCys133 modification indicates that the cysteine sulfenic acid modification of γCys133 is of primary importance in determining the activity of SCNase." @default.
- W2154200122 created "2016-06-24" @default.
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- W2154200122 date "2009-09-28" @default.
- W2154200122 modified "2023-10-03" @default.
- W2154200122 title "Structural Basis for Catalytic Activation of Thiocyanate Hydrolase Involving Metal-Ligated Cysteine Modification" @default.
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- W2154200122 doi "https://doi.org/10.1021/ja903979s" @default.
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