FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154201208> ?p ?o ?g. }

• W2154201208 endingPage "537" @default.
• W2154201208 startingPage "530" @default.
• W2154201208 abstract "Rheumatoid arthritis (RA) is an autoimmune disease characterized by a persistent inflammation of the synovium, leading to the erosion of articular cartilage and bone. Synovial mast cells and their effector molecule, histamine, receive increased attention as mediators of joint inflammation. The aim of our study was to analyse levels of free histamine in serum and joint fluid of RA patients and to evaluate the potential inflammatogenic properties of histamine in vivo and in vitro. Histamine levels were measured by an ELISA in synovial fluid and sera of RA patients and of healthy controls. Histamine levels were also assessed in plasma of RA patients undergoing anti-TNF-alpha treatment. In the murine part of the study, histamine was injected intra-articularly in the knee joint of mice and the joints were subsequently analysed with respect to induction of inflammation. RA patients displayed significantly lower levels of histamine in circulation (0.93 +/- 0.16 ng/ml) compared with the healthy controls (1.89 +/- 0.45 ng/ml, P < 0.001). Locally, in synovial fluid the levels of histamine were even lower (0.37 +/- 0.16 ng/ml, P < 0.0006). Long-term anti-TNF-alpha treatment significantly increased circulating levels of histamine in RA patients. Our experiments on animals show that histamine on its own neither induces inflammation in the joint cavity nor influences the course of HMGB1 and peptidoglycan-induced joint inflammation. Based on our experimental and clinical studies we suggest that histamine lacks harmful properties in RA." @default.
• W2154201208 created "2016-06-24" @default.
• W2154201208 creator A5006114293 @default.
• W2154201208 creator A5060447636 @default.
• W2154201208 creator A5060762135 @default.
• W2154201208 creator A5066540554 @default.
• W2154201208 creator A5077760995 @default.
• W2154201208 creator A5082065959 @default.
• W2154201208 date "2007-04-27" @default.
• W2154201208 modified "2023-10-15" @default.
• W2154201208 title "Histamine in Rheumatoid Arthritis" @default.
• W2154201208 cites W101168984 @default.
• W2154201208 cites W1518773720 @default.
• W2154201208 cites W1866450000 @default.
• W2154201208 cites W1965064476 @default.
• W2154201208 cites W1965797391 @default.
• W2154201208 cites W1970276392 @default.
• W2154201208 cites W1970443937 @default.
• W2154201208 cites W1970773503 @default.
• W2154201208 cites W1982564040 @default.
• W2154201208 cites W1982709334 @default.
• W2154201208 cites W1983547673 @default.
• W2154201208 cites W1985829399 @default.
• W2154201208 cites W1995367099 @default.
• W2154201208 cites W1995706449 @default.
• W2154201208 cites W2011969605 @default.
• W2154201208 cites W2026948765 @default.
• W2154201208 cites W2031092466 @default.
• W2154201208 cites W2032813553 @default.
• W2154201208 cites W2034486057 @default.
• W2154201208 cites W2045195033 @default.
• W2154201208 cites W2049488549 @default.
• W2154201208 cites W2049670226 @default.
• W2154201208 cites W2053245285 @default.
• W2154201208 cites W2053365158 @default.
• W2154201208 cites W2055928479 @default.
• W2154201208 cites W2063014779 @default.
• W2154201208 cites W2069480770 @default.
• W2154201208 cites W2072011504 @default.
• W2154201208 cites W2080731522 @default.
• W2154201208 cites W2081941033 @default.
• W2154201208 cites W2087130669 @default.
• W2154201208 cites W2102291237 @default.
• W2154201208 cites W2127806486 @default.
• W2154201208 cites W2132002566 @default.
• W2154201208 cites W2140611998 @default.
• W2154201208 cites W2141778744 @default.
• W2154201208 cites W2149501430 @default.
• W2154201208 cites W2157492214 @default.
• W2154201208 cites W2160522527 @default.
• W2154201208 cites W2169475850 @default.
• W2154201208 cites W2271429882 @default.
• W2154201208 cites W4247100325 @default.
• W2154201208 cites W2005861554 @default.
• W2154201208 doi "https://doi.org/10.1111/j.1365-3083.2007.01938.x" @default.
• W2154201208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17523945" @default.
• W2154201208 hasPublicationYear "2007" @default.
• W2154201208 type Work @default.
• W2154201208 sameAs 2154201208 @default.
• W2154201208 citedByCount "34" @default.
• W2154201208 countsByYear W21542012082012 @default.
• W2154201208 countsByYear W21542012082013 @default.
• W2154201208 countsByYear W21542012082014 @default.
• W2154201208 countsByYear W21542012082015 @default.
• W2154201208 countsByYear W21542012082017 @default.
• W2154201208 countsByYear W21542012082018 @default.
• W2154201208 countsByYear W21542012082019 @default.
• W2154201208 countsByYear W21542012082021 @default.
• W2154201208 countsByYear W21542012082022 @default.
• W2154201208 crossrefType "journal-article" @default.
• W2154201208 hasAuthorship W2154201208A5006114293 @default.
• W2154201208 hasAuthorship W2154201208A5060447636 @default.
• W2154201208 hasAuthorship W2154201208A5060762135 @default.
• W2154201208 hasAuthorship W2154201208A5066540554 @default.
• W2154201208 hasAuthorship W2154201208A5077760995 @default.
• W2154201208 hasAuthorship W2154201208A5082065959 @default.
• W2154201208 hasBestOaLocation W21542012081 @default.
• W2154201208 hasConcept C1122143 @default.
• W2154201208 hasConcept C126322002 @default.
• W2154201208 hasConcept C134018914 @default.
• W2154201208 hasConcept C142724271 @default.
• W2154201208 hasConcept C150903083 @default.
• W2154201208 hasConcept C17991360 @default.
• W2154201208 hasConcept C203014093 @default.
• W2154201208 hasConcept C204787440 @default.
• W2154201208 hasConcept C207001950 @default.
• W2154201208 hasConcept C2776164576 @default.
• W2154201208 hasConcept C2776268809 @default.
• W2154201208 hasConcept C2776914184 @default.
• W2154201208 hasConcept C2777077863 @default.
• W2154201208 hasConcept C2777575956 @default.
• W2154201208 hasConcept C71924100 @default.
• W2154201208 hasConcept C86803240 @default.
• W2154201208 hasConceptScore W2154201208C1122143 @default.
• W2154201208 hasConceptScore W2154201208C126322002 @default.
• W2154201208 hasConceptScore W2154201208C134018914 @default.
• W2154201208 hasConceptScore W2154201208C142724271 @default.
• W2154201208 hasConceptScore W2154201208C150903083 @default.

• next