FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154216044> ?p ?o ?g. }

• W2154216044 endingPage "28" @default.
• W2154216044 startingPage "11" @default.
• W2154216044 abstract "Anticonvulsant tests in mice revealed specific, potent actions of remacemide for protection of mice against maximal electroshock seizures (MES). Comparisons of oral efficacy to reference compounds yielded the following ED50 values (expressed as mg/kg): remacemide = 33, phenytoin = 11, phenobarbital = 20, carbamazepine = 13 and valproate = 631. The duration for protection by remacemide was longer than carbamazepine or valproate, but shorter than phenytoin or phenobarbital. In neural impairment tests (inverted screen or rotorod) to determine the oral toxic dose 50 (TD50) the following therapeutic indices (TD50/ED50) were obtained: (1) inverted screen--remacemide = 17.6, phenytoin = 57.4, phenobarbital = 5.1, carbamazepine = 10.2, and valproate = greater than 3; and (2) rotorod--remacemide = 5.6, phenytoin = 9.6, phenobarbital 4.8, and valproate = 1.9. Remacemide was devoid of sedative actions and possessed a favorable 28.1 margin of safety value (median estimated lethal dose/ED50 for MES). An intermediate potency against either audiogenic- or N-methyl-D-aspartate-induced seizures was exhibited by remacemide. Tolerance to MES was not apparent after 5 days of oral daily dosing of remacemide. Remacemide was inactive in vitro against gamma-aminobutyrate or benzodiazepine receptors and adenosine uptake mechanisms. Therapeutic utility for generalized tonic/clonic seizures is predicted for remacemide." @default.
• W2154216044 created "2016-06-24" @default.
• W2154216044 creator A5007519941 @default.
• W2154216044 creator A5008446035 @default.
• W2154216044 creator A5018288672 @default.
• W2154216044 creator A5024167731 @default.
• W2154216044 creator A5033804334 @default.
• W2154216044 creator A5035955440 @default.
• W2154216044 creator A5040410472 @default.
• W2154216044 creator A5046161111 @default.
• W2154216044 creator A5062498742 @default.
• W2154216044 creator A5072075379 @default.
• W2154216044 creator A5077517723 @default.
• W2154216044 creator A5088706930 @default.
• W2154216044 date "1990-09-01" @default.
• W2154216044 modified "2023-10-17" @default.
• W2154216044 title "Preclinical profile of remacemide: A novel anticonvulsant effective against maximal electroshock seizures in mice" @default.
• W2154216044 cites W1989081373 @default.
• W2154216044 cites W2014377627 @default.
• W2154216044 cites W2023281672 @default.
• W2154216044 cites W2023292449 @default.
• W2154216044 cites W2029551783 @default.
• W2154216044 cites W2037997999 @default.
• W2154216044 cites W2050886880 @default.
• W2154216044 cites W2058038524 @default.
• W2154216044 cites W2066628109 @default.
• W2154216044 cites W2069091414 @default.
• W2154216044 cites W2073063680 @default.
• W2154216044 cites W2117614741 @default.
• W2154216044 cites W2131113890 @default.
• W2154216044 cites W2153335219 @default.
• W2154216044 cites W2166727698 @default.
• W2154216044 cites W2206743521 @default.
• W2154216044 cites W2320058521 @default.
• W2154216044 cites W2323471917 @default.
• W2154216044 cites W4246603556 @default.
• W2154216044 doi "https://doi.org/10.1016/0920-1211(90)90050-6" @default.
• W2154216044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1963406" @default.
• W2154216044 hasPublicationYear "1990" @default.
• W2154216044 type Work @default.
• W2154216044 sameAs 2154216044 @default.
• W2154216044 citedByCount "36" @default.
• W2154216044 countsByYear W21542160442013 @default.
• W2154216044 countsByYear W21542160442015 @default.
• W2154216044 countsByYear W21542160442019 @default.
• W2154216044 countsByYear W21542160442021 @default.
• W2154216044 crossrefType "journal-article" @default.
• W2154216044 hasAuthorship W2154216044A5007519941 @default.
• W2154216044 hasAuthorship W2154216044A5008446035 @default.
• W2154216044 hasAuthorship W2154216044A5018288672 @default.
• W2154216044 hasAuthorship W2154216044A5024167731 @default.
• W2154216044 hasAuthorship W2154216044A5033804334 @default.
• W2154216044 hasAuthorship W2154216044A5035955440 @default.
• W2154216044 hasAuthorship W2154216044A5040410472 @default.
• W2154216044 hasAuthorship W2154216044A5046161111 @default.
• W2154216044 hasAuthorship W2154216044A5062498742 @default.
• W2154216044 hasAuthorship W2154216044A5072075379 @default.
• W2154216044 hasAuthorship W2154216044A5077517723 @default.
• W2154216044 hasAuthorship W2154216044A5088706930 @default.
• W2154216044 hasConcept C118552586 @default.
• W2154216044 hasConcept C185592680 @default.
• W2154216044 hasConcept C202751555 @default.
• W2154216044 hasConcept C2775858608 @default.
• W2154216044 hasConcept C2778186239 @default.
• W2154216044 hasConcept C2778337148 @default.
• W2154216044 hasConcept C2778793413 @default.
• W2154216044 hasConcept C2779253243 @default.
• W2154216044 hasConcept C42533223 @default.
• W2154216044 hasConcept C55493867 @default.
• W2154216044 hasConcept C71924100 @default.
• W2154216044 hasConcept C98274493 @default.
• W2154216044 hasConceptScore W2154216044C118552586 @default.
• W2154216044 hasConceptScore W2154216044C185592680 @default.
• W2154216044 hasConceptScore W2154216044C202751555 @default.
• W2154216044 hasConceptScore W2154216044C2775858608 @default.
• W2154216044 hasConceptScore W2154216044C2778186239 @default.
• W2154216044 hasConceptScore W2154216044C2778337148 @default.
• W2154216044 hasConceptScore W2154216044C2778793413 @default.
• W2154216044 hasConceptScore W2154216044C2779253243 @default.
• W2154216044 hasConceptScore W2154216044C42533223 @default.
• W2154216044 hasConceptScore W2154216044C55493867 @default.
• W2154216044 hasConceptScore W2154216044C71924100 @default.
• W2154216044 hasConceptScore W2154216044C98274493 @default.
• W2154216044 hasIssue "1" @default.
• W2154216044 hasLocation W21542160441 @default.
• W2154216044 hasLocation W21542160442 @default.
• W2154216044 hasOpenAccess W2154216044 @default.
• W2154216044 hasPrimaryLocation W21542160441 @default.
• W2154216044 hasRelatedWork W1633937204 @default.
• W2154216044 hasRelatedWork W1966607521 @default.
• W2154216044 hasRelatedWork W2089746798 @default.
• W2154216044 hasRelatedWork W2091725191 @default.
• W2154216044 hasRelatedWork W2154216044 @default.
• W2154216044 hasRelatedWork W2410834294 @default.
• W2154216044 hasRelatedWork W2906906539 @default.
• W2154216044 hasRelatedWork W2998257553 @default.
• W2154216044 hasRelatedWork W3098373555 @default.
• W2154216044 hasRelatedWork W4229626802 @default.

• next