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• W2154221780 endingPage "4062" @default.
• W2154221780 startingPage "4052" @default.
• W2154221780 abstract "The tyrosine kinase JAK2 is a key signaling protein for at least 20 receptors in the cytokine/hematopoietin receptor superfamily and is a component of signaling for multiple receptor tyrosine kinases and several G-protein-coupled receptors. In this study, phosphopeptide affinity enrichment and mass spectrometry identified serine 523 (Ser523) in JAK2 as a site of phosphorylation. A phosphoserine 523 antibody revealed that Ser523 is rapidly but transiently phosphorylated in response to growth hormone (GH). MEK1 inhibitor UO126 suppresses GH-dependent phosphorylation of Ser523, suggesting that extracellular signal-regulated kinases (ERKs) 1 and/or 2 or another kinase downstream of MEK1 phosphorylate Ser523 in response to GH. Other ERK activators, phorbol 12-myristate 13-acetate and epidermal growth factor, also stimulate phosphorylation of Ser523. When Ser523 in JAK2 was mutated, JAK2 kinase activity as well as GH-dependent tyrosyl phosphorylation of JAK2 and Stat5 was enhanced, suggesting that phosphorylation of Ser523 inhibits JAK2 kinase activity. We hypothesize that phosphorylation of Ser523 in JAK2 by ERKs 1 and/or 2 or other as-yet-unidentified kinases acts in a negative feedback manner to dampen activation of JAK2 in response to GH and provides a mechanism by which prior exposure to environmental factors that regulate Ser523 phosphorylation might modulate the cell's response to GH." @default.
• W2154221780 created "2016-06-24" @default.
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• W2154221780 creator A5068567990 @default.
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• W2154221780 creator A5089134677 @default.
• W2154221780 date "2006-06-01" @default.
• W2154221780 modified "2023-10-11" @default.
• W2154221780 title "Phosphorylation of JAK2 at Serine 523: a Negative Regulator of JAK2 That Is Stimulated by GrowthHormone and Epidermal Growth Factor" @default.
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• W2154221780 cites W1492596019 @default.
• W2154221780 cites W1505356419 @default.
• W2154221780 cites W1512072195 @default.
• W2154221780 cites W1525759724 @default.
• W2154221780 cites W1534981615 @default.
• W2154221780 cites W154122761 @default.
• W2154221780 cites W1547428329 @default.
• W2154221780 cites W1553799143 @default.
• W2154221780 cites W1558985898 @default.
• W2154221780 cites W1579739997 @default.
• W2154221780 cites W1608611896 @default.
• W2154221780 cites W1655072337 @default.
• W2154221780 cites W1679419992 @default.
• W2154221780 cites W1792395986 @default.
• W2154221780 cites W1932148910 @default.
• W2154221780 cites W1954929088 @default.
• W2154221780 cites W1964957919 @default.
• W2154221780 cites W1965571070 @default.
• W2154221780 cites W1968428021 @default.
• W2154221780 cites W1974607640 @default.
• W2154221780 cites W1974656027 @default.
• W2154221780 cites W1979799050 @default.
• W2154221780 cites W1980568348 @default.
• W2154221780 cites W1981149222 @default.
• W2154221780 cites W1984703212 @default.
• W2154221780 cites W1994885440 @default.
• W2154221780 cites W1996812850 @default.
• W2154221780 cites W2001215875 @default.
• W2154221780 cites W2001230322 @default.
• W2154221780 cites W2003659422 @default.
• W2154221780 cites W2006795381 @default.
• W2154221780 cites W2008295144 @default.
• W2154221780 cites W2009176064 @default.
• W2154221780 cites W2019030530 @default.
• W2154221780 cites W2025206161 @default.
• W2154221780 cites W2030865745 @default.
• W2154221780 cites W2034921169 @default.
• W2154221780 cites W2039362233 @default.
• W2154221780 cites W2039648580 @default.
• W2154221780 cites W2040507646 @default.
• W2154221780 cites W2041162439 @default.
• W2154221780 cites W2042054309 @default.
• W2154221780 cites W2042635419 @default.
• W2154221780 cites W2043911313 @default.
• W2154221780 cites W2044719429 @default.
• W2154221780 cites W2049145190 @default.
• W2154221780 cites W2057360098 @default.
• W2154221780 cites W2060159485 @default.
• W2154221780 cites W2067282472 @default.
• W2154221780 cites W2074184810 @default.
• W2154221780 cites W2074503465 @default.
• W2154221780 cites W2076897294 @default.
• W2154221780 cites W2077058506 @default.
• W2154221780 cites W2077166985 @default.
• W2154221780 cites W2077352509 @default.
• W2154221780 cites W2078594804 @default.
• W2154221780 cites W2086262311 @default.
• W2154221780 cites W2089269477 @default.
• W2154221780 cites W2104293639 @default.
• W2154221780 cites W2104485296 @default.
• W2154221780 cites W2106571571 @default.
• W2154221780 cites W2107796077 @default.
• W2154221780 cites W2108486371 @default.
• W2154221780 cites W2113674401 @default.
• W2154221780 cites W2114713566 @default.
• W2154221780 cites W2138165161 @default.
• W2154221780 cites W2139374729 @default.
• W2154221780 cites W2140786721 @default.
• W2154221780 cites W2144664431 @default.
• W2154221780 cites W2146228871 @default.
• W2154221780 cites W2148414191 @default.
• W2154221780 cites W2158602749 @default.
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• W2154221780 doi "https://doi.org/10.1128/mcb.01591-05" @default.
• W2154221780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1489095" @default.
• W2154221780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16705159" @default.
• W2154221780 hasPublicationYear "2006" @default.
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