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• W2154229715 abstract "Objectives To report normative data of nasal bone length (NBL) in first-trimester singleton fetuses in a normal cohort of Latin American women. Methods NBL was measured during routine first-trimester sonographic examination in 1040 singleton fetuses from an unselected population. Results NBL increased linearly with advancing gestational age (GA) [NBL (mm) = − 1.10 + 0.03 × GA (days), R2 = 0.21; p < 0.001]. Similarly, there was a linear relationship between the NBL and crown-lump length (CRL) [NBL (mm) = 0.41 + 0.02 × CRL (mm), R2 = 0.27; p < 0.001]. The NBLs at the 50th percentile in our population were 1.5, 1.7, and 1.9 mm at 11, 12, and 13 weeks of gestation, respectively. Conclusions Whereas categorizing a nasal bone as absent or present can be subjective because of variations in echogenicity due to technique and equipment, measurement of NBL is a more objective approach to nasal bone assessment in screening for aneuploidy. Measurement of NBL in the first trimester is feasible and can be easily obtained at the time of nuchal translucency assessment. The normative data we report can provide a reference for defining nasal bone hypoplasia in the first trimester in the Latin American population. Copyright © 2008 John Wiley & Sons, Ltd." @default.
• W2154229715 created "2016-06-24" @default.
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• W2154229715 date "2009-02-01" @default.
• W2154229715 modified "2023-10-06" @default.
• W2154229715 title "First-trimester nasal bone length in a normal Latin American population" @default.
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• W2154229715 doi "https://doi.org/10.1002/pd.2173" @default.
• W2154229715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19085962" @default.
• W2154229715 hasPublicationYear "2009" @default.
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