FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154233668> ?p ?o ?g. }

• W2154233668 endingPage "55" @default.
• W2154233668 startingPage "5049" @default.
• W2154233668 abstract "Anti-TNF-alpha treatment of rheumatoid arthritis patients markedly suppresses inflammatory disease activity, but so far no tissue-protective effects have been reported. In contrast, blockade of IL-1 in rheumatoid arthritis patients, by an IL-1 receptor antagonist, was only moderately effective in suppressing inflammatory symptoms but appeared to reduce the rate of progression of joint destruction. We therefore used an established collagen II murine arthritis model (collagen-induced arthritis(CIA)) to study effects on joint structures of neutralization of either TNF-alpha or IL-1. Both soluble TNF binding protein and anti-IL-1 treatment ameliorated disease activity when applied shortly after onset of CIA. Serum analysis revealed that early anti-TNF-alpha treatment of CIA did not decrease the process in the cartilage, as indicated by the elevated COMP levels. In contrast, anti-IL-1 treatment of established CIA normalized COMP levels, apparently alleviating the process in the tissue. Histology of knee and ankle joints corroborated the finding and showed that cartilage and joint destruction was significantly decreased after anti-IL-1 treatment but was hardly affected by anti-TNF-alpha treatment. Radiographic analysis of knee and ankle joints revealed that bone erosions were prevented by anti-IL-1 treatment, whereas the anti-TNF-alpha-treated animals exhibited changes comparable to the controls. In line with these findings, metalloproteinase activity, visualized by VDIPEN production, was almost absent throughout the cartilage layers in anti-IL-1-treated animals, whereas massive VDIPEN appearance was found in control and sTNFbp-treated mice. These results indicate that blocking of IL-1 is a cartilage- and bone-protective therapy in destructive arthritis, whereas the TNF-alpha antagonist has little effect on tissue destruction." @default.
• W2154233668 created "2016-06-24" @default.
• W2154233668 creator A5015932797 @default.
• W2154233668 creator A5023004311 @default.
• W2154233668 creator A5036752858 @default.
• W2154233668 creator A5045199963 @default.
• W2154233668 creator A5049232513 @default.
• W2154233668 creator A5074728058 @default.
• W2154233668 date "1999-11-01" @default.
• W2154233668 modified "2023-10-17" @default.
• W2154233668 title "IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation." @default.
• W2154233668 cites W1494656326 @default.
• W2154233668 cites W1517762857 @default.
• W2154233668 cites W1528765374 @default.
• W2154233668 cites W1766919565 @default.
• W2154233668 cites W1940973248 @default.
• W2154233668 cites W1978103379 @default.
• W2154233668 cites W1982353083 @default.
• W2154233668 cites W1995246567 @default.
• W2154233668 cites W2001660220 @default.
• W2154233668 cites W2029620160 @default.
• W2154233668 cites W2031670584 @default.
• W2154233668 cites W2033228977 @default.
• W2154233668 cites W2042812858 @default.
• W2154233668 cites W2043287930 @default.
• W2154233668 cites W2053625192 @default.
• W2154233668 cites W2055034098 @default.
• W2154233668 cites W2056813079 @default.
• W2154233668 cites W2062676485 @default.
• W2154233668 cites W2071832696 @default.
• W2154233668 cites W2081694240 @default.
• W2154233668 cites W2084030755 @default.
• W2154233668 cites W2085853581 @default.
• W2154233668 cites W2101840353 @default.
• W2154233668 cites W2124453416 @default.
• W2154233668 cites W2125723356 @default.
• W2154233668 cites W2128938421 @default.
• W2154233668 cites W2167031471 @default.
• W2154233668 cites W2168735834 @default.
• W2154233668 cites W2328587823 @default.
• W2154233668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10528210" @default.
• W2154233668 hasPublicationYear "1999" @default.
• W2154233668 type Work @default.
• W2154233668 sameAs 2154233668 @default.
• W2154233668 citedByCount "169" @default.
• W2154233668 countsByYear W21542336682012 @default.
• W2154233668 countsByYear W21542336682013 @default.
• W2154233668 countsByYear W21542336682014 @default.
• W2154233668 countsByYear W21542336682015 @default.
• W2154233668 countsByYear W21542336682016 @default.
• W2154233668 countsByYear W21542336682017 @default.
• W2154233668 countsByYear W21542336682018 @default.
• W2154233668 countsByYear W21542336682019 @default.
• W2154233668 countsByYear W21542336682020 @default.
• W2154233668 countsByYear W21542336682021 @default.
• W2154233668 countsByYear W21542336682022 @default.
• W2154233668 countsByYear W21542336682023 @default.
• W2154233668 crossrefType "journal-article" @default.
• W2154233668 hasAuthorship W2154233668A5015932797 @default.
• W2154233668 hasAuthorship W2154233668A5023004311 @default.
• W2154233668 hasAuthorship W2154233668A5036752858 @default.
• W2154233668 hasAuthorship W2154233668A5045199963 @default.
• W2154233668 hasAuthorship W2154233668A5049232513 @default.
• W2154233668 hasAuthorship W2154233668A5074728058 @default.
• W2154233668 hasConcept C105702510 @default.
• W2154233668 hasConcept C126322002 @default.
• W2154233668 hasConcept C134018914 @default.
• W2154233668 hasConcept C141071460 @default.
• W2154233668 hasConcept C170493617 @default.
• W2154233668 hasConcept C17991360 @default.
• W2154233668 hasConcept C203014093 @default.
• W2154233668 hasConcept C2775944032 @default.
• W2154233668 hasConcept C2776914184 @default.
• W2154233668 hasConcept C2777077863 @default.
• W2154233668 hasConcept C2777575956 @default.
• W2154233668 hasConcept C2778468042 @default.
• W2154233668 hasConcept C2780550940 @default.
• W2154233668 hasConcept C2781013607 @default.
• W2154233668 hasConcept C49453240 @default.
• W2154233668 hasConcept C64943373 @default.
• W2154233668 hasConcept C71924100 @default.
• W2154233668 hasConceptScore W2154233668C105702510 @default.
• W2154233668 hasConceptScore W2154233668C126322002 @default.
• W2154233668 hasConceptScore W2154233668C134018914 @default.
• W2154233668 hasConceptScore W2154233668C141071460 @default.
• W2154233668 hasConceptScore W2154233668C170493617 @default.
• W2154233668 hasConceptScore W2154233668C17991360 @default.
• W2154233668 hasConceptScore W2154233668C203014093 @default.
• W2154233668 hasConceptScore W2154233668C2775944032 @default.
• W2154233668 hasConceptScore W2154233668C2776914184 @default.
• W2154233668 hasConceptScore W2154233668C2777077863 @default.
• W2154233668 hasConceptScore W2154233668C2777575956 @default.
• W2154233668 hasConceptScore W2154233668C2778468042 @default.
• W2154233668 hasConceptScore W2154233668C2780550940 @default.
• W2154233668 hasConceptScore W2154233668C2781013607 @default.
• W2154233668 hasConceptScore W2154233668C49453240 @default.
• W2154233668 hasConceptScore W2154233668C64943373 @default.
• W2154233668 hasConceptScore W2154233668C71924100 @default.

• next