Matches in SemOpenAlex for { <https://semopenalex.org/work/W2154251805> ?p ?o ?g. }
- W2154251805 endingPage "744" @default.
- W2154251805 startingPage "733" @default.
- W2154251805 abstract "Gene transcription responds to stress and metabolic signals to optimize growth and survival. Histone H3 (H3) lysine 4 trimethylation (K4me3) facilitates state changes, but how levels are coordinated with the environment is unclear. Here, we show that isomerization of H3 at the alanine 15-proline 16 (A15-P16) peptide bond is influenced by lysine 14 (K14) and controls gene-specific K4me3 by balancing the actions of Jhd2, the K4me3 demethylase, and Spp1, a subunit of the Set1 K4 methyltransferase complex. Acetylation at K14 favors the A15-P16trans conformation and reduces K4me3. Environmental stress-induced genes are most sensitive to the changes at K14 influencing H3 tail conformation and K4me3. By contrast, ribosomal protein genes maintain K4me3, required for their repression during stress, independently of Spp1, K14, and P16. Thus, the plasticity in control of K4me3, via signaling to K14 and isomerization at P16, informs distinct gene regulatory mechanisms and processes involving K4me3." @default.
- W2154251805 created "2016-06-24" @default.
- W2154251805 creator A5020782067 @default.
- W2154251805 creator A5029579746 @default.
- W2154251805 creator A5045655401 @default.
- W2154251805 creator A5048360717 @default.
- W2154251805 creator A5055424418 @default.
- W2154251805 creator A5055731960 @default.
- W2154251805 creator A5061640661 @default.
- W2154251805 creator A5080697552 @default.
- W2154251805 creator A5086533913 @default.
- W2154251805 date "2014-09-01" @default.
- W2154251805 modified "2023-10-16" @default.
- W2154251805 title "Lysine Acetylation Controls Local Protein Conformation by Influencing Proline Isomerization" @default.
- W2154251805 cites W1968514469 @default.
- W2154251805 cites W1969322634 @default.
- W2154251805 cites W1971763423 @default.
- W2154251805 cites W1974016204 @default.
- W2154251805 cites W1977622464 @default.
- W2154251805 cites W1978211526 @default.
- W2154251805 cites W1979249520 @default.
- W2154251805 cites W1994059637 @default.
- W2154251805 cites W1995114961 @default.
- W2154251805 cites W2000430596 @default.
- W2154251805 cites W2001360952 @default.
- W2154251805 cites W2004327896 @default.
- W2154251805 cites W2006225938 @default.
- W2154251805 cites W2008892277 @default.
- W2154251805 cites W2012466702 @default.
- W2154251805 cites W2021207245 @default.
- W2154251805 cites W2021978386 @default.
- W2154251805 cites W2022936129 @default.
- W2154251805 cites W2025836692 @default.
- W2154251805 cites W2025917857 @default.
- W2154251805 cites W2035262366 @default.
- W2154251805 cites W2036158314 @default.
- W2154251805 cites W2036479240 @default.
- W2154251805 cites W2036799174 @default.
- W2154251805 cites W2037319721 @default.
- W2154251805 cites W2037623882 @default.
- W2154251805 cites W2040894413 @default.
- W2154251805 cites W2041165979 @default.
- W2154251805 cites W2042080470 @default.
- W2154251805 cites W2042960789 @default.
- W2154251805 cites W2048186818 @default.
- W2154251805 cites W2048670128 @default.
- W2154251805 cites W2054150044 @default.
- W2154251805 cites W2054672812 @default.
- W2154251805 cites W2059380466 @default.
- W2154251805 cites W2062371417 @default.
- W2154251805 cites W2067435429 @default.
- W2154251805 cites W2070959297 @default.
- W2154251805 cites W2072420595 @default.
- W2154251805 cites W2084062043 @default.
- W2154251805 cites W2088831308 @default.
- W2154251805 cites W2095124555 @default.
- W2154251805 cites W2098066769 @default.
- W2154251805 cites W2101461473 @default.
- W2154251805 cites W2103302926 @default.
- W2154251805 cites W2110643178 @default.
- W2154251805 cites W2111793840 @default.
- W2154251805 cites W2119597461 @default.
- W2154251805 cites W2121045792 @default.
- W2154251805 cites W2122609791 @default.
- W2154251805 cites W2124721555 @default.
- W2154251805 cites W2127890316 @default.
- W2154251805 cites W2130770262 @default.
- W2154251805 cites W2133465414 @default.
- W2154251805 cites W2135540197 @default.
- W2154251805 cites W2136779909 @default.
- W2154251805 cites W2137683543 @default.
- W2154251805 cites W2145115083 @default.
- W2154251805 cites W2148940587 @default.
- W2154251805 cites W2150451971 @default.
- W2154251805 cites W2154026351 @default.
- W2154251805 cites W2158217645 @default.
- W2154251805 cites W2161006357 @default.
- W2154251805 cites W2161711392 @default.
- W2154251805 cites W2163585426 @default.
- W2154251805 cites W2164372773 @default.
- W2154251805 cites W2166612340 @default.
- W2154251805 cites W2172257662 @default.
- W2154251805 cites W2172290898 @default.
- W2154251805 doi "https://doi.org/10.1016/j.molcel.2014.07.004" @default.
- W2154251805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157579" @default.
- W2154251805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25127513" @default.
- W2154251805 hasPublicationYear "2014" @default.
- W2154251805 type Work @default.
- W2154251805 sameAs 2154251805 @default.
- W2154251805 citedByCount "38" @default.
- W2154251805 countsByYear W21542518052015 @default.
- W2154251805 countsByYear W21542518052016 @default.
- W2154251805 countsByYear W21542518052017 @default.
- W2154251805 countsByYear W21542518052018 @default.
- W2154251805 countsByYear W21542518052019 @default.
- W2154251805 countsByYear W21542518052020 @default.
- W2154251805 countsByYear W21542518052021 @default.
- W2154251805 countsByYear W21542518052022 @default.